Neodymium-140 DOTA-LM3: Evaluation of an In Vivo Generator for PET with a Non-Internalizing Vector

Autor: Gregory W. Severin, Lotte K. Kristensen, Carsten H. Nielsen, Jesper Fonslet, Andreas I. Jensen, Anders F. Frellsen, K. M. Jensen, Dennis R. Elema, Helmut Maecke, Andreas Kjær, Karl Johnston, Ulli Köster

Publikováno v: Frontiers in Medicine, Vol 4 (2017)

140Nd (t1/2 = 3.4 days), owing to its short-lived positron emitting daughter 140Pr (t1/2 = 3.4 min), has promise as an in vivo generator for positron emission tomography (PET). However, the electron capture decay of 140Nd is chemically disruptive to

Externí odkaz: https://doaj.org/article/3d5c59ca104748f5831951e1f2c57d74

In Vivo Radionuclide Generators for Diagnostics and Therapy

Autor: Patricia E. Edem, Jesper Fonslet, Andreas Kjær, Matthias Herth, Gregory Severin

Publikováno v: Bioinorganic Chemistry and Applications, Vol 2016 (2016)

In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 2

Externí odkaz: https://doaj.org/article/86e0aef37d7f43ca8bf057c0696dea56

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo

Autor: Mikael Jensen, Matthias Gunzer, Philipp R. Spycher, Djamschid Solouk-Saran, Christopher R. Thornton, Mike Hasenberg, Martin Eichner, Bernd J. Pichler, Lauren S. Ryder, Anna-Maria Rolle, Stefan Wiehr, Jesper Fonslet, Adrien Dubois, Roger Schibli, Frédéric Boschetti, Genna Davies, Franck Denat, Claudia Schillinger, Andreas Maurer, Juliane Weski

Publikováno v: Theranostics
Theranostics, Ivyspring International Publisher, 2017, 7 (14), pp.3398-3414. 〈http://www.thno.org/v07p3398.htm〉. 〈10.7150/thno.20919〉
Davies, G, Rolle, A-M, Maurer, A, Spycher, P R, Schillinger, C, Solouk-Saran, D, Hasenberg, M, Weski, J, Fonslet, J, Dubois, A, Boschetti, F, Denat, F, Gunzer, M, Eichner, M, Ryder, L S, Jensen, M, Schibli, R, Pichler, B J, Wiehr, S & Thornton, C R 2017, ' Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo ', Theranostics, vol. 7, no. 14, pp. 3398-3414 . https://doi.org/10.7150/thno.20919
Theranostics, 7 (14)
Theranostics, Ivyspring International Publisher, 2017, 7 (14), pp.3398-3414. ⟨10.7150/thno.20919⟩

Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy or bone marrow transplant patients caused by the ubiquitous environmental fungus Aspergillus fumigatus. Current diagnostic tests for the disease lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11534a76147f07784219110c83f668b7
http://europepmc.org/articles/PMC5596432

Separation of Radiogallium from Zinc Using Membrane-Based Liquid-Liquid Extraction in Flow: Experimental and COSMO-RS Studies

Autor: Jesper Fonslet, Karin Michaelsen Nielsen, Kristina Søborg Pedersen, Mikael Jensen, Fedor Zhuravlev

Publikováno v: Pedersen, K S, Nielsen, K M, Fonslet, J, Jensen, M & Zhuravlev, F 2019, ' Separation of Radiogallium from Zinc Using Membrane-Based Liquid-Liquid Extraction in Flow: Experimental and COSMO-RS Studies ', Solvent Extraction and Ion Exchange, vol. 37, no. 5, pp. 376-391 . https://doi.org/10.1080/07366299.2019.1646982

A switch from batch to continuous manufacturing of gallium-68 (68Ga) and 68Ga-labeled pharmaceuticals can be advantageous, as it recycles isotopically-enriched zinc-68 (68Zn), removes pre- and post-irradiation target manipulations, and provides scala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737a58faac575549221eb2e98a0c0988
https://orbit.dtu.dk/en/publications/7943aa58-4447-4aa1-aab2-6693c4836dc3

A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium

Autor: Mikael Jensen, Gregory Severin, Andreas Tue Ingemann Jensen, Jesper Fonslet, Fedor Zhuravlev, Ulli Köster, Charlotte Busk Magnus

Publikováno v: Jensen, A I, Zhuravlev, F, Severin, G, Magnus, C B, Fonslet, J, Köster, U & Jensen, M 2020, ' A solid support generator of the Auger electron emitter rhodium-103m from [ 103 Pd]palladium ', Applied Radiation and Isotopes, vol. 156, 108985 . https://doi.org/10.1016/j.apradiso.2019.108985

Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74356358649376c4d4ef1c139ee06478
https://doi.org/10.1016/j.apradiso.2019.108985