Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Jesús R. Requena"'
Autor:
Hasier Eraña, Carlos M. Díaz-Domínguez, Jorge M. Charco, Enric Vidal, Ezequiel González-Miranda, Miguel A. Pérez-Castro, Patricia Piñeiro, Rafael López-Moreno, Cristina Sampedro-Torres-Quevedo, Leire Fernández-Veiga, Juan Tasis-Galarza, Nuria L. Lorenzo, Aileen Santini-Santiago, Melisa Lázaro, Sandra García-Martínez, Nuno Gonçalves-Anjo, Maitena San-Juan-Ansoleaga, Josu Galarza-Ahumada, Eva Fernández-Muñoz, Samanta Giler, Mikel Valle, Glenn C. Telling, Mariví Geijó, Jesús R. Requena, Joaquín Castilla
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-30 (2023)
Abstract Among transmissible spongiform encephalopathies or prion diseases affecting humans, sporadic forms such as sporadic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms of the disease, these idiopathic forms oc
Externí odkaz:
https://doaj.org/article/63c13fcaea6249e3a04b3b8cea76b3ad
Autor:
Antonio Masone, Chiara Zucchelli, Enrico Caruso, Giada Lavigna, Hasier Eraña, Gabriele Giachin, Laura Tapella, Liliana Comerio, Elena Restelli, Ilaria Raimondi, Saioa R. Elezgarai, Federica De Leo, Giacomo Quilici, Lorenzo Taiarol, Marvin Oldrati, Nuria L. Lorenzo, Sandra García-Martínez, Alfredo Cagnotto, Jacopo Lucchetti, Marco Gobbi, Ilaria Vanni, Romolo Nonno, Michele A. Di Bari, Mark D. Tully, Valentina Cecatiello, Giuseppe Ciossani, Sebastiano Pasqualato, Eelco Van Anken, Mario Salmona, Joaquín Castilla, Jesús R. Requena, Stefano Banfi, Giovanna Musco, Roberto Chiesa
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108223- (2023)
Externí odkaz:
https://doaj.org/article/b54cc5dafd374331865a0f0374b0327f
Autor:
Enric Vidal, Manuel A. Sánchez-Martín, Hasier Eraña, Sonia Pérez Lázaro, Miguel A. Pérez-Castro, Alicia Otero, Jorge M. Charco, Belén Marín, Rafael López-Moreno, Carlos M. Díaz-Domínguez, Mariví Geijo, Montserrat Ordóñez, Guillermo Cantero, Michele di Bari, Nuria L. Lorenzo, Laura Pirisinu, Claudia d’Agostino, Juan María Torres, Vincent Béringue, Glenn Telling, Juan J. Badiola, Martí Pumarola, Rosa Bolea, Romolo Nonno, Jesús R. Requena, Joaquín Castilla
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Atypical Scrapie, which is not linked to epidemics, is assumed to be an idiopathic spontaneous prion disease in small ruminants. Therefore, its occurrence is unlikely to be controlled through selective breeding or other strategies as it is d
Externí odkaz:
https://doaj.org/article/ec75bdeb108f452fac8587687f697f39
Autor:
Giovanni Spagnolli, Tania Massignan, Andrea Astolfi, Silvia Biggi, Marta Rigoli, Paolo Brunelli, Michela Libergoli, Alan Ianeselli, Simone Orioli, Alberto Boldrini, Luca Terruzzi, Valerio Bonaldo, Giulia Maietta, Nuria L. Lorenzo, Leticia C. Fernandez, Yaiza B. Codeseira, Laura Tosatto, Luise Linsenmeier, Beatrice Vignoli, Gianluca Petris, Dino Gasparotto, Maria Pennuto, Graziano Guella, Marco Canossa, Hermann C. Altmeppen, Graziano Lolli, Stefano Biressi, Manuel M. Pastor, Jesús R. Requena, Ines Mancini, Maria L. Barreca, Pietro Faccioli, Emiliano Biasini
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cel
Externí odkaz:
https://doaj.org/article/e109df8e1973483785b0d57e6d79e2af
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/dd7ca6d479cc4f02b5956853563c1ebf
Autor:
Giovanni Spagnolli, Marta Rigoli, Giovanni Novi Inverardi, Yaiza B. Codeseira, Emiliano Biasini, Jesús R. Requena
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Deformed templating is the process by which self-replicating protein conformations with a given cross-β folding pattern can seed formation of an alternative self-replicating state with different cross-β folding pattern. In particular, uninfectious
Externí odkaz:
https://doaj.org/article/2e68c5d5b37f47269f12e743401bc572
Autor:
Sofía Sánchez-Iglesias, Antía Fernández-Pombo, Silvia Cobelo-Gómez, Álvaro Hermida-Ameijeiras, Helena Alarcón-Martínez, Rosario Domingo-Jiménez, Alejandro Iván Ruíz Riquelme, Jesús R. Requena, David Araújo-Vilar
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 7, p 1435 (2021)
Seipin, encoded by the BSCL2 gene, is a protein that in humans is expressed mainly in the central nervous system. Uniquely, certain variants in BSCL2 can cause both generalized congenital lipodystrophy type 2, upper and/or lower motor neuron diseases
Externí odkaz:
https://doaj.org/article/577fad1a527e439e8de1aa7add3f7c97
Autor:
Alejandro Ruiz-Riquelme, Sofía Sánchez-Iglesias, Alberto Rábano, Encarna Guillén-Navarro, Rosario Domingo-Jiménez, Adriana Ramos, Isaac Rosa, Ana Senra, Peter Nilsson, Ángel García, David Araújo-Vilar, Jesús R. Requena
Publikováno v:
Neurobiology of Disease, Vol 83, Iss , Pp 44-53 (2015)
Celia's Encephalopathy (MIM #615924) is a recently discovered fatal neurodegenerative syndrome associated with a new BSCL2 mutation (c.985C>T) that results in an aberrant isoform of seipin (Celia seipin). This mutation is lethal in both homozygosity
Externí odkaz:
https://doaj.org/article/0eeb5282a371446a80ac9d94445bca0a
Autor:
Adriana Ramos, Carmen Rodríguez-Seoane, Isaac Rosa, Irantzu Gorroño-Etxebarria, Jana Alonso, Sonia Veiga, Carsten Korth, Robert M. Kypta, Ángel García, Jesús R. Requena
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 119 (2018)
A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia. Since the discovery of this translocation, many studies h
Externí odkaz:
https://doaj.org/article/3291d69987b84a4ea887425c45377057
Autor:
Holger Wille, Jesús R. Requena
Publikováno v:
Pathogens, Vol 7, Iss 1, p 20 (2018)
PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer
Externí odkaz:
https://doaj.org/article/6a46b21943524c4ab0dfb43c76af37e0