Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jesline T Alexander-Chacko"'
Autor:
Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, Garron T Dodd, Frank Reimann, Fiona M Gribble, Emily C Beebe, James D Dunbar, Jesline T Alexander-Chacko, Dana K Sindelar, Tamer Coskun, Paul J Emmerson, Simon M Luckman
Publikováno v:
eLife, Vol 9 (2020)
The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 recept
Externí odkaz:
https://doaj.org/article/825a4f2bc81540a88d659e35ab6f5327
Autor:
Tamer Coskun, Claire H. Feetham, Giuseppe D'Agostino, Garron T. Dodd, Amy A. Worth, Frank Reimann, James D. Dunbar, Fiona M. Gribble, Simon M. Luckman, Paul J. Emmerson, Katie Tye, Emily C Beebe, Dana Sindelar, Jesline T. Alexander-Chacko, Rosemary Shoop
Publikováno v:
Worth, A A, Shoop, R, Tye, K, Feetham, C H, D'Agostino, G, Dodd, G T, Reimann, F, Gribble, F M, Beebe, E C, Dunbar, J D, Alexander-Chacko, J T, Sindelar, D K, Coskun, T, Emmerson, P J & Luckman, S M 2020, ' The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling ', eLife, vol. 9, e55164, pp. 1-19 . https://doi.org/10.7554/eLife.55164
eLife, Vol 9 (2020)
eLife
eLife, Vol 9 (2020)
eLife
The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c36fee4c12ae9aa6d1944526e39affe
Autor:
Katie Tye, Fiona M. Gribble, Amy A. Worth, Paul J. Emmerson, Jesline T. Alexander-Chacko, Tamer Coskun, Emily C Beebe, James D. Dunbar, Rosemary Shoop, Giuseppe D'Agostino, Dana Sindelar, Garron T. Dodd, Claire H. Feetham, Frank Reimann, Simon M. Luckman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39f2c4a0835c256636a335614171e764
https://doi.org/10.7554/elife.55164.sa2
https://doi.org/10.7554/elife.55164.sa2
Autor:
Timothy B. Durham, Jeffrey T. Dixon, James Lee Toth, Angela M. Siesky, Michael E. Christe, Valentine J. Klimkowski, Nathan A. Calvert, John F. Schindler, Dana Sindelar, Kyle W. Sloop, M. Dodson Michael, Jesline T. Alexander-Chacko, Julia X.C. Cao, Ginger Y. Wu, James E. McGee, Rachel N. Cavitt, Stefan Jon Thibodeaux, Sherry Y. Guo, Yong Wang, Michael J. Coghlan, Vladislav V. Kiselyov
Publikováno v:
Journal of Biological Chemistry. 290:20044-20059
Insulin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme implicated in proteolysis of insulin. Recently, a peptide inhibitor of IDE has been shown to affect levels of insulin, amylin, and glucagon in vivo. However, IDE(-/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b79e6dcdb0455d21e4b543d83d06c40
https://doi.org/10.1074/jbc.m115.638205
https://doi.org/10.1074/jbc.m115.638205
Autor:
Anne B. Need, Jesline T. Alexander-Chacko, Donald R. Gehlert, Dana Sindelar, Janice Shaw, Matthew W. Carson, Robert J. Barr, Michael J. Coghlan, Michelle Morin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:192-201
Weight gain and diabetes have been reported during treatment with atypical antipsychotic drugs (AAPDs). Patients treated with the glucocorticoid receptor antagonist (GRA) and the progesterone receptor antagonist (PRA) mifepristone [estra-4,9-dien-3-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0a3bb954856a4db9716ecb2d749835
https://doi.org/10.1124/jpet.113.205864
https://doi.org/10.1124/jpet.113.205864
Autor:
Allison E. Sahr, Michael A. Statnick, Charles H. Mitch, Dana Sindelar, Jesline T. Alexander-Chacko, Brian J. Eastwood
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 295:R463-R471
An analog of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine series (LY255582) exhibits high in vitro binding affinity and antagonist potency for the μ-, δ-, and κ-opioid receptors. In vivo, LY255582 exhibits potent effects in reducing food i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfc95bf546c02c46e1d467c4d46882c
https://doi.org/10.1152/ajpregu.00390.2007
https://doi.org/10.1152/ajpregu.00390.2007
Autor:
George G. Nomikos, Eyassu Chernet, Brian J. Eastwood, Richard J. Davis, Dana Sindelar, Lee A. Phebus, Anne B. Need, Jesline T. Alexander-Chacko
Publikováno v:
Psychopharmacology. 184:26-35
Cannabinoid type 1 (CB(1)) receptor antagonists are reportedly effective in reducing food intake both preclinically and clinically. This may be due in part to their effects on monoamine release in the brain. The level of central CB(1) receptor occupa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b39fa1d9db59439a8fc4e4a1284a1be
https://doi.org/10.1007/s00213-005-0234-x
https://doi.org/10.1007/s00213-005-0234-x
Autor:
Jesline T. Alexander-Chacko, Traci A. Czyzyk, Dana Sindelar, Michael A. Statnick, M. Joelle Dill
Publikováno v:
Neuromethods ISBN: 9781627031035
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334b70169b77891ad0b1b021be860993
https://doi.org/10.1007/978-1-62703-104-2_5
https://doi.org/10.1007/978-1-62703-104-2_5
Publikováno v:
Appetite.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07eae4a7a9417d88fb08d4b91c162fb0
https://doi.org/10.1016/j.appet.2006.03.198
https://doi.org/10.1016/j.appet.2006.03.198
Publikováno v:
Appetite.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d4d1365ddb661e74554d745e8aafd7
https://doi.org/10.1016/j.appet.2006.03.164
https://doi.org/10.1016/j.appet.2006.03.164