1406-P: ZP8396, a Novel Amylin Analogue, Induces Weight Loss in DIO Rats with a Formulation Space at Physiological pH

Autor: JOLANTA SKARBALIENE, JOAKIM LUNDQVIST, JESPER VILLADSEN

Publikováno v: Diabetes. 71

ZP8396, currently in phase 1, is a long-acting, amylin analogue designed to improve solubility and stability and allow for co-formulation with other peptides at physiological pH. Here we present in-vivo efficacy and formulation design space of ZP8396

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3aacf10bce3abc1b6159a572dfd0512
https://doi.org/10.2337/db22-1406-p

Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A–E as Well as β2- epi-Azumamide E and β3-epi-Azumamide E

Autor: Pernille Harris, Helle Marie Stephansen, Christian A. Olsen, Alex Maolanon, Jesper Villadsen

Publikováno v: Villadsen, J, Stephansen, H M, Maolanon, A, Harris, P & Olsen, C A 2013, ' Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A–E as Well as β2-epi-Azumamide E and β3-epi-Azumamide E ', Open Journal of Medicinal Chemistry, vol. 56, no. 16, pp. 206512-6520 . https://doi.org/10.1021/jm4008449

Cyclic tetrapeptide and depsipeptide natural products have proven useful as biological probes and drug candidates due to their potent activities as histone deacetylase (HDAC) inhibitors. Here, we present the syntheses of a class of cyclic tetrapeptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e50e6d5f2277b7199f50bbbd4f9414
https://doi.org/10.1021/jm4008449

Perforated Ordered K0-Groups

Autor: Jesper Villadsen, George A. Elliott

Publikováno v: Canadian Journal of Mathematics. 52:1164-1191

A simple C*-algebra is constructed for which theMurray-von Neumann equivalence classes of projections, with the usual addition—induced by addition of orthogonal projections—form the additive semigroup{0, 2, 3, . . .}.(This is a particularly simpl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42cd845ac03237e8f884ed31fcfd212b
https://doi.org/10.4153/cjm-2000-049-9

The Range of the Elliott Invariant of the Simple AH-Algebras with Slow Dimension Growth

Autor: Jesper Villadsen

Publikováno v: K-Theory. 15:1-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4d2d4b310eb18aeddbd5b0ab1c85418
https://doi.org/10.1023/a:1007789028440

Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase

Autor: Maike Bublitz, Poul Nissen, Ditte F. Bonde, Ingrid Dach, Eleonora Tenori, Jesper V. Møller, Henriette Elisabeth Autzen, S. Brøgger Christensen, Pankaj Sehgal, Mette Alstrup Lie, Jesper Villadsen, Eleonora S. Paulsen, Claus Olesen, Birgit Schiøtt, Huizhen Liu

Publikováno v: Paulsen, E S, Villadsen, J, Tenori, E, Liu, H, Bonde, D F, Lie, M A, Bublitz, M, Olesen, C, Autzen, H E, Dach, I, Sehgal, P, Nissen, P, Møller, J V, Schiøtt, B & Christensen, SB 2013, ' Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase ', Journal of Medicinal Chemistry, vol. 56, no. 9, pp. 3609-3619 . https://doi.org/10.1021/jm4001083

A crystal structure suggests four water molecules are present in the binding cavity of thapsigargin in sarco/endoplasmic reticulum calcium ATPase (SERCA). Computational chemistry indicates that three of these water molecules mediate an extensive hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d802cab50068369f30d05bb5317065
https://pubmed.ncbi.nlm.nih.gov/23574308