Structural Insight into the Self-Assembly of a Pharmaceutically Optimized Insulin Analogue Obtained by Small-Angle X-ray Scattering

Autor: Thomas Hoeg-Jensen, Lasse Sander Dreyer, Leila Malik, Rasmus Høiberg-Nielsen, Jesper Nygaard, Lise Arleth

Publikováno v: Molecular Pharmaceutics. 17:2809-2820

B29Ne-lithocholyl-γ-l-βGlu-desB30 human insulin [NN344] belongs to a group of insulins with fatty acid or sterol modifications. These insulin analogues have been found to form subcutaneous depots upon injection and hereby have a protracted release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcd5aa2aca0fe15a6d06f2e89877822
https://doi.org/10.1021/acs.molpharmaceut.0c00112

Chemical analysis and origin of the smell of line-dried laundry

Autor: Ole John Nielsen, Malte F. Jespersen, Justin Shenolikar, Jesper Nygaard, Silvia Pugliese, Matthew S. Johnson, Jakob Boyd Pernov

Publikováno v: Pugliese, S, Jespersen, M F, Pernov, J B, Shenolikar, J, Nygaard, J, Nielsen, O J & Johnson, M S 2020, ' Chemical analysis and origin of the smell of line-dried laundry ', Environmental Chemistry, vol. 17, no. 5, pp. 355-363 . https://doi.org/10.1071/EN19206

Environmental contextThe fresh pleasant smell of laundry dried outside in sunlight is recognised by most people, but despite decades of speculation the origin of the smell has not been demonstrated. We show that the smell of line-dried laundry is due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f7fa5139b62c6b7e1c2614f669ad1a
https://pure.au.dk/portal/da/publications/chemical-analysis-and-origin-of-the-smell-of-linedried-laundry(0627ca36-fe47-4426-836e-766a868cfeb4).html

FemtoMAX – an X-ray beamline for structural dynamics at the short-pulse facility of MAX IV

Autor: Erik Mansten, Å. U. J. Bengtsson, Lennart Isaksson, Francesca Curbis, Marija Kotur, Jörgen Larsson, Amélie Jarnac, Filip Lindau, Maher Harb, Xiaocui Wang, A. Jurgilaitis, J. Carl Ekström, Sverker Werin, Anna I.H. Persson, Van-Thai Pham, Erik Wallén, David Kroon, Christian Disch, Henrik Enquist, Sara Thorin, Jesper Nygaard, Michael Rissi, Chien Ming Tu, Matthias Burza

Publikováno v: Enquist, H, Jurgilaitis, A, Jarnac, A, Bengtsson, Å U J, Burza, M, Curbis, F, Disch, C, Ekström, J C, Harb, M, Isaksson, L, Kotur, M, Kroon, D, Lindau, F, Mansten, E, Nygaard, J, Persson, A I H, Pham, V T, Rissi, M, Thorin, S, Tu, C-M, Wallén, E, Wang, X, Werina, S & Larsson, J 2018, ' FemtoMAX – an X-ray beamline for structural dynamics at the short-pulse facility of MAX IV ', Journal of Synchrotron Radiation, vol. 25, pp. 570-579 . https://doi.org/10.1107/S1600577517017660
Journal of Synchrotron Radiation
Journal of Synchrotron Radiation, International Union of Crystallography, 2018, 25 (2), pp.570-579. ⟨10.1107/S1600577517017660⟩

The FemtoMAX beamline facilitates studies of the structural dynamics of materials on the femtosecond timescale. The first commissioning results are presented.
The FemtoMAX beamline facilitates studies of the structural dynamics of materials. Suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6450a0a444fb1ee3f5aab9f3ff6fd9b0
https://pure.au.dk/ws/files/121895687/ig5050.pdf

Perfluoroalkyl Chains Direct Novel Self-Assembly of Insulin

Autor: Knud J. Jensen, Thomas Hoeg-Jensen, Jesper Nygaard, Leila Malik, Lise Arleth, Rasmus Høiberg-Nielsen

Publikováno v: Langmuir. 28:593-603

The self-assembly of biopharmaceutical peptides into multimeric, nanoscale objects, as well as their disassembly to monomers, is central for their mode of action. Here, we describe a bioorthogonal strategy, using a non-native recognition principle, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b66a670fe7961da3a883000fff80c4a
https://doi.org/10.1021/la203042c

A de Novo-Designed Monomeric, Compact Three-Helix-Bundle Protein on a Carbohydrate Template

Autor: Knud J. Jensen, Peter W. Thulstrup, Lise Arleth, Werner Streicher, Leila Malik, Birthe B. Kragelund, Jesper Nygaard, Heike I. Rösner, Charlotte Madsen, Rasmus Høiberg-Nielsen, Niels J. Cristensen

Publikováno v: Chembiochem : a European journal of chemical biology. 16(13)

De novo design and chemical synthesis of proteins and of other artificial structures that mimic them is a central strategy for understanding protein folding and for accessing proteins with new functions. We have previously described carbohydrates tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec19ee004235bc75eaebdcd3a380c61
https://pubmed.ncbi.nlm.nih.gov/26147795