Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jessamy Tiffen"'
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Epigenetic dysregulation has been implicated in a variety of pathological processes including carcinogenesis. A major group of enzymes that influence epigenetic modifications are lysine demethylases (KDMs) also known as “erasers” which remove met
Externí odkaz:
https://doaj.org/article/4b0da8029eaa444e8934b285734b80d3
Autor:
Aniruddha Chatterjee, Euan J. Rodger, Antonio Ahn, Peter A. Stockwell, Matthew Parry, Jyoti Motwani, Stuart J. Gallagher, Elena Shklovskaya, Jessamy Tiffen, Michael R. Eccles, Peter Hersey
Publikováno v:
iScience, Vol 4, Iss , Pp 312-325 (2018)
Summary: Constitutive expression of the immune checkpoint, PD-L1, inhibits anti-tumor immune responses in cancer, although the factors involved in PD-L1 regulation are poorly understood. Here we show that loss of global DNA methylation, particularly
Externí odkaz:
https://doaj.org/article/f57d918105734591bb6113f96ed367ba
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 2, Pp 121-132 (2016)
The epigenetic modifier EZH2 is in the center of a repressive complex controlling differentiation of normal cells. In cancer EZH2 has been implicated in silencing tumor suppressor genes. Its role in melanoma as well as target genes affected by EZH2 a
Externí odkaz:
https://doaj.org/article/704f39f89a894b89a4d5598140a5c899
Autor:
Kavitha Gowrishankar, Dilini Gunatilake, Stuart J Gallagher, Jessamy Tiffen, Helen Rizos, Peter Hersey
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123410 (2015)
Monoclonal antibodies against immune checkpoint blockade have proven to be a major success in the treatment of melanoma. The programmed death receptor-1 ligand-1 (PD-L1) expression on melanoma cells is believed to have an inhibitory effect on T cell
Externí odkaz:
https://doaj.org/article/32460bc623074c2c8229eced772a7c28
Autor:
Jeff Holst, John E.J. Rasko, Colleen C. Nelson, Grant Buchanan, Stephen C. Hendy, Melanie L. Lehman, Vineet Minhas, Annora Thoeng, Jessamy Tiffen, Cynthia Ng, Charles G. Bailey, Qian Wang
PDF file - 1.5K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5044669b4304c59017cd4d001a67230b
https://doi.org/10.1158/0008-5472.22389840
https://doi.org/10.1158/0008-5472.22389840
Autor:
Jeff Holst, John E.J. Rasko, Colleen C. Nelson, Grant Buchanan, Stephen C. Hendy, Melanie L. Lehman, Vineet Minhas, Annora Thoeng, Jessamy Tiffen, Cynthia Ng, Charles G. Bailey, Qian Wang
PDF file - 141K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cf862b2b58318cd0667adcb2bdfd18
https://doi.org/10.1158/0008-5472.22389837.v1
https://doi.org/10.1158/0008-5472.22389837.v1
Autor:
Jeff Holst, John E.J. Rasko, Colleen C. Nelson, Grant Buchanan, Stephen C. Hendy, Melanie L. Lehman, Vineet Minhas, Annora Thoeng, Jessamy Tiffen, Cynthia Ng, Charles G. Bailey, Qian Wang
l-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b389a969a7fe1b2d31aebe508a4d9f
https://doi.org/10.1158/0008-5472.c.6502737.v1
https://doi.org/10.1158/0008-5472.c.6502737.v1
Autor:
Peter Hersey, Stuart J. Cook, Helen M. McGuire, Mikaela C. Coleman, Carl G. Feng, Hsin-Yi Tseng, Jessamy Tiffen, Abdullah Al Emran, Stuart J. Gallagher
Publikováno v:
Pigment Cell & Melanoma Research
Melanoma, as for many other cancers, undergoes a selection process during progression that limits many innate and adaptive tumor control mechanisms. Immunotherapy with immune checkpoint blockade overcomes one of the escape mechanisms but if the tumor
Publikováno v:
British Journal of Cancer
Summary Major differences in survival of men and women from infectious diseases and cancers have been highlighted by death rates from COVID-19 infections. In cancer, attention has been focussed on differences in gene expression from X chromosomes in
Autor:
Stuart J. Gallagher, Hsin-Yi Tseng, Abdullah Al Emran, Jessamy Tiffen, Antonio Ahn, Helen Rizos, Farzana Ahmed, Michael R. Eccles, Sara Alavi, Dilini Gunatilake, Peter Hersey
The development of resistance to treatments of melanoma is commonly associated with upregulation of the MAPK pathway and development of an undifferentiated state. Prior studies have suggested that melanoma with these resistance characteristics may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d69504364d3baad7d54ade23bcc4119
https://doi.org/10.1101/2021.08.23.457344
https://doi.org/10.1101/2021.08.23.457344