Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jesse B. Hopkins"'
Autor:
Aline Sandouk, Zhen Xu, Sankar Baruah, Mikaela Tremblay, Jesse B. Hopkins, Srinivas Chakravarthy, Lokesh Gakhar, Nicholas J. Schnicker, Jon C. D. Houtman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution. GRB2 dimers are forme
Externí odkaz:
https://doaj.org/article/dfd8a538987e4db2abc48518bca57d01
Autor:
Erik W. Martin, Tyler S. Harmon, Jesse B. Hopkins, Srinivas Chakravarthy, J. Jeremías Incicco, Peter Schuck, Andrea Soranno, Tanja Mittag
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The nucleation mechanisms of biological protein phase separation are poorly understood. Here, the authors perform time-resolved SAXS experiments with the low-complexity domain (LCD) of hnRNPA1 and uncover multiple kinetic regimes on the micro- to mil
Externí odkaz:
https://doaj.org/article/3515d63866274f01b905879042d061a9
Publikováno v:
IUCrJ, Vol 4, Iss 6, Pp 785-794 (2017)
Serial synchrotron-based crystallography using intense microfocused X-ray beams, fast-framing detectors and protein microcrystals held at 300 K promises to expand the range of accessible structural targets and to increase overall structure-pipeline t
Externí odkaz:
https://doaj.org/article/7fd008b5404b415fb1120c06ad9ab168
Autor:
Katarina Koruza, A. Briana Murray, Brian P. Mahon, Jesse B. Hopkins, Wolfgang Knecht, Robert McKenna, S. Zoë Fisher
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5277 (2020)
Upregulation of carbonic anhydrase IX (CA IX) is associated with several aggressive forms of cancer and promotes metastasis. CA IX is normally constitutively expressed at low levels in selective tissues associated with the gastrointestinal tract, but
Externí odkaz:
https://doaj.org/article/2b4e2001d8d14e269861a6a11aa976e6
Publikováno v:
Nucleic Acids Research. 51:1943-1959
Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations have revealed that promoter G4s are transcriptional regulators. Little structural informat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d409dfd27b7ed4585cb38cf1dbb4cb8
https://doi.org/10.1093/nar/gkad014
https://doi.org/10.1093/nar/gkad014
Autor:
Christopher P. Ptak, Tabitha A. Peterson, Jesse B. Hopkins, Christopher A. Ahern, Michael E. Shy, Robert C. Piper
Mutations in Myelin Protein Zero (MPZ) account for 5% of Charcot-Marie-Tooth cases and can cause demyelinating or axonal phenotypes, reflecting the diverse roles of MPZ in Schwann cells. MPZ holds the apposing membranes of the myelin sheath together,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52ea1c55e4a10e4fdf90d568145b698
https://doi.org/10.1101/2023.03.18.533291
https://doi.org/10.1101/2023.03.18.533291
Publikováno v:
Biochemistry. 61:1091-1102
Endogenous circadian clocks control the rhythmicity of a broad range of behavioral and physiological processes, and this is entrained by the daily fluctuations in light and dark. Nocturnin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e66246a7a14aa0bf0835b941976c63
https://doi.org/10.1021/acs.biochem.2c00072
https://doi.org/10.1021/acs.biochem.2c00072
Autor:
Robert C Monsen, Lynn W DeLeeuw, William L Dean, Robert D Gray, Srinivas Chakravarthy, Jesse B Hopkins, Jonathan B Chaires, John O Trent
Publikováno v:
Nucleic Acids Research. 50:4127-4147
We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach. Our approach uses quantitative biophysical tools (analytical ultracentrifugation, small-angle X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0957c5403c4afa49626d2a0a8e1f49
https://doi.org/10.1093/nar/gkac182
https://doi.org/10.1093/nar/gkac182
Autor:
Ruchi Yadav, Valentine V. Courouble, Sanjay K. Dey, Jerry Joe E.K. Harrison, Jennifer Timm, Jesse B. Hopkins, Ryan L. Slack, Stefan G. Sarafianos, Francesc X. Ruiz, Patrick R. Griffin, Eddy Arnold
Publikováno v:
Science Advances. 8
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic. Its ∼30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121231faca27c1b4c12ed2c7d867f5bf
https://doi.org/10.1126/sciadv.add2191
https://doi.org/10.1126/sciadv.add2191
Autor:
Amanda L. Photenhauer, Filipe M. Cerqueira, Rosendo Villafuerte-Vega, Krista M. Armbruster, Filip Mareček, Tiantian Chen, Zdzislaw Wawrzak, Jesse B. Hopkins, Craig W. Vander Kooi, Štefan Janeček, Brandon T. Ruotolo, Nicole M. Koropatkin
Resistant starch is a prebiotic with breakdown by gut bacteria requiring the action of specialized amylases and starch-binding proteins. The human gut symbiontRuminococcus bromiiexpresses granular starch-binding protein Sas6 (Starch Adherence System
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffefc67d77ebb93ba4c31d31967c74bb
https://doi.org/10.1101/2022.11.20.514607
https://doi.org/10.1101/2022.11.20.514607