Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jes K. Klarlund"'
Autor:
Robert M. Q. Shanks, Eric G. Romanowski, John E. Romanowski, Katherine Davoli, Nancy A. McNamara, Jes K. Klarlund
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract Biologics are almost exclusively administered systemically, but localized delivery is preferable as it minimizes off-target exposure and allows more aggressive treatments. Topical application of biologics to epithelia is generally ineffectiv
Externí odkaz:
https://doaj.org/article/e531d3377b2743a18c3e0c7a3f926b03
Autor:
Jes K. Klarlund, Regis P. Kowalski, Nancy A. McNamara, Robert M. Q. Shanks, Jake D. Callaghan, Nicholas A. Stella
Publikováno v:
J Ocul Pharmacol Ther
Purpose: The combined activity of the tear film and blinking is remarkably efficient at removal of foreign materials from the ocular surface. This has prevented the use of certain classes of drugs for the treatment of ocular surface problems. We prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb12db6ab6e3b107f60ff86c41b8fc09
https://doi.org/10.1089/jop.2019.0065
https://doi.org/10.1089/jop.2019.0065
Publikováno v:
Cellular Signalling. 23:2051-2055
Wounding usually causes considerable cell damage, and released ATP promotes migration of nearby epithelium. ATP binds to purinergic receptors on the cell surface and induces transactivation of the EGF receptor through signaling by the Src family kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1a60e2a5382a17163eb860b2b2d4c3
https://doi.org/10.1016/j.cellsig.2011.07.021
https://doi.org/10.1016/j.cellsig.2011.07.021
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1810:875-878
Heparin-binding EGF-like growth factor (HB-EGF) contains, in contrast to EGF, a domain that binds to negatively charged glycans on cell surfaces and in extracellular matrix. We speculated that a short exposure to HB-EGF induces prolonged biological e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6743ea633b882070012f5e36dad9eeb1
https://doi.org/10.1016/j.bbagen.2011.05.011
https://doi.org/10.1016/j.bbagen.2011.05.011
Autor:
Ethan R. Block, Kira L. Lathrop, Rebecca S. Sullenberger, Michael A. Tolino, Jes K. Klarlund, Abigail R. Mazie, Jennifer S. Lozano
Publikováno v:
Molecular Biology of the Cell
Epithelia tend to migrate when edges are present, for instance, after wounding or during development. Using a new tissue culture model, we found that the existence of free edges is in itself a signal that causes activation of the epidermal growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0025a7b009d8de5f2a76a1fb5e7e5fd4
https://doi.org/10.1091/mbc.e09-12-1026
https://doi.org/10.1091/mbc.e09-12-1026
Autor:
Ethan R. Block, Jes K. Klarlund
Publikováno v:
Molecular Biology of the Cell. 19:4909-4917
Wounding epithelia induces activation of the epidermal growth factor receptor (EGFR), which is absolutely required for induction of motility. ATP is released from cells after wounding; it binds to purinergic receptors on the cell surface, and the EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b496cbde6fde25f832d003282e679e
https://doi.org/10.1091/mbc.e08-01-0097
https://doi.org/10.1091/mbc.e08-01-0097
Autor:
Xinyu Liu, Nicholas A. Stella, Kristin M. Hunt, Robert M. Q. Shanks, Eric G. Romanowski, Jes K. Klarlund
Publikováno v:
Scientific Reports
The epithelium provides a crucial barrier to infection and its integrity requires efficient wound healing. Bacterial cells and secretomes from a subset of tested species of bacteria inhibited human and porcine corneal epithelial cell migration in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1280a66f47022d4f0033fa243c0107
https://doi.org/10.1038/srep14003
https://doi.org/10.1038/srep14003
Publikováno v:
Journal of Cell Science. 119:1645-1654
Phospholipase D catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid, and there is currently much interest in elucidating messenger functions for this molecule. We report here that wounding sheets of corneal epithelial and Ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f9077fe6ff27919d0f9b424a76225a
https://doi.org/10.1242/jcs.02858
https://doi.org/10.1242/jcs.02858
Publikováno v:
Journal of Biological Chemistry. 279:24307-24312
Cellular responses to wounding have often been studied at a molecular level after disrupting cell layers by mechanical means. This invariably results in damage to cells at the edges of the wounds, which has been suggested to be instrumental for initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::247ff160cb18e5886350b10aee33139a
https://doi.org/10.1074/jbc.m401058200
https://doi.org/10.1074/jbc.m401058200
Autor:
Susan E. Lietzke, David G. Lambright, Thomas Charles Cronin, Jes K. Klarlund, Michael P. Czech, Sahana Bose, Anil Chawla
Publikováno v:
Molecular Cell. 6(2):385-394
Lipid second messengers generated by phosphoinositide (PI) 3-kinases regulate diverse cellular functions through interaction with pleckstrin homology (PH) domains in modular signaling proteins. The PH domain of Grp1, a PI 3-kinase-activated exchange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662d1aeb750ee7d3941e7db4d7033dd7