Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jesse A. Rudd-Schmidt"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing. The pore-forming perforin is essential for the function of cyt
Externí odkaz:
https://doaj.org/article/72534967b2074930a658cb5e8e398437
Autor:
Jesse A. Rudd-Schmidt, Adrian W. Hodel, Tahereh Noori, Jamie A. Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A. Trapani, Bart W. Hoogenboom, Ilia Voskoboinik
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Cytotoxic T lymphocytes (CTLs) eliminate virus-infected and cancerous cells by secreting the pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes). Here authors show that two mechanisms protect the membranes of CTLs from disr
Externí odkaz:
https://doaj.org/article/0b570a4b9b4f425cbf44500be5992740
Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1
Autor:
Daniela Castiblanco, Jesse A. Rudd-Schmidt, Tahereh Noori, Vivien R. Sutton, Ya Hui Hung, Thijs W. H. Flinsenberg, Adrian W. Hodel, Neil D. Young, Nicholas Smith, Drago Bratkovic, Heidi Peters, Mark Walterfang, Joseph A. Trapani, Amelia J. Brennan, Ilia Voskoboinik
Publikováno v:
Blood. 139:1833-1849
Niemann-Pick disease type C1 (NP-C1) is a rare lysosomal storage disorder resulting from mutations in an endolysosomal cholesterol transporter, NPC1. Despite typically presenting with pronounced neurological manifestations, NP-C1 also resembles long-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8076d8b71ec0bd955f1f4011ff0b06e0
https://doi.org/10.1182/blood.2021013477
https://doi.org/10.1182/blood.2021013477
Autor:
Tahereh Noori, Jesse Alexander Rudd-Schmidt, Alisa Kane, Katie Frith, Paul E Gray, Hannah Hu, Danny Hsu, Clara W.T. Chung, Adrian W Hodel, Joseph A. Trapani, Ilia Voskoboinik
Publikováno v:
Blood.
Familial forms of the severe immunoregulatory disease Haemophagocytic Lymphohistiocytosis (HLH) arise from bi-allelic mutations in the PRF1, UNC13D, STXBP2 and STX11 genes. Early and accurate diagnosis of the disease is important to determine the mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff4466ab662de8f1ef82bf2929ba73e3
https://doi.org/10.1182/blood.2022018398
https://doi.org/10.1182/blood.2022018398
Autor:
Ilia Voskoboinik, Adrian W. Hodel, Joseph A. Trapani, Bart W. Hoogenboom, Jesse A Rudd-Schmidt
Publikováno v:
Faraday Discussions
Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2807cad19539c5d033d4f3809c7d79e5
https://doi.org/10.1101/2020.04.22.054890
https://doi.org/10.1101/2020.04.22.054890
Publikováno v:
Methods in enzymology. 629
Perforin is an indispensable effector protein of primary cytotoxic lymphocytes (CTL or NK cells) that typically defend the host against virus infection, or gene-modified (chimeric antigen receptor-CAR) anticancer T cells. Perforin's pore-forming acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91829e1b85a53de1563683c21a16045d
https://pubmed.ncbi.nlm.nih.gov/31727246
https://pubmed.ncbi.nlm.nih.gov/31727246
Autor:
Jamie A. Lopez, Joseph A. Trapani, Adrian W. Hodel, Hyun-Jung Cho, Bart W. Hoogenboom, Tahereh Noori, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Jesse A Rudd-Schmidt
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTLs achieve this by forming an immunological synapse with their targets and secreting a pore-forming protein (perforin) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c236cee6f848eeaf0d44b437a5ddd01d
http://europepmc.org/articles/PMC6881447
http://europepmc.org/articles/PMC6881447
Perforin is an indispensable effector protein of primary cytotoxic lymphocytes (CTL or NK cells) that typically defend the host against virus infection, or gene-modified (chimeric antigen receptor-CAR) anticancer T cells. Perforin's pore-forming acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f86dc74e6959d21bdf872f12f22e94d
https://doi.org/10.1016/bs.mie.2019.07.034
https://doi.org/10.1016/bs.mie.2019.07.034
Autor:
Gersande Lena, Julie Ann Spicer, Dani Michelle Lyons, Annette Ciccone, Joseph A. Trapani, Kristiina M. Huttunen, Jesse A Rudd-Schmidt, Christian K. Miller, Jamie A. Lopez, Nuala A. Helsby, Kylie A. Browne, Stephen M. F. Jamieson, Matthew J. Bull, William A. Denny, Ilia Voskoboinik, Patrick D. O'Connor
Publikováno v:
Journal of Medicinal Chemistry
A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure-activity relationships were explored through variation of an isoindolinone or 3,4-dihydrois
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc0f4c079e4e6205976f06fb962e7b6
http://europepmc.org/articles/PMC3865801
http://europepmc.org/articles/PMC3865801
Autor:
Misty R, Jenkins, Jesse A, Rudd-Schmidt, Jamie A, Lopez, Kelly M, Ramsbottom, Stuart I, Mannering, Daniel M, Andrews, Ilia, Voskoboinik, Joseph A, Trapani
Publikováno v:
The Journal of Experimental Medicine
Jenkins et al. discover that failure of perforin and granzyme cytotoxicity by human and mouse CTLs/NK cells prolongs the immunological synapse, leading to repetitive calcium signaling and hypersecretion of inflammatory mediators that subsequently act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00cb87f255b821b37defc7f6aed3b7d