Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Jesper Q Svejstrup"'
Autor:
Zita Fábián, Ellen S. Kakulidis, Ivo A. Hendriks, Ulrike Kühbacher, Nicolai B. Larsen, Marta Oliva-Santiago, Junhui Wang, Xueyuan Leng, A. Barbara Dirac-Svejstrup, Jesper Q. Svejstrup, Michael L. Nielsen, Keith Caldecott, Julien P. Duxin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also inv
Externí odkaz:
https://doaj.org/article/427734112e584ecc9b9b66e9b3111faa
Autor:
Andreas H Ehrensberger, Don-Marc Franchini, Philip East, Roger George, Nik Matthews, Sarah L Maslen, Jesper Q Svejstrup
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141250 (2015)
Externí odkaz:
https://doaj.org/article/abd65f3239a34b7ba3d560b3dea9b521
Autor:
Andreas H Ehrensberger, Don-Marc Franchini, Philip East, Roger George, Nik Matthews, Sarah L Maslen, Jesper Q Svejstrup
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133246 (2015)
A protocol is presented for the isolation of native mammalian chromatin as fibers of 25-250 nucleosomes under conditions that preserve the natural epigenetic signature. The material is composed almost exclusively of histones and DNA and conforms to t
Externí odkaz:
https://doaj.org/article/1fe78f08e85f4033a0d681f092a4dba2
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46398 (2012)
Ubiquitylation is a highly diverse and complex post-translational modification for the regulation of protein function and stability. Studies of ubiquitylation have, however, been hampered by its rapid reversal in cell extracts, for example through th
Externí odkaz:
https://doaj.org/article/ef2b02e7a3d541a8a69696b767bd88f0
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of STK19 (Serine Threon
Externí odkaz:
https://doaj.org/article/5875710c5aa34738909100f3eeb0c263
Autor:
Christian Bailly, Jean-Marc Barret, Nicolas Guilbaud, Charles Dumontet, Didier Cussac, Jean-Philippe Annereau, Jesper Q. Svejstrup, David J. Hobson, Sophie Bréand, Jérome Besse, Laurent Créancier, Luc DeVries, Stéphane Vispé
Supplementary Data from Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9663a2f107aece705dc218648dcf711d
https://doi.org/10.1158/1535-7163.22484879.v1
https://doi.org/10.1158/1535-7163.22484879.v1
Autor:
Christian Bailly, Jean-Marc Barret, Nicolas Guilbaud, Charles Dumontet, Didier Cussac, Jean-Philippe Annereau, Jesper Q. Svejstrup, David J. Hobson, Sophie Bréand, Jérome Besse, Laurent Créancier, Luc DeVries, Stéphane Vispé
Triptolide, a natural product extracted from the Chinese plant Tripterygium wilfordii, possesses antitumor properties. Despite numerous reports showing the proapoptotic capacity and the inhibition of NF-κB–mediated transcription by triptolide, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228be85587ab7332098bd38bdc32658e
https://doi.org/10.1158/1535-7163.c.6531635
https://doi.org/10.1158/1535-7163.c.6531635
Publikováno v:
Gregersen, L H, Mitter, R & Svejstrup, J Q 2022, ' Elongation factor-specific capture of RNA polymerase II complexes ', Cell Reports Methods, vol. 2, no. 12, 100368 . https://doi.org/10.1016/j.crmeth.2022.100368
Transcription of protein-coding genes is regulated by dynamic association of co-factors with RNA polymerase II (RNAPII). The function of these factors and their relationship with RNAPII is often poorly understood. Here, we present an approach for elo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d46a8a6bce2849ef1e50c853fdff21d
Autor:
Simona Cugusi, Prashanth Kumar Bajpe, Richard Mitter, Harshil Patel, Aengus Stewart, Jesper Q. Svejstrup
Publikováno v:
Cugusi, S, Bajpe, P K, Mitter, R, Patel, H, Stewart, A & Svejstrup, J Q 2022, ' An Important Role for RPRD1B in the Heat Shock Response ', Molecular and Cellular Biology, vol. 42, no. 10, pp. e0017322 . https://doi.org/10.1128/mcb.00173-22
During the heat shock response (HSR), heat shock factor (HSF1 in mammals) binds to target gene promoters, resulting in increased expression of heat shock proteins that help maintain protein homeostasis and ensure cell survival. Besides HSF1, only a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ce52d828cd08e10ba9754aaeabd2e4
https://doi.org/10.1128/mcb.00173-22
https://doi.org/10.1128/mcb.00173-22
Autor:
Wenzhi Gong, Richard Mitter, Wim Vermeulen, Dalton A Plummer, Chirantani Mukherjee, Marvin van Toorn, Karel Bezstarosti, Jesper Q. Svejstrup, Arjan F. Theil, Arnab Ray Chaudhuri, Anja Raams, Melanie van der Woude, John J. Wyrick, René Bernards, Yannick P Kok, Marcel A. T. M. van Vugt, Jurgen A. Marteijn, Barbara Steurer, Simona Cugusi, Adriaan B Houtsmuller, Jeroen Demmers, Shisheng Li, Joyce H.G. Lebbink, Kathiresan Selvam, Bart Geverts, Hannes Lans, Roel C. Janssens, Marit E. Geijer, Di Zhou, Bastiaan Evers, Calvin Shun Yu Lo
Publikováno v:
Nature Cell Biology, 23(6), 608-619. Nature Publishing Group
Nature cell biology
Nat Cell Biol
Nature cell biology
Nat Cell Biol
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8be2132ea5385e582a7d0be3b3d819
https://doi.org/10.1038/s41556-021-00692-z
https://doi.org/10.1038/s41556-021-00692-z