Chronic corticosterone improves perseverative behavior in mice during sequential reversal learning

Autor: Anna U. Odland, Rune Sandahl, Jesper T. Andreasen

Publikováno v: Odland, A U, Sandahl, R & Andreasen, J T 2023, ' Chronic corticosterone improves perseverative behavior in mice during sequential reversal learning ', Behavioural Brain Research, vol. 450, 114479 . https://doi.org/10.1016/j.bbr.2023.114479

Background: Stressful life events can both trigger development of psychiatric disorders and promote positive behavioral changes in response to adversities. The relationship between stress and cognitive flexibility is complex, and conflicting effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faa1f753b0c574ab21eb31dbde3604b
https://curis.ku.dk/ws/files/348204695/1_s2.0_S0166432823001973_main.pdf

Sequential reversal learning: a new touchscreen schedule for assessing cognitive flexibility in mice

Autor: Jesper T. Andreasen, Rune Sandahl, Anna U. Odland

Publikováno v: Psychopharmacology. 238:383-397

The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d369b67f2657d85909ecc5ababb3ff
https://doi.org/10.1007/s00213-020-05687-6

Differential effects of chemogenetic inhibition of dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

Autor: David P.D. Woldbye, Amaia de Diego Ajenjo, Søren H. Christiansen, Annika H. Runegaard, Anders Petersen, Ulrik Gether, Søren H. Jørgensen, Ciarán M. Fitzpatrick, Andreas T. Sørensen, Jesper T. Andreasen, Julia C. McGirr, Nikolaj W. Hansen, Jean-François Perrier

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 90:264-276

Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder characterized by inattention, aberrant impulsivity, and hyperactivity. Although the underlying pathophysiology of ADHD remains unclear, dopamine and norepinephrine signaling or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8d5de9f449a0be076b6dc001930aeb
https://doi.org/10.1016/j.pnpbp.2018.12.004

Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

Autor: David P.D. Woldbye, Ciarán M. Fitzpatrick, Andreas T. Sørensen, Annika H. Runegaard, Jesper T. Andreasen, Ulrik Gether

Publikováno v: Pharmacological Reviews. 71:123-156

For more than 60 years, dopamine (DA) has been known as a critical modulatory neurotransmitter regulating locomotion, reward-based motivation, and endocrine functions. Disturbances in DA signaling have been linked to an array of different neurologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a9a922233629e5b8c60b5e9f153b05
https://doi.org/10.1124/pr.117.013995

Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

Autor: Günther H.J. Peters, Jesper T. Andreasen, François Crestey, Jesper L. Kristensen, Christian Soerensen, Anders A. Jensen, Charlotte Busk Magnus

Publikováno v: Crestey, F, Jensen, A A, Soerensen, C, Magnus, C B, Andreasen, J T, Peters, G H J & Kristensen, J L 2018, ' Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts ', Journal of Medicinal Chemistry, vol. 61, no. 4, pp. 1719-1729 . https://doi.org/10.1021/acs.jmedchem.7b01895

We describe the synthesis of tetrahydroisoquinolines and tetrahydroisoquinolinium salts together with their pharmacological properties at various nicotinic acetylcholine receptors. In general, the compounds were α4β2 nAChR antagonists, with the tet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba56890b2304cc381673594fbdcd22c2
https://doi.org/10.1021/acs.jmedchem.7b01895