Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jesper Malmberg"'
Autor:
Roine I. Olsson, Rikard Pehrson, Rongfeng Chen, Jesper Malmberg, Anna Malmberg, Nafizal Hossain, Hanna Grindebacke, Mia Collins, Matti Lepistö, Yao Xiong, Nina Krutrök, Antonio Llinas, Thomas Hansson, Eva L. Hansson, Elisabeth Bäck, Anna Aagaard, Jane McPheat, Linda Thunberg, Sarah Lever, Agnes Leffler, Yafeng Xue, Stefan von Berg, Petter Svanberg, Frank Narjes, Marie Ramnegård, Glyn Hughes, Johan Jirholt
Publikováno v:
Journal of medicinal chemistry. 64(18)
Inverse agonists of the nuclear receptor RORC2 have been widely pursued as a potential treatment for a variety of autoimmune diseases. We have discovered a novel series of isoindoline-based inverse agonists of the nuclear receptor RORC2, derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5abd65b9c67744ef1cfe77ef55392ba
https://pubmed.ncbi.nlm.nih.gov/34464130
https://pubmed.ncbi.nlm.nih.gov/34464130
Autor:
Hanna Grindebacke, Frank Narjes, Eva L. Hansson, Yao Xiong, Antonio Llinas, Linda Thunberg, Jesper Malmberg, Stefan Tångefjord, Roine I. Olsson, Ge Hongbin, Rongfeng Chen, Yafeng Xue, Agnes Leffler, Hanna Leek, Thomas Hansson, Elisabeth Bäck, Jane McPheat, Nafizal Hossain, Matti Lepistö, Stefan von Berg, Johan Jirholt, Anna Aagaard
Publikováno v:
Journal of Medicinal Chemistry. 61:7796-7813
Retinoic acid receptor related orphan receptor γt (RORγt), has been identified as the master regulator of TH17-cell function and development, making it an attractive target for the treatment of autoimmune diseases by a small-molecule approach. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42539d4567cc086bb6e06886316ba550
https://doi.org/10.1021/acs.jmedchem.8b00783
https://doi.org/10.1021/acs.jmedchem.8b00783
Autor:
Dave Chapman, Victoria Ullah, Lisa Wissler, James Bird, Jesper Malmberg, Petter Svanberg, Christian Köhler, Antonios Nikitidis, Matti Lepistö, Stefan Geschwindner, Karl Edman, Tomas Drmota, Lena Ripa, Richard P. Harrison, Hui-Fang Chang, Goran Edenro, Tove Hegelund-Myrbäck, Ramon Hendrickx, Roine I. Olsson, Matthew Dearman, Philip Thorne, Antoni Llinas, Karolina Lawitz, Markus Berger
Publikováno v:
Journal of medicinal chemistry. 61(5)
Synthetic glucocorticoids (GC) are essential for the treatment of a broad range of inflammatory diseases. However, their use is limited by target related adverse effects on, e.g., glucose homeostasis and bone metabolism. Starting from a nonsteroidal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0a4a9fde9b3abea4540c722a20a060
https://pubmed.ncbi.nlm.nih.gov/29424542
https://pubmed.ncbi.nlm.nih.gov/29424542
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6659-6665
Two formally C-xylosylated analogs to 2-naphthyl beta-D-xylopyranoside, which is known to initiate priming of glucosaminoglycan chains, were synthesized by a position inversion of glucose (i.e., position 1 becomes position 5). The D-C-xyloside showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f9a981c3f645ded878444cfdb92f57
https://doi.org/10.1016/j.bmc.2006.05.068
https://doi.org/10.1016/j.bmc.2006.05.068
Autor:
Annika Åstrand, Anna Rönnborg, Emma Lindhardt, Ulrik Gran, Gert Strandlund, Hans Emtenäs, Zhong-Qing Yuan, Jonas Boström, Johan Sundell, Jonna Gyll, Ågot Högberg, Boel Löfberg, Tommy Iliefski, Roine I. Olsson, Birgit Andersson, Olle Hidestål, Tor Svensson, Ingemar Jacobson, Elin Forsström, Frida Persson, Christina Olsson, Annika Björe, Gunilla Linhardt, Öjvind Davidsson, Ola Fjellström, Jesper Malmberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(5)
A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure–activity relationships from lead structure C to optimized structure 3y are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71012effbd3cf129aff4e8df9e21b478
https://pubmed.ncbi.nlm.nih.gov/24513046
https://pubmed.ncbi.nlm.nih.gov/24513046
Publikováno v:
Carbohydrate research. 341(10)
Carbohydrates carrying an aromatic aglycon are important natural products and thus key synthetic targets. However, due to the electron-withdrawing properties of aromatic rings, phenols are difficult to glycosylate. This review covers the most common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bc73480fac0e8f1c04aa2fc8a3d9a6
https://pubmed.ncbi.nlm.nih.gov/16650391
https://pubmed.ncbi.nlm.nih.gov/16650391