Detection of capillary abnormalities in early diabetic retinopathy using scanning laser ophthalmoscopy and optical coherence tomography combined with adaptive optics

Autor: Marie Elise Wistrup Torm, Michael Pircher, Sophie Bonnin, Jesper Johannesen, Oliver Niels Klefter, Mathias Falck Schmidt, Jette Lautrup Frederiksen, Nicolas Lefaudeux, Jordi Andilla, Claudia Valdes, Pablo Loza-Alvarez, Luisa Sanchez Brea, Danilo Andrade De Jesus, Kate Grieve, Michel Paques, Michael Larsen, Kiyoko Gocho

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract This study tested if a high-resolution, multi-modal, multi-scale retinal imaging instrument can provide novel information about structural abnormalities in vivo. The study examined 11 patients with very mild to moderate non-proliferative dia

Externí odkaz: https://doaj.org/article/676c9439b8bc439bab580766c1c33eea

Gene expression signature predicts rate of type 1 diabetes progressionResearch in context

Autor: Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo, Pieter Gillard, Kristina Casteels, Lutgart Overbergh, Chris Wallace, Mark Evans, Ajay Thankamony, Emile Hendriks, Loredana Marcoveccchio, Timothy Tree, Noel G. Morgan, Sarah Richardson, John A. Todd, Linda Wicker, Adrian Mander, Colin Dayan, Mohammad Alhadj Ali, Thomas Pieber, Decio L. Eizirik, Myriam Cnop, Flemming Pociot, Jesper Johannesen, Peter Rossing, Cristina Legido Quigley, Roberto Mallone, Raphael Scharfmann, Christian Boitard, Timo Otonkoski, Riitta Veijola, Matej Oresic, Jorma Toppari, Thomas Danne, Anette G. Ziegler, Peter Achenbach, Teresa Rodriguez-Calvo, Michele Solimena, Ezio E. Bonifacio, Stephan Speier, Reinhard Holl, Francesco Dotta, Francesco Chiarelli, Piero Marchetti, Emanuele Bosi, Stefano Cianfarani, Paolo Ciampalini, Carine De Beaufort, Knut Dahl-Jørgensen, Torild Skrivarhaug, Geir Joner, Lars Krogvold, Przemka Jarosz-Chobot, Tadej Battelino, Bernard Thorens, Martin Gotthardt, Bart O. Roep, Tanja Nikolic, Arnaud Zaldumbide, Ake Lernmark, Marcus Lundgren, Guillaume Costacalde, Thorsten Strube, Almut Nitsche, Jose Vela, Matthias Von Herrath, Johnna Wesley, Antonella Napolitano-Rosen, Melissa Thomas, Nanette Schloot, Allison Goldfine, Frank Waldron-Lynch, Jill Kompa, Aruna Vedala, Nicole Hartmann, Gwenaelle Nicolas, Jean van Rampelbergh, Nicolas Bovy, Sanjoy Dutta, Jeannette Soderberg, Simi Ahmed, Frank Martin, Esther Latres, Gina Agiostratidou, Anne Koralova, Ruben Willemsen, Anne Smith, Binu Anand, Vipan Datta, Vijith Puthi, Sagen Zac-Varghese, Renuka Dias, Premkumar Sundaram, Bijay Vaidya, Catherine Patterson, Katharine Owen, Barbara Piel, Simon Heller, Tabitha Randell, Tasso Gazis, Elise Bismuth Reismen, Jean-Claude Carel, Jean-Pierre Riveline, Jean-Francoise Gautier, Fabrizion Andreelli, Florence Travert, Emmanuel Cosson, Alfred Penfornis, Catherine Petit, Bruno Feve, Nadine Lucidarme, Jean-Paul Beressi, Catherina Ajzenman, Alina Radu, Stephanie Greteau-Hamoumou, Cecile Bibal, Thomas Meissner, Bettina Heidtmann, Sonia Toni, Birgit Rami-Merhar, Bart Eeckhout, Bernard Peene, N. Vantongerloo, Toon Maes, Leen Gommers

Publikováno v: EBioMedicine, Vol 92, Iss , Pp 104625- (2023)

Summary: Background: Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed to identify transcriptional changes associated with the disease progress

Externí odkaz: https://doaj.org/article/2c41bdea112542e1901b5cf0742fc2e4

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period

Autor: Caroline Frørup, Aashiq H. Mirza, Reza Yarani, Lotte B. Nielsen, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Christian Engelbrekt, Joachim Størling, Jesper Johannesen, Henrik B. Mortensen, Flemming Pociot, Simranjeet Kaur

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction. Several studies have highlighted the implication of circulating and exosomal m

Externí odkaz: https://doaj.org/article/091c3bd1c191443fa5000bef5683e9b7

Serial sampling of dried blood spots collected by a novel automated body-worn system, Fluispotter®

Autor: Jesper Krogh, Peter Plomgaard, Ruth Frikke-Schmidt, Sten Velschow, Jesper Johannesen, linda hilsted, Malene Schroeder, Ulla Feldt-Rasmussen

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13a2ca30ba7f5ce8b70bde8e32fc6ab8
https://doi.org/10.1530/endoabs.90.p439

The metabolic syndrome is frequent in children and adolescents with type 1 diabetes compared to healthy controls

Autor: Freja Barrett Mørk, Jens Otto Broby Madsen, Kasper Ascanius Pilgaard, Andreas Kryger Jensen, Heidi Klakk, Jakob Tarp, Anna Bugge, Malene Heidemann, Gerrit Van Hall, Flemming Pociot, Niels Wedderkopp, Jesper Johannesen

Publikováno v: Mørk, F B, Madsen, J O B, Pilgaard, K A, Jensen, A K, Klakk, H, Tarp, J, Bugge, A, Heidemann, M, Van Hall, G, Pociot, F, Wedderkopp, N & Johannesen, J 2022, ' The metabolic syndrome is frequent in children and adolescents with type 1 diabetes compared to healthy controls ', Pediatric Diabetes, vol. 23, no. 7, pp. 1064-1072 . https://doi.org/10.1111/pedi.13378
Mork, F B, Madsen, J O B, Pilgaard, K A, Jensen, A K, Klakk, H, Tarp, J, Bugge, A, Heidemann, M, Van Hall, G, Pociot, F, Wedderkopp, N & Johannesen, J 2022, ' The metabolic syndrome is frequent in children and adolescents with type 1 diabetes compared to healthy controls ', Pediatric Diabetes, vol. 23, no. 7, pp. 1064-1072 . https://doi.org/10.1111/pedi.13378

Objective: There is a rise in overweight and obesity among children and adolescents with type 1 diabetes (T1D) in parallel with the rise in the metabolic syndrome (MetS) among children and adolescents. The aim of the study was to describe the prevale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c712e555145c87d46e70e897fcab978
https://pure.au.dk/portal/da/publications/the-metabolic-syndrome-is-frequent-in-children-and-adolescents-with-type-1-diabetes-compared-to-healthy-controls(799137cc-59b9-4d35-86c9-869fe780b353).html