Zobrazeno 1 - 10
of 490
pro vyhledávání: '"Jesper V Olsen"'
Autor:
Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W Mills, Kirstine Calloe, Ulrike Leurs, Johan Z Ye, Christian Stolte, Morten B Thomsen, Bo H Bentzen, Pia R Lundegaard, Morten S Olesen, Lars J Jensen, Jesper V Olsen, Alicia Lundby
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001144 (2021)
Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in card
Externí odkaz:
https://doaj.org/article/803278d7d2314c97a5198af5d5449f9c
Autor:
Beatrice Demarchi, Shaun Hall, Teresa Roncal-Herrero, Colin L Freeman, Jos Woolley, Molly K Crisp, Julie Wilson, Anna Fotakis, Roman Fischer, Benedikt M Kessler, Rosa Rakownikow Jersie-Christensen, Jesper V Olsen, James Haile, Jessica Thomas, Curtis W Marean, John Parkington, Samantha Presslee, Julia Lee-Thorp, Peter Ditchfield, Jacqueline F Hamilton, Martyn W Ward, Chunting Michelle Wang, Marvin D Shaw, Terry Harrison, Manuel Domínguez-Rodrigo, Ross DE MacPhee, Amandus Kwekason, Michaela Ecker, Liora Kolska Horwitz, Michael Chazan, Roland Kröger, Jane Thomas-Oates, John H Harding, Enrico Cappellini, Kirsty Penkman, Matthew J Collins
Publikováno v:
eLife, Vol 5 (2016)
Proteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving the protein sequence in ostrich (Struthionidae) eggshell, in
Externí odkaz:
https://doaj.org/article/a1ba7c012aeb465cb1b77e045d57372c
Autor:
Luise Ørsted Brandt, Anne Lisbeth Schmidt, Ulla Mannering, Mathilde Sarret, Christian D Kelstrup, Jesper V Olsen, Enrico Cappellini
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106875 (2014)
Denmark has an extraordinarily large and well-preserved collection of archaeological skin garments found in peat bogs, dated to approximately 920 BC - AD 775. These objects provide not only the possibility to study prehistoric skin costume and techno
Externí odkaz:
https://doaj.org/article/ad18a329643f42da8a4b720f4164b81a
Autor:
Rikke Bøgebo, Heiko Horn, Jesper V Olsen, Steen Gammeltoft, Lars J Jensen, Jakob L Hansen, Gitte L Christensen
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94672 (2014)
Recent progress in the understanding of seven-transmembrane receptor (7TMR) signalling has promoted the development of a new generation of pathway selective ligands. The angiotensin II type I receptor (AT1aR) is one of the most studied 7TMRs with res
Externí odkaz:
https://doaj.org/article/ec9ebed78472471cbad6359fc435aad3
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100692 (2014)
During mitosis large alterations in cellular structures occur rapidly, which to a large extent is regulated by post-translational modification of proteins. Modification of proteins with the small ubiquitin-related protein SUMO2/3 regulates mitotic pr
Externí odkaz:
https://doaj.org/article/4dfaa8b095bb4081a91ab08bd2458099
Autor:
Tien-chen Lin, Linda Gombos, Annett Neuner, Dominik Sebastian, Jesper V Olsen, Ajla Hrle, Christian Benda, Elmar Schiebel
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19700 (2011)
The yeast γ-tubulin Tub4 is assembled with Spc97 and Spc98 into the small Tub4 complex. The Tub4 complex binds via the receptor proteins Spc72 and Spc110 to the spindle pole body (SPB), the functional equivalent of the mammalian centrosome, where th
Externí odkaz:
https://doaj.org/article/45788b7e5f394afd92bd54afdcf3f7ca
Autor:
Gabriele Weintz, Jesper V Olsen, Katja Frühauf, Magdalena Niedzielska, Ido Amit, Jonathan Jantsch, Jörg Mages, Cornelie Frech, Lars Dölken, Matthias Mann, Roland Lang
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Recognition of microbial danger signals by toll‐like receptors (TLR) causes re‐programming of macrophages. To investigate kinase cascades triggered by the TLR4 ligand lipopolysaccharide (LPS) on systems level, we performed a global, quantitative
Externí odkaz:
https://doaj.org/article/9123c35ad0194ba89914b927fe5bd13e
Autor:
Fabrice Demeter, Clément Zanolli, Kira E. Westaway, Renaud Joannes-Boyau, Philippe Duringer, Mike W. Morley, Frido Welker, Patrick L. Rüther, Matthew M. Skinner, Hugh McColl, Charleen Gaunitz, Lasse Vinner, Tyler E. Dunn, Jesper V. Olsen, Martin Sikora, Jean-Luc Ponche, Eric Suzzoni, Sébastien Frangeul, Quentin Boesch, Pierre-Olivier Antoine, Lei Pan, Song Xing, Jian-Xin Zhao, Richard M. Bailey, Souliphane Boualaphane, Phonephanh Sichanthongtip, Daovee Sihanam, Elise Patole-Edoumba, Françoise Aubaile, Françoise Crozier, Nicolas Bourgon, Alexandra Zachwieja, Thonglith Luangkhoth, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Enrico Cappellini, Anne-Marie Bacon, Jean-Jacques Hublin, Eske Willerslev, Laura Shackelford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Evidence for the presence of Homo during the Middle Pleistocene is limited in continental Southeast Asia. Here, the authors report a hominin molar from Tam Ngu Hao 2 (Cobra Cave), dated to 164–131 kyr. They use morphological and paleoproteomic anal
Externí odkaz:
https://doaj.org/article/c3a70d6111914b0496d3d13ecbff674c
Autor:
Dimitra Papadopoulou, Fani Roumelioti, Christos Tzaferis, Panagiotis Chouvardas, Anna-Kathrine Pedersen, Filippos Charalampous, Eleni Christodoulou-Vafeiadou, Lydia Ntari, Niki Karagianni, Maria C. Denis, Jesper V. Olsen, Alexios N. Matralis, George Kollias
Publikováno v:
Papadopoulou, D, Roumelioti, F, Tzaferis, C, Chouvardas, P, Pedersen, A-K, Charalampous, F, Christodoulou-Vafeiadou, E, Ntari, L, Karagianni, N, Denis, M C, Olsen, J V, Matralis, A N & Kollias, G 2023, ' Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis ', JCI insight, vol. 8, no. 9, e165024 . https://doi.org/10.1172/jci.insight.165024
Synovial fibroblasts (SFs) are key pathogenic drivers in rheumatoid arthritis (RA). Their in vivo activation by TNF is sufficient to orchestrate full arthritic pathogenesis in animal models, and TNF blockade proved efficacious for a high percentage o
Autor:
Giulio Superti-Furga, Heinrich Kovar, Søren Brunak, Jesper V. Olsen, Keiryn L. Bennett, Jeffrey A. Toretsky, Cornelia Mutz, Kilian V. M. Huber, Theodore Papamarkou, Kristina B. Emdal, Kalliopi P. Tsafou, Branka Radic-Sarikas
Distribution of strong and very strong synergy across the three screens (appendix to Figure 1B and Figure 2A).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355ffe883e967b842d95e47785e1755a
https://doi.org/10.1158/1535-7163.22508544.v1
https://doi.org/10.1158/1535-7163.22508544.v1