Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jesse B Hopkins"'
Autor:
Daniel A Keedy, Lillian R Kenner, Matthew Warkentin, Rahel A Woldeyes, Jesse B Hopkins, Michael C Thompson, Aaron S Brewster, Andrew H Van Benschoten, Elizabeth L Baxter, Monarin Uervirojnangkoorn, Scott E McPhillips, Jinhu Song, Roberto Alonso-Mori, James M Holton, William I Weis, Axel T Brunger, S Michael Soltis, Henrik Lemke, Ana Gonzalez, Nicholas K Sauter, Aina E Cohen, Henry van den Bedem, Robert E Thorne, James S Fraser
Publikováno v:
eLife, Vol 4 (2015)
Determining the interconverting conformations of dynamic proteins in atomic detail is a major challenge for structural biology. Conformational heterogeneity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to i
Externí odkaz:
https://doaj.org/article/20ede3c217614534b0cc830dee6b77a3
Autor:
Yevhenii Kyriukha, Maxwell B. Watkins, Jennifer M. Redington, Nithya Chintalapati, Abhishek Ganti, Reza Dastvan, Vladimir N. Uversky, Jesse B. Hopkins, Nicola Pozzi, Sergey Korolev
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111259- (2024)
Summary: The partner and localizer of BRCA2 (PALB2) is a scaffold protein linking BRCA1 with BRCA2 and RAD51 during homologous recombination (HR). PALB2 interaction with DNA strongly enhances HR in cells, while the PALB2 DNA-binding domain (PALB2-DBD
Externí odkaz:
https://doaj.org/article/c439c487940a4e6fa6c652461f0b310b
Autor:
Aline Sandouk, Zhen Xu, Sankar Baruah, Mikaela Tremblay, Jesse B. Hopkins, Srinivas Chakravarthy, Lokesh Gakhar, Nicholas J. Schnicker, Jon C. D. Houtman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution. GRB2 dimers are forme
Externí odkaz:
https://doaj.org/article/dfd8a538987e4db2abc48518bca57d01
Autor:
Erik W. Martin, Tyler S. Harmon, Jesse B. Hopkins, Srinivas Chakravarthy, J. Jeremías Incicco, Peter Schuck, Andrea Soranno, Tanja Mittag
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The nucleation mechanisms of biological protein phase separation are poorly understood. Here, the authors perform time-resolved SAXS experiments with the low-complexity domain (LCD) of hnRNPA1 and uncover multiple kinetic regimes on the micro- to mil
Externí odkaz:
https://doaj.org/article/3515d63866274f01b905879042d061a9
Publikováno v:
Nucleic Acids Research. 51:1943-1959
Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations have revealed that promoter G4s are transcriptional regulators. Little structural informat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d409dfd27b7ed4585cb38cf1dbb4cb8
https://doi.org/10.1093/nar/gkad014
https://doi.org/10.1093/nar/gkad014
Publikováno v:
IUCrJ, Vol 4, Iss 6, Pp 785-794 (2017)
Serial synchrotron-based crystallography using intense microfocused X-ray beams, fast-framing detectors and protein microcrystals held at 300 K promises to expand the range of accessible structural targets and to increase overall structure-pipeline t
Externí odkaz:
https://doaj.org/article/7fd008b5404b415fb1120c06ad9ab168
Autor:
Christopher P. Ptak, Tabitha A. Peterson, Jesse B. Hopkins, Christopher A. Ahern, Michael E. Shy, Robert C. Piper
Mutations in Myelin Protein Zero (MPZ) account for 5% of Charcot-Marie-Tooth cases and can cause demyelinating or axonal phenotypes, reflecting the diverse roles of MPZ in Schwann cells. MPZ holds the apposing membranes of the myelin sheath together,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52ea1c55e4a10e4fdf90d568145b698
https://doi.org/10.1101/2023.03.18.533291
https://doi.org/10.1101/2023.03.18.533291
Publikováno v:
Biochemistry. 61:1091-1102
Endogenous circadian clocks control the rhythmicity of a broad range of behavioral and physiological processes, and this is entrained by the daily fluctuations in light and dark. Nocturnin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e66246a7a14aa0bf0835b941976c63
https://doi.org/10.1021/acs.biochem.2c00072
https://doi.org/10.1021/acs.biochem.2c00072
Autor:
Robert C Monsen, Lynn W DeLeeuw, William L Dean, Robert D Gray, Srinivas Chakravarthy, Jesse B Hopkins, Jonathan B Chaires, John O Trent
Publikováno v:
Nucleic Acids Research. 50:4127-4147
We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach. Our approach uses quantitative biophysical tools (analytical ultracentrifugation, small-angle X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0957c5403c4afa49626d2a0a8e1f49
https://doi.org/10.1093/nar/gkac182
https://doi.org/10.1093/nar/gkac182
Autor:
Amanda L. Photenhauer, Filipe M. Cerqueira, Rosendo Villafuerte-Vega, Krista M. Armbruster, Filip Mareček, Tiantian Chen, Zdzislaw Wawrzak, Jesse B. Hopkins, Craig W. Vander Kooi, Štefan Janeček, Brandon T. Ruotolo, Nicole M. Koropatkin
Resistant starch is a prebiotic with breakdown by gut bacteria requiring the action of specialized amylases and starch-binding proteins. The human gut symbiontRuminococcus bromiiexpresses granular starch-binding protein Sas6 (Starch Adherence System
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffefc67d77ebb93ba4c31d31967c74bb
https://doi.org/10.1101/2022.11.20.514607
https://doi.org/10.1101/2022.11.20.514607