Zobrazeno 1 - 10
of 813
pro vyhledávání: '"Jesper A. Olsen"'
Autor:
Tanveer Singh Batth, Marie Locard-Paulet, Nadezhda T. Doncheva, Blanca Lopez Mendez, Lars Juhl Jensen, Jesper Velgaard Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Proteins are the primary targets of almost all small molecule drugs. However, even the most selectively designed drugs can potentially target several unknown proteins. Identification of potential drug targets can facilitate design of new dru
Externí odkaz:
https://doaj.org/article/596874fe32fc4c529293f9473a9ae2e0
Autor:
Jiangbo Song, Zhiquan Li, Lei Zhou, Xin Chen, Wei Qi Guinevere Sew, Héctor Herranz, Zilu Ye, Jesper Velgaard Olsen, Yuan Li, Marianne Nygaard, Kaare Christensen, Xiaoling Tong, Vilhelm A. Bohr, Lene Juel Rasmussen, Fangyin Dai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract FOXO transcription factors modulate aging-related pathways and influence longevity in multiple species, but the transcriptional targets that mediate these effects remain largely unknown. Here, we identify an evolutionarily conserved FOXO tar
Externí odkaz:
https://doaj.org/article/6d8e7769443a4b1ca5a7abe0242df507
Autor:
Marta Rojas-Torres, Lucía Beltrán-Camacho, Ana Martínez-Val, Ismael Sánchez-Gomar, Sara Eslava-Alcón, Antonio Rosal-Vela, Margarita Jiménez-Palomares, Esther Doiz-Artázcoz, Mario Martínez-Torija, Rafael Moreno-Luna, Jesper V. Olsen, Ma. Carmen Duran-Ruiz
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-20 (2024)
Abstract Background Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by atherosclerosis. CLTI patients suffer from high risk of amputation of the lower extremities and e
Externí odkaz:
https://doaj.org/article/27bcbf1ec51e4b22868a84f0473da65b
Autor:
Akihiro Eguchi, Jesper V. Olsen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Receptor tyrosine kinases (RTKs) initiate cellular signaling pathways, which are regulated through a delicate balance of phosphorylation and dephosphorylation events. While many studies of RTKs have focused on downstream-activated kinases ca
Externí odkaz:
https://doaj.org/article/947e868b011645679c87cdc47b71da62
Autor:
Zilu Ye, Pierre Sabatier, Javier Martin-Gonzalez, Akihiro Eguchi, Maico Lechner, Ole Østergaard, Jingsheng Xie, Yuan Guo, Lesley Schultz, Rafaela Truffer, Dorte B. Bekker-Jensen, Nicolai Bache, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Mass spectrometry (MS)-based proteomics workflows typically involve complex, multi-step processes, presenting challenges with sample losses, reproducibility, requiring substantial time and financial investments, and specialized skills. Here
Externí odkaz:
https://doaj.org/article/5e6153097b5242d18061e20f48ee5094
Autor:
Baker Nawfal Jawad, Shakir Maytham Shaker, Izzet Altintas, Jesper Eugen-Olsen, Jan O. Nehlin, Ove Andersen, Thomas Kallemose
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Several scores predicting mortality at the emergency department have been developed. However, all with shortcomings either simple and applicable in a clinical setting, with poor performance, or advanced, with high performance, but clinically
Externí odkaz:
https://doaj.org/article/31932ed9474843cba7dc77a218e6dba5
Autor:
Christian Mirian, Maria Thastrup, René Mathiasen, Kjeld Schmiegelow, Jesper Velgaard Olsen, Ole Østergaard
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background The cerebrospinal fluid (CSF) proteome could offer important insights into central nervous system (CNS) malignancies. To advance proteomic research in pediatric CNS cancer, the current study aims to (1) evaluate past mass spectrom
Externí odkaz:
https://doaj.org/article/c280e0601b894603971f7bafe8a5060a
Autor:
Harry Warner, Giulia Franciosa, Guus van der Borg, Britt Coenen, Felix Faas, Claire Koenig, Rinse de Boer, René Classens, Sjors Maassen, Maksim V. Baranov, Shweta Mahajan, Deepti Dabral, Frans Bianchi, Niek van Hilten, Herre Jelger Risselada, Wouter H. Roos, Jesper Velgaard Olsen, Laia Querol Cano, Geert van den Bogaart
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113866- (2024)
Summary: To mount an adaptive immune response, dendritic cells must migrate to lymph nodes to present antigens to T cells. Critical to 3D migration is the nucleus, which is the size-limiting barrier for migration through the extracellular matrix. Her
Externí odkaz:
https://doaj.org/article/9c2fb1e58e4947c0a6fa89aaeb80c8a8
Autor:
Dorothea Mylopotamitaki, Florian S. Harking, Alberto J. Taurozzi, Zandra Fagernäs, Ricardo M. Godinho, Geoff M. Smith, Marcel Weiss, Tim Schüler, Shannon P. McPherron, Harald Meller, João Cascalheira, Nuno Bicho, Jesper V. Olsen, Jean-Jacques Hublin, Frido Welker
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract High-throughput proteomic analysis of archaeological skeletal remains provides information about past fauna community compositions and species dispersals in time and space. Archaeological skeletal remains are a finite resource, however, and
Externí odkaz:
https://doaj.org/article/d919b8ab4cc24ad19cf250f64f526ec5
Autor:
Shane C. Wright, Aikaterini Motso, Stefania Koutsilieri, Christian M. Beusch, Pierre Sabatier, Alessandro Berghella, Élodie Blondel-Tepaz, Kimberley Mangenot, Ioannis Pittarokoilis, Despoina-Christina Sismanoglou, Christian Le Gouill, Jesper V. Olsen, Roman A. Zubarev, Nevin A. Lambert, Alexander S. Hauser, Michel Bouvier, Volker M. Lauschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating therapeutic signaling from signaling associated with adverse events is an important step tow
Externí odkaz:
https://doaj.org/article/87f6a5fc98af40a19909134b0c703db6