Výsledky vyhledávání - "Jesse C Crow"

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

Autor: Iftekhar A Showpnil, Julia Selich-Anderson, Cenny Taslim, Megann A Boone, Jesse C Crow, Emily R Theisen, Stephen L Lessnick

Publikováno v: Nucleic Acids Research. 50:9814-9837

Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or a highly related FET/ETS chimera. EWS/FLI dysregulates transcription to induce and maintain sarcomagenesis, but the mechanisms utilized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada230c4af9f84f8be7476f7086a69ac
https://doi.org/10.1093/nar/gkac747

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Identification of a Novel FUS/ETV4 Fusion and Comparative Analysis with Other Ewing Sarcoma Fusion Proteins

Autor: Cenny Taslim, Julia Selich-Anderson, Megann A. Boone, James Hamill, Peter Heppner, Mark Winstanley, Andrew C. Wood, Stephen L. Lessnick, Jesse C. Crow, Mike Watson

Publikováno v: Molecular Cancer Research. 19:1795-1801

Ewing sarcoma is a pediatric bone cancer defined by a chromosomal translocation fusing one of the FET family members to an ETS transcription factor. There have been seven reported chromosomal translocations, with the most recent reported over a decad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::218c047e9357dc35869da83051a6d08e
https://doi.org/10.1158/1541-7786.mcr-21-0354

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Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma

Autor: E. John Tokarsky, Jesse C. Crow, Lillian M. Guenther, John Sherman, Cenny Taslim, Gabriela Alexe, Kathleen I. Pishas, Galen Rask, Blake S. Justis, Ana Kasumova, Kimberly Stegmaier, Stephen L. Lessnick, Emily R. Theisen

Publikováno v: Molecular cancer research : MCR. 20(7)

Expression of the fusion oncoprotein EWS/FLI causes Ewing sarcoma, an aggressive pediatric tumor characterized by widespread epigenetic deregulation. These epigenetic changes are targeted by novel lysine-specific demethylase-1 (LSD1) inhibitors, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d5a5995d217e1886fa3ab5debdd6c0
https://pubmed.ncbi.nlm.nih.gov/35298000

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Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing Sarcoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35016619fcdd3688e3895a8185c06a43
https://doi.org/10.1101/2021.12.13.472459

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EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

Autor: Stephen L. Lessnick, Julia Selich-Anderson, Emily R. Theisen, Jesse C. Crow, Megann A. Boone, Iftekhar A. Showpnil, Cenny Taslim

Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or highly related fusions. EWS/FLI dysregulates transcription to induce and maintain sarcomagenesis, but the mechanisms utilized are not fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5520a1c08dea7b353aaaf1976938bc08
https://doi.org/10.1101/2021.09.30.462658

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Identification of a Novel

Autor: Megann A, Boone, Cenny, Taslim, Jesse C, Crow, Julia, Selich-Anderson, Mike, Watson, Peter, Heppner, James, Hamill, Andrew C, Wood, Stephen L, Lessnick, Mark, Winstanley

Publikováno v: Molecular cancer research : MCR. 19(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d55f7339afeddcbe5dc5db76df55ba7
https://pubmed.ncbi.nlm.nih.gov/34465585

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Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteins

Autor: Mike Watson, Peter Heppner, Julia Selich-Anderson, M. Winstanley, Jesse C. Crow, M. A. Boone, Stephen L. Lessnick, Cenny Taslim, Andrew C. Wood, James Hamill

Ewing sarcoma is an aggressive pediatric bone cancer defined by a chromosomal translocation fusing one of the FET family members to a member of the ETS transcription factor family. To date, there have been seven reported translocations, with the most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07bd0931a181e00a80fc60777287dcea
https://doi.org/10.1101/2021.05.07.21256326

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The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

Autor: Jesse C. Crow, Andrea K Byrum, Benjamin Sunkel, Stephen L. Lessnick, Cenny Taslim, Benjamin Z. Stanton, Emily R. Theisen, Meng Wang, Julia Selich-Anderson, Megann A. Boone, Iftekhar A. Showpnil

Publikováno v: Oncogene

Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence of a chromosomal translocation: t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the amino-terminal domain of EWS to the carboxyl-terminus of FLI. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219be5705f7050cd1ddba5625ccea223
https://pubmed.ncbi.nlm.nih.gov/34145397

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Abstract PO-041: Genome-wide CRISPR/Cas9 screen reveals mitochondrial gene mutation as a driver for drug resistance in Ewing sarcoma

Autor: Stephen L. Lessnick, Jesse C. Crow, Kimberly Stegmaier, Emily R. Theisen, Lillian M. Guenther, Jack P. Tokarsky

Publikováno v: Cancer Research. 80:PO-041

Ewing sarcoma is a pediatric bone cancer caused by a chromosomal translocation event that generates the pathognomonic fusion protein, EWS/FLI, which acts as aberrant transcription factor. EWS/FLI is responsible for activating and repressing important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1c5a0830ae847c5b76f22e45283249
https://doi.org/10.1158/1538-7445.epimetab20-po-041

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