Immunomodulation with IL-7 and IL-15 in HIV-1 infection

Autor: Jesper D. Gunst, Nilu Goonetilleke, Thomas A. Rasmussen, Ole S. Søgaard

Publikováno v: Journal of Virus Eradication, Vol 9, Iss 3, Pp 100347- (2023)

Immunomodulating agents are substances that modify the host immune responses in diseases such as infections, autoimmune conditions and cancers. Immunomodulators can be divided into two main groups: 1) immunostimulators that activate the immune system

Externí odkaz: https://doaj.org/article/af0b63c324924902a4aae5296409d05f

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity

Autor: Miriam Rosás-Umbert, Jesper D. Gunst, Marie H. Pahus, Rikke Olesen, Mariane Schleimann, Paul W. Denton, Victor Ramos, Adam Ward, Natalie N. Kinloch, Dennis C. Copertino, Tuixent Escribà, Anuska Llano, Zabrina L. Brumme, R. Brad Jones, Beatriz Mothe, Christian Brander, Julie Fox, Michel C. Nussenzweig, Sarah Fidler, Marina Caskey, Martin Tolstrup, Ole S. Søgaard

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Broadly neutralising anti-HIV-1 antibody (bNAb) administration in nonhuman primates has been shown to stimulate adaptive T cell-specific immunity, with infection prevention observed. In this work, the authors longitudinally analyse HIV-1 specific cel

Externí odkaz: https://doaj.org/article/ef639b4a891643dcb296cca780fd13c0

Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.

Autor: Jesper D. Gunst, Nina B. Staerke, Marie H. Pahus, Lena H. Kristensen, Jacob Bodilsen, Nicolai Lohse, Lars S. Dalgaard, Dorthe Brønnum, Ole Fröbert, Bo Hønge, Isik S. Johansen, Ida Monrad, Christian Erikstrup, Regitze Rosendal, Emil Vilstrup, Theis Mariager, Dorthe G. Bove, Rasmus Offersen, Shakil Shakar, Sara Cajander, Nis P. Jørgensen, Sajitha S. Sritharan, Peter Breining, Søren Jespersen, Klaus L. Mortensen, Mads L. Jensen, Lilian Kolte, Giacomo S. Frattari, Carsten S. Larsen, Merete Storgaard, Lars P. Nielsen, Martin Tolstrup, Eva A. Sædder, Lars J. Østergaard, Hien T.T. Ngo, Morten H. Jensen, Jesper F. Højen, Mads Kjolby, Ole S. Søgaard

Publikováno v: EClinicalMedicine, Vol 35, Iss , Pp 100849- (2021)

Background: The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Co

Externí odkaz: https://doaj.org/article/c25557f47802410fa852f84ca0e3b0e0

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

Autor: Jesper D. Gunst, Marie H. Pahus, Miriam Rosás-Umbert, I-Na Lu, Thomas Benfield, Henrik Nielsen, Isik S. Johansen, Rajesh Mohey, Lars Østergaard, Vibeke Klastrup, Maryam Khan, Mariane H. Schleimann, Rikke Olesen, Henrik Støvring, Paul W. Denton, Natalie N. Kinloch, Dennis C. Copertino, Adam R. Ward, Winiffer D. Conce Alberto, Silke D. Nielsen, Maria C. Puertas, Victor Ramos, Jacqueline D. Reeves, Christos J. Petropoulos, Javier Martinez-Picado, Zabrina L. Brumme, R. Brad Jones, Julie Fox, Martin Tolstrup, Michel C. Nussenzweig, Marina Caskey, Sarah Fidler, Ole S. Søgaard

Publikováno v: Gunst, J D, Pahus, M H, Rosás-Umbert, M, Lu, I-N, Benfield, T, Nielsen, H, Johansen, I S, Mohey, R, Østergaard, L, Klastrup, V, Khan, M, Schleimann, M H, Olesen, R, Støvring, H, Denton, P W, Kinloch, N N, Copertino, D C, Ward, A R, Alberto, W D C, Nielsen, S D, Puertas, M C, Ramos, V, Reeves, J D, Petropoulos, C J, Martinez-Picado, J, Brumme, Z L, Jones, R B, Fox, J, Tolstrup, M, Nussenzweig, M C, Caskey, M, Fidler, S & Søgaard, O S 2022, ' Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1 : a phase 1b/2a, randomized trial ', Nature Medicine, vol. 28, no. 11, pp. 2424-2435 . https://doi.org/10.1038/s41591-022-02023-7
Gunst, J D, Pahus, M H, Rosás-Umbert, M, Lu, I-N, Benfield, T, Nielsen, H, Johansen, I S, Mohey, R, Østergaard, L, Klastrup, V, Khan, M, Schleimann, M H, Olesen, R, Støvring, H, Denton, P W, Kinloch, N N, Copertino, D C, Ward, A R, Alberto, W D C, Nielsen, S D, Puertas, M C, Ramos, V, Reeves, J D, Petropoulos, C J, Martinez-Picado, J, Brumme, Z L, Jones, R B, Fox, J, Tolstrup, M, Nussenzweig, M C, Caskey, M, Fidler, S & Søgaard, O S 2022, ' Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1 : a phase 1b/2a, randomized trial ', Nature Medicine . https://doi.org/10.1038/s41591-022-02023-7
Gunst, J D, Pahus, M H, Rosás-Umbert, M, Lu, I N, Benfield, T, Nielsen, H, Johansen, I S, Mohey, R, Østergaard, L, Klastrup, V, Khan, M, Schleimann, M H, Olesen, R, Støvring, H, Denton, P W, Kinloch, N N, Copertino, D C, Ward, A R, Alberto, W D C, Nielsen, S D, Puertas, M C, Ramos, V, Reeves, J D, Petropoulos, C J, Martinez-Picado, J, Brumme, Z L, Jones, R B, Fox, J, Tolstrup, M, Nussenzweig, M C, Caskey, M, Fidler, S & Søgaard, O S 2022, ' Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1 : a phase 1b/2a, randomized trial ', Nature Medicine, vol. 28, no. 11, pp. 2424-2435 . https://doi.org/10.1038/s41591-022-02023-7

Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this phase 1b/2a, open-label, randomized controlled trial using a four-grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134238a307c4936cfa0d89c5fd761241
https://pubmed.ncbi.nlm.nih.gov/36253609

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection

Autor: Renée M van der Sluis, Lamin B Cham, Albert Gris‐Oliver, Kristine R Gammelgaard, Jesper G Pedersen, Manja Idorn, Ulvi Ahmadov, Sabina Sanches Hernandez, Ena Cémalovic, Stine H Godsk, Jacob Thyrsted, Jesper D Gunst, Silke D Nielsen, Janni J Jørgensen, Tobias Wang Bjerg, Anders Laustsen, Line S Reinert, David Olagnier, Rasmus O Bak, Mads Kjolby, Christian K Holm, Martin Tolstrup, Søren R Paludan, Lasse S Kristensen, Ole S Søgaard, Martin R Jakobsen

Publikováno v: van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Sanches Hernandez, S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Wang Bjerg, T, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', The EMBO Journal, pp. e109622 . https://doi.org/10.15252/embj.2021109622
van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Hernandez, S S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Bjerg, T W, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', EMBO Journal, vol. 41, no. 10, e109622 . https://doi.org/10.15252/embj.2021109622

Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infection is critical for developing treatments for severe COVID-19. Here, we find decreasing number of circulating plasmacytoid dendritic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fd30736af2a491a85fdee063fc4b93
https://doi.org/10.15252/embj.2021109622