Zobrazeno 1 - 10
of 873
pro vyhledávání: '"Jesper Wengel"'
Autor:
Jörg Duschmalé, Adrian Schäublin, Erik Funder, Steffen Schmidt, Łukasz J. Kiełpiński, Helle Nymark, Klaus Jensen, Troels Koch, Martina Duschmalé, Erich Koller, Marianne Ravn Møller, Simone Schadt, Christophe Husser, Andreas Brink, Sabine Sewing, Tanja Minz, Jesper Wengel, Konrad Bleicher, Meiling Li
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 176-188 (2022)
The introduction of sulfur into the phosphate linkage of chemically synthesized oligonucleotides creates the stereocenters on phosphorus atoms. Researchers have valued the nature of backbone stereochemistry and early on investigated drug properties f
Externí odkaz:
https://doaj.org/article/129e910e0f0444d193c51f62a0777c79
Autor:
Shankar Pandey, Shankar Mandal, Mathias Bogetoft Danielsen, Asha Brown, Changpeng Hu, Niels Johan Christensen, Alina Vitaliyivna Kulakova, Shixi Song, Tom Brown, Knud J. Jensen, Jesper Wengel, Chenguang Lou, Hanbin Mao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Chiral communication can propagate in secondary structures within the effective intermolecular force (IMF) range but it is not known whether long-range chiral communication exists between tertiary peptide structures. Here, the authors use single-mole
Externí odkaz:
https://doaj.org/article/1005fa8d3f614a3ba35af08e33c5fc2c
Autor:
Andreia S. Azevedo, Ricardo M. Fernandes, Ana R. Faria, Oscar F. Silvestre, Jana B. Nieder, Chenguang Lou, Jesper Wengel, Carina Almeida, Nuno F. Azevedo
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The application of nucleic acid mimics (NAMs), such as locked nucleic acid (LNA) and 2′-O-methyl-RNA (2’OMe), has improved the performance of fluorescence in situ hybridization (FISH) methods for the detection/location of clinical pathogens since
Externí odkaz:
https://doaj.org/article/827cea36aa284bb8a0f4066db87a9502
Autor:
Mathias B. Danielsen, Jesper Wengel
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1828-1848 (2021)
Antisense oligonucleotides (ASOs) have the ability of binding to endogenous nucleic acid targets, thereby inhibiting the gene expression. Although ASOs have great potential in the treatment of many diseases, the search for favorable toxicity profiles
Externí odkaz:
https://doaj.org/article/1b7504243dad401e8ba68390a09d57d8
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 994-1003 (2020)
Aptamers are short single-stranded oligonucleotides selected to bind with high affinity and specificity to a target. In contrast to antibodies, aptamers can be produced in large-scale in vitro systems without the need for any biological agents, makin
Externí odkaz:
https://doaj.org/article/6253146669254895867229e98a850e5d
Autor:
Anet Laanesoo, Egon Urgard, Kapilraj Periyasamy, Martti Laan, Yury A. Bochkov, Alar Aab, Nathaniel Magilnick, Margus Pooga, James E. Gern, Sebastian L. Johnston, Jonathan M. Coquet, Mark P. Boldin, Jesper Wengel, Alan Altraja, Grazyna Bochenek, Bogdan Jakiela, Ana Rebane
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Abstract Rhinovirus (RV) infections are associated with asthma exacerbations. MicroRNA‐146a and microRNA‐146b (miR‐146a/b) are anti‐inflammatory miRNAs that suppress signaling through the nuclear factor kappa B (NF‐κB) pathway and inhibit
Externí odkaz:
https://doaj.org/article/2f02d187dc6f47c59c371c23de0107ac
Autor:
Pedro M.D. Moreno, Ana R. Ferreira, Daniela Salvador, Maria T. Rodrigues, Marília Torrado, Eva D. Carvalho, Ulf Tedebark, Mónica M. Sousa, Isabel F. Amaral, Jesper Wengel, Ana P. Pêgo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 393-406 (2018)
After spinal cord injury (SCI), nerve regeneration is severely hampered due to the establishment of a highly inhibitory microenvironment at the injury site, through the contribution of multiple factors. The potential of antisense oligonucleotides (AO
Externí odkaz:
https://doaj.org/article/b4a65d46d57a47d3873ab1bc90af99e7
Autor:
Weronika Kotkowiak, Jolanta Lisowiec-Wachnicka, Jakub Grynda, Ryszard Kierzek, Jesper Wengel, Anna Pasternak
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 304-316 (2018)
Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA o
Externí odkaz:
https://doaj.org/article/4fb784a3730b4c62b82c7cf5dcfb64e8
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 66 (2021)
Oligonucleotides with the sequences 5′-GTG AUPA TGC, 5′-GCA TAUP CAC and 5′-GUPG ATA UPGC, where UP is 2′-O-propargyl uridine, were subjected to post-synthetic Cu(I)-catalyzed azide–alkyne cycloaddition to attach 1,4,7,10-tetraazacyclododec
Externí odkaz:
https://doaj.org/article/34036697d7ef4c3aa0cc0d33123225df
Autor:
Michaella Georgiadou, Melina Christou, Kleitos Sokratous, Jesper Wengel, Kyriaki Michailidou, Kyriacos Kyriacou, Andrie Koutsoulidou, Nikolaos P. Mastroyiannopoulos, Leonidas A. Phylactou
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1113 (2021)
Duchenne muscular dystrophy (DMD) is a fatal disorder characterised by progressive muscle wasting. It is caused by mutations in the dystrophin gene, which disrupt the open reading frame leading to the loss of functional dystrophin protein in muscle f
Externí odkaz:
https://doaj.org/article/859912fa29444673b665f4b3783ea3bc