Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jesse A. May"'
Autor:
Jesse A. May, Najam A. Sharif
Publikováno v:
Expert Review of Ophthalmology. 6:105-120
Although several classes of drugs, including FP-receptor prostaglandin agonist analogs, are available to treat elevated intraocular pressure (IOP) associated with glaucoma, novel pharmaceuticals to treat this potentially blinding disease are still be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29aa5944244f7ba79762f5b29aa6d4c1
https://doi.org/10.1586/eop.10.69
https://doi.org/10.1586/eop.10.69
Autor:
Jesse A. May, Najam A. Sharif, Hwang-Hsing Chen, John C. Liao, Curtis R. Kelly, Richard A. Glennon, Richard Young, Jun-Xu Li, Kenner C. Rice, Charles P. France
Publikováno v:
Pharmacology Biochemistry and Behavior. 91:307-314
AL-38022A is a novel synthetic serotonergic (5-HT) ligand that exhibited high affinity for each of the 5-HT2 receptor subtypes (Ki ≤ 2.2 nM), but a significantly lower (>100-fold less) affinity for other 5-HT receptors. In addition, AL-38022A displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6141a94380080c4f073dc5f24b951f7
https://doi.org/10.1016/j.pbb.2008.07.015
https://doi.org/10.1016/j.pbb.2008.07.015
Autor:
Mark R. Hellberg, Bryon S. Severns, William F. Holt, Richard Young, Richard A. Glennon, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen, Curtis R. Kelly, Marsha A. McLaughlin, Jesse A. May
Publikováno v:
Journal of medicinal chemistry. 58(22)
Recently, it has been reported that 5-HT2 receptor agonists effectively reduce intraocular pressure (IOP) in a nonhuman primate model of glaucoma. Although 1-[(2S)-2-aminopropyl]indazol-6-ol (AL-34662) was shown to have good efficacy in this nonhuman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efded27acf90f8c38ea878165340de3
https://pubmed.ncbi.nlm.nih.gov/26551970
https://pubmed.ncbi.nlm.nih.gov/26551970
Autor:
Zixia Feng, Tom Brittain, Mark R. Hellberg, Grant Carr, Jesse A. May, Macarena Irigoyen, Damon Colbert, Shouxi Xu, Alfred N. Van Hoek, Peter M. Brown, Rajkumar V. Patil, Alok K. Mitra, Kulandaiappan Varadaraj, M. B. Wax, Andrew Rusinko, Najam A. Sharif, S. Sindhu Kumari
Publikováno v:
Chemical biologydrug design. 87(5)
Aquaporins (AQPs) are a family of membrane proteins that function as channels facilitating water transport in response to osmotic gradients. These play critical roles in several normal physiological and pathological states and are targets for drug di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca01fb7cf84bf488e1c14a50826c5a8e
https://pubmed.ncbi.nlm.nih.gov/26685080
https://pubmed.ncbi.nlm.nih.gov/26685080
Publikováno v:
Journal of Medicinal Chemistry. 49:318-328
Serotonin 5-HT(2) receptor agonists have been identified as a potential new class of agents for the treatment of ocular hypertension and glaucoma. The initially reported tryptamine analogues displayed either poor solution stability, potent central ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2a30a128ca45a4bfb792b4b15d972e
https://doi.org/10.1021/jm050663x
https://doi.org/10.1021/jm050663x
Autor:
Marsha A. McLaughlin, Andrew Rusinko, Vincent M. Lynch, Hwang-Hsing Chen, Jesse A. May, Najam A. Sharif
Publikováno v:
Journal of Medicinal Chemistry. 46:4188-4195
Serotonin 5-HT2 receptor agonists have recently been shown to be effective in lowering intraocular pressure in nonhuman primates and represent a potential new class of antiglaucoma agents. As part of an effort to identify new selective agonists at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9285e939bc004b5842090164c93655
https://doi.org/10.1021/jm030205t
https://doi.org/10.1021/jm030205t
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:301-309
Published investigations of serotonin-1A (5-hydroxytryptamine1A; 5-HT1A) receptor agonists and serotonin-2A (5-hydroxytryptamine2A; 5-HT2A) receptor antagonists in nonprimate species provide conflicting results with regard to their intraocular pressu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566796ff9d0a2440ed74560989adbd03
https://doi.org/10.1124/jpet.103.049528
https://doi.org/10.1124/jpet.103.049528
Autor:
Jesse A. May, Ernest U. Do, Robert Selliah, Judith Egan, Anura P. Dantanarayana, Karen S. Haggard
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:173-183
A method for the preparation of tritium labeled travoprost, a new ocular hypotensive prostaglandin, is described. A highly selective catalytic deiodination has been identified which provides [phenyl-2-3H]-travoprost in a single synthetic step from 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c5f30f659d3ea74e897ed207f4fa17
https://doi.org/10.1002/jlcr.441
https://doi.org/10.1002/jlcr.441
Autor:
Sharon Gross, William S. Sly, Hwang-Hsing Chen, Marsha A. McLaughlin, Jesse A. May, Thomas R. Dean, John B. Liao
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:957-975
Novel non-chiral 2H-thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides were synthesized for evaluation as potential candidates for the treatment of glaucoma. All of the compounds prepared were potent high affinity inhibitors of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177b596e158b58341704f907315d92f3
https://doi.org/10.1016/s0968-0896(00)00026-2
https://doi.org/10.1016/s0968-0896(00)00026-2
Publikováno v:
Journal of Heterocyclic Chemistry. 36:65-73
3-(Methoxymethoxymethyl)-2-thiophenesulfonamides and 3-hydroxymethyl-N-methoxymethyl-2-thiophenesulfonamides have been shown to undergo cyclization when treated under anhydrous acidic conditions to provide the novel 2,3-dihydro-5H-thieno[2,3-e]-4,1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694f21046da4d34ac66668d03d690ac9
https://doi.org/10.1002/jhet.5570360111
https://doi.org/10.1002/jhet.5570360111