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Akademický článek

Striatonigral distribution of a fluorescent reporter following intracerebral delivery of genome editors

Autor: Samuel S. Neuman, Jeanette M. Metzger, Viktoriya Bondarenko, Yuyuan Wang, Jesi Felton, Jon E. Levine, Krishanu Saha, Shaoqin Gong, Marina E. Emborg

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Introduction: Targeted gene editing is proposed as a therapeutic approach for numerous disorders, including neurological diseases. As the brain is organized into neural networks, it is critical to understand how anatomically connected structures are

Externí odkaz: https://doaj.org/article/568a3d0fde4246ed896aee069eb68726

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Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

Autor: Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, Krishanu Saha, Jon Levine, Marina E. Emborg, Shaoqin Gong

Genome editing of somatic cells via clustered regularly interspaced short palindromic repeats (CRISPR) offers promise for new therapeutics to treat a variety of genetic disorders, including neurological diseases. However, the dense and complex parenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3377092d36e7a30c1410b12546007251
https://doi.org/10.1101/2022.07.24.501299