Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jesper Bergwik"'
Autor:
Jesper Bergwik, Jielu Liu, Médea Padra, Ravi K. V. Bhongir, Lloyd Tanner, Yujiao Xiang, Mia Lundblad, Arne Egesten, Mikael Adner
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad ran
Externí odkaz:
https://doaj.org/article/dd0575e4dc414befa4090bcfd48ccd10
Autor:
Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects. Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), re
Externí odkaz:
https://doaj.org/article/340dac68eeb842cba993be2b6019607c
Autor:
Lloyd Tanner, Jesper Bergwik, Ravi K. V. Bhongir, Manoj Puthia, Pernilla Lång, Mohamad N. Ali, Charlotte Welinder, Patrik Önnerfjord, Jonas S. Erjefält, Lena Palmberg, Göran Andersson, Arne Egesten
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionDuring airway infection, upregulation of proinflammatory cytokines and subsequent immune cell recruitment is essential to mitigate bacterial infection. Conversely, during prolonged and non-resolving airway inflammation, neutrophils contri
Externí odkaz:
https://doaj.org/article/2ee8d6efa52445b69b6dfca1ea9deb16
Autor:
Lloyd Tanner, Jesper Bergwik, Ravi K. V. Bhongir, Lang Pan, Caijuan Dong, Olov Wallner, Christina Kalderén, Thomas Helleday, Istvan Boldogh, Mikael Adner, Arne Egesten
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background and aim: Allergic asthma is a complex inflammatory disease involving type 2 innate lymphoid cells, type 2 T helper cells, macrophages, and eosinophils. The disease is characterized by wheezing, dyspnea, coughing, chest tightness and variab
Externí odkaz:
https://doaj.org/article/f6fed02054d74206a115008f6a48c7fb
Autor:
Lloyd Tanner, Jesper Bergwik, Andrew B. Single, Ravi K. V. Bhongir, Jonas S. Erjefält, Arne Egesten
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background and aim: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, with most patients succumbing rapidly after diagnosis. The mevalonate pathway, which is involved in the regulation of c
Externí odkaz:
https://doaj.org/article/7030ce1199044af699e4c22048a05f5e
Autor:
Jesper Bergwik, Amanda Kristiansson, Jörgen Larsson, Simon Ekström, Bo Åkerström, Maria Allhorn
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101892- (2021)
Heparin and heparan sulfate (HS) are linear sulfated disaccharide polymers. Heparin is found mainly in mast cells, while heparan sulfate is found in connective tissue, extracellular matrix and on cell membranes in most tissues. α1-microglobulin (A1M
Externí odkaz:
https://doaj.org/article/bdf66cc8953d49eeb51cb9f28ad7f8a8
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
α1-microglobulin (A1M) is found in all vertebrates including humans. A1M was, together with retinol-binding protein and β-lactoglobulin, one of the three original lipocalins when the family first was proposed in 1985. A1M is described as an antioxi
Externí odkaz:
https://doaj.org/article/79878b2c08b74ca48e19a70a0e17d5d1
Autor:
Magnus L. R. Carlsson, Amanda Kristiansson, Jesper Bergwik, Selvaraju Kanagarajan, Leif Bülow, Bo Åkerström, Li-Hua Zhu
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
α1-Microglobulin (A1M) is a small glycoprotein that belongs to the lipocalin protein family. A major biological role of A1M is to protect cells and tissues against oxidative damage by clearing free heme and reactive oxygen species. Because of this,
Externí odkaz:
https://doaj.org/article/c03f7cc48cea44be9c5f237004875cbb
Autor:
Jesper Bergwik, Bo Åkerström
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Riboflavin (vitamin B2) is an important constituent of the prosthetic groups flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), which are utilized as electron-carriers in energy metabolism. Excitation by UV-light leads to the generati
Externí odkaz:
https://doaj.org/article/534b1a896ea849f2be9fdf71efe49077
Autor:
Lang Pan, Wenjing Hao, Yaoyao Xue, Ke Wang, Xu Zheng, Jixian Luo, Xueqing Ba, Yang Xiang, Xiaoqun Qin, Jesper Bergwik, Lloyd Tanner, Arne Egesten, Allan R Brasier, Istvan Boldogh
Publikováno v:
Nucleic Acids Research. 51:1087-1102
Reactive oxygen species (ROS) are implicated in epithelial cell-state transition and deposition of extracellular matrix upon airway injury. Of the many cellular targets of ROS, oxidative DNA modification is a major driving signal. However, the role o