Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jesper Sohlmer"'
Autor:
Jonathan Al-Saadi, Mathias Waldén, Mikael Sandell, Jesper Sohlmér, Rikard Grankvist, Ida Friberger, Agneta Andersson, Mattias Carlsten, Kenneth Chien, Johan Lundberg, Nevin Witman, Staffan Holmin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101225- (2024)
Heart failure has a poor prognosis and no curative treatment exists. Clinical trials are investigating gene- and cell-based therapies to improve cardiac function. The safe and efficient delivery of these therapies to solid organs is challenging. Here
Externí odkaz:
https://doaj.org/article/9aef628314494ff8911503063a61ba31
Autor:
Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f7261ffe7a7a4b8491b2ec59ef14a97b
Autor:
Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara, Kenneth R. Chien
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Abstract Background The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be clarified. Previous st
Externí odkaz:
https://doaj.org/article/01255acd28e041f6acfa35e58ea55910
Autor:
Jesper Sohlmer, Nevin Witman, William E. Louch, Eduarde Rohner, Erwin De Genst, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Molecular Medicine
Molecular Medicine
BackgroundThe human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be clarified. Previous studies have
Autor:
Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cardiogenic growth factors play important roles in heart development. Placental growth factor (PLGF) has previously been reported to have angiogenic effects; however, its potential role in cardiogenesis has not yet been determined. We analyz
Externí odkaz:
https://doaj.org/article/e6da8a6cf91241599f130c97c715953e
Autor:
Erwin De Genst, Kylie S. Foo, Yao Xiao, Eduarde Rohner, Emma de Vries, Jesper Sohlmér, Nevin Witman, Alejandro Hidalgo, Terje R. S. Kolstad, William E. Louch, Susanne Pehrsson, Andrew Park, Yasuhiro Ikeda, Xidan Li, Lorenz M. Mayr, Kate Wickson, Karin Jennbacken, Kenny Hansson, Regina Fritsche-Danielson, James Hunt, Kenneth R. Chien
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here the authors use modified RNA and VHH libraries to generate intrabodies that target dysregulated interactions between two calcium handling proteins in failing cardiomyocytes. Heart specific expression of the intrabodies in a murine heart failure
Externí odkaz:
https://doaj.org/article/41820d2e39ea4787978141037e15dc1e
Autor:
Chikai Zhou, Makoto Sahara, Jesper Sohlmer, Chuen Yan Leung, Kristine Bylund, Peter J. Gruber, Kenneth R. Chien, Nevin Witman, Federica Santoro, Mimmi M. Mononen
Publikováno v:
Developmental Cell
Summary The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian cardiogenesis; ho