Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jeshina, Janardhanan"'
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry.
Externí odkaz:
https://doaj.org/article/8af1884ce4df43869295c061cce05605
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/5e27c6f2cc2e4fe0a5530d0d36badbf6
Autor:
Thor Ueland, Elisabeth Astrup, Kari Otterdal, Tove Lekva, Jeshina Janardhanan, John A J Prakash, Kurien Thomas, Annika E Michelsen, Pål Aukrust, George M Varghese, Jan K Damås
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009185 (2021)
BackgroundThe mechanisms that control local and systemic inflammation in scrub typhus have only been partially elucidated. The wingless (Wnt) signaling pathways are emerging as important regulators of inflammation and infection, but have not been inv
Externí odkaz:
https://doaj.org/article/06d867dd8990475b8b8dcf8df98f2e6c
Autor:
George M. Varghese, Vijay Prakash Turaka, Jeshina Janardhanan, Sadhana Yadav, Kavitha M. Lakshmi, Vijayakumar T. S, Bobby Cherayil
Publikováno v:
International Journal of Infectious Diseases, Vol 85, Iss , Pp 132-134 (2019)
Objectives: Mycobacterium tuberculosis produces high-affinity siderophores that play essential roles in iron acquisition and tuberculosis (TB) pathogenesis. In response, host cells secrete a siderophore-binding protein, siderocalin, to limit the bact
Externí odkaz:
https://doaj.org/article/59bc96411f7347b6af26e1f64e51460d
Autor:
Jeshina Janardhanan, Choon Kim, Yuanyuan Qian, Jingdong Yang, Jayda E. Meisel, Derong Ding, Enrico Speri, Valerie A. Schroeder, William R. Wolter, Allen G. Oliver, Shahriar Mobashery, Mayland Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Clostridioides difficile infection (CDI) is the most lethal of the five CDC urgent public health treats, resulting in 12,800 annual deaths in the United States alone [ Antibiotic Resistance Threats in the United States, 2019 (2019), www.cdc.gov/DrugR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5315e7eae115be15f759b068aa19d109
https://doi.org/10.1073/pnas.2304110120
https://doi.org/10.1073/pnas.2304110120
Autor:
George M. Varghese, Jeshina Janardhanan, Sanjay K. Mahajan, David Tariang, Paul Trowbridge, John A.J. Prakash, Thambu David, Sowmya Sathendra, O.C. Abraham
Publikováno v:
Emerging Infectious Diseases, Vol 21, Iss 1, Pp 64-69 (2015)
Scrub typhus, an acute febrile illness that is widespread in the Asia-Pacific region, is caused by the bacterium Orientia tsutsugamushi, which displays high levels of antigenic variation. We conducted an investigation to identify the circulating geno
Externí odkaz:
https://doaj.org/article/f6697c09be1a4003b03cefc3a801ba8d
Autor:
Divya Deodhar, George Varghese, Veeraraghavan Balaji, James John, Grace Rebekah, Jeshina Janardhanan, Ranjith Jeyaraman, Sudha Jasmine, Prasad Mathews
Publikováno v:
Journal of Global Infectious Diseases, Vol 7, Iss 3, Pp 97-102 (2015)
Introduction: Staphylococcus aureus (S. aureus) causes a variety of infections, ranging from a mild skin infection to blood stream infections and deep seated infections. As Stapylococcus aureus bacteremia (SAB) has the tendency to cause endovascular
Externí odkaz:
https://doaj.org/article/b0ffa4279d064c209dcc0d39cbdcb13c
Autor:
Mayland Chang, Enrico Speri, Valerie A. Schroeder, Elena Lastochkin, Cesar Masitas, Jeshina Janardhanan, Shahriar Mobashery, William R. Wolter, Jed F. Fisher
Publikováno v:
ACS Infectious Diseases. 6:2362-2368
A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. Clostridioides difficile is a Gram-positive bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f01523b20a6443800c50dd14abd7bf
https://doi.org/10.1021/acsinfecdis.0c00479
https://doi.org/10.1021/acsinfecdis.0c00479
Autor:
Kiran V. Mahasenan, Jeshina Janardhanan, Sara Tejera, Elena Lastochkin, Shahriar Mobashery, Yuanyuan Qian, William R. Wolter, Giuseppe Allegretta, Zhihong Peng, Melissa Malia N. Gozun, Mayland Chang, Rhona Feltzer, Valerie A. Schroeder
Publikováno v:
Journal of Medicinal Chemistry. 63:5287-5296
We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure-activity relationship (SAR) against methicillin-resistant Staphylococcus aureus (MRSA). Twenty one analogs were further evaluated in in vitro assays. Sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6291ab9052c87a4a8a8d6f64b0fe64be
https://doi.org/10.1021/acs.jmedchem.0c00153
https://doi.org/10.1021/acs.jmedchem.0c00153
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F.K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Human organ-on-a-chip (Organ-Chip) technology has the potential to disrupt preclinical drug discovery and improve success in drug development pipelines as it can recapitulate organ-level pathophysiology and clinical responses. The Innovation and Qual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a356d70f36120aa259a4974531c27107
https://doi.org/10.1101/2021.12.14.472674
https://doi.org/10.1101/2021.12.14.472674
