Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Jesús M. Pradillo"'
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Neutrophil β
Autor: Agustín, Clemente-Moragón, Eduardo, Oliver, Daniel, Calle, Lorena, Cussó, Mónica, Gómez, Jesús M, Pradillo, Raquel, Castejón, Norma, Rallón, José M, Benito, José C, Fernández-Ferro, Joaquín, Carneado-Ruíz, María A, Moro, Javier, Sánchez-González, Valentín, Fuster, Marta, Cortés-Canteli, Manuel, Desco, Borja, Ibáñez
Publikováno v: British journal of pharmacologyREFERENCES.
Reperfusion therapy is the standard of care for ischaemic stroke; however, there is a need to identify new therapeutic targets able to ameliorate cerebral damage. Neutrophil βRats were subjected to middle cerebral artery occlusion-reperfusion to eva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::317f18a73db010b2a9153b8758483f66
https://pubmed.ncbi.nlm.nih.gov/36181002
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4
Toll-like receptor 4 regulates subventricular zone proliferation and neuroblast migration after experimental stroke
Autor: Jesús M. Pradillo, Raquel Ferreras-Martín, Isaac García-Yébenes, Ana Moraga, Olivia Hurtado, María A. Moro, Alicia García-Culebras, Ignacio Lizasoain, Sara Palma-Tortosa
Publikováno v: Brain, Behavior, and Immunity. 80:573-582
Ischemic stroke is one of the leading causes of death and disability with an urgent need for innovative therapies, especially targeting the chronic phase. New evidence has emerged showing that Toll-Like Receptor 4 (TLR4), a key mediator of brain dama
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd686fe086f58387f885d62254276b09
https://doi.org/10.1016/j.bbi.2019.05.002
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5
Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry
Autor: Jesús M. Pradillo, Hervé Boutin, Fiona Henderson, Michael Kassiou, Philippa J. Hart, Lidan Christie, Adam McMahon, Kaye J. Williams
Publikováno v: Henderson, F, Hart, P J, Pradillo, J M, Kassiou, M, Christie, L, Williams, K J, Boutin, H & McMahon, A 2018, ' Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry ', Rapid Communications in Mass Spectrometry, vol. 32, no. 9, pp. 721-729 . https://doi.org/10.1002/rcm.8090
RATIONALE: Stroke is a leading cause of disability worldwide. Understanding the recovery process post-stroke is essential; however, longer-term recovery studies are lacking. In vivo positron emission tomography (PET) can image biological recovery pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a94233abd14037a23a7b12ba73b0ec7
https://doi.org/10.1002/rcm.8090
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6
Specific Features of SVZ Neurogenesis After Cortical Ischemia: a Longitudinal Study
Autor: Alberto Pérez-Ruiz, Violeta Durán-Laforet, Sara Palma-Tortosa, Olivia Hurtado, A. Moraga, Alicia García-Culebras, María Isabel Cuartero, María A. Moro, Jesús M. Pradillo, J. de la Parra, Ignacio Lizasoain
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports
Stroke is a devastating disease with an increasing prevalence. Part of the current development in stroke therapy is focused in the chronic phase, where neurorepair mechanisms such as neurogenesis, are involved. In the adult brain, one of the regions
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940d4e36aebcd618c4f9536d125461a4
http://link.springer.com/article/10.1038/s41598-017-16109-7
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7
Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography
Autor: Jordi Llop, Makoto Higuchi, María A. Moro, Ana Moraga, Jesús M. Pradillo, María Isabel Cuartero, Boguslaw Szczupak, Ignacio Lizasoain, Vanessa Gómez-Vallejo, Eneko San Sebastián, Abraham Martín, Irati Markuerkiaga
Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3′-deoxy-3′
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34eb5f52ca746ea9209687016759ceea
https://doi.org/10.1177/0271678x15627657
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8
TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models
Autor: M. Irene Ayuso, Macarena Hernández-Jiménez, María Isabel Cuartero, M. Elena Martín, Ana Moraga, Víctor M. González, Rafael Gonzalo-Gobernado, Alicia García-Culebras, María A. Moro, Silvia Sacristán, Ignacio Lizasoain, David Fernández-López, Jesús M. Pradillo, Carolina Peña-Martínez, Gerónimo Fernández
Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Since Toll-like receptor 4 (TLR4) mediates brain damage after stroke, development of TLR4 antagonists is a promising therapeutic strategy for this disease. Our aim was to generate TLR4-blocking DNA aptamers to be used for stroke treatment. From a ran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee3b6d15edada0e9d6261d21a31d0a9
http://www.cell.com/article/S1525001618302223/pdf
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9
Myeloid cells as therapeutic targets in neuroinflammation after stroke: Specific roles of neutrophils and neutrophil-platelet interactions
Autor: Alicia García-Culebras, Jaime Díaz-Guzmán, Ignacio Lizasoain, Violeta Durán-Laforet, Iván Ballesteros, María A. Moro, Jesús M. Pradillo, Carolina Peña-Martínez
Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Ischemic brain injury causes a local inflammatory response, involving the activation of resident brain cells such as microglia and the recruitment of infiltrating immune cells. Increasing evidence supports that plasticity of the myeloid cell lineage
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0eb1ff02ef247f2cf1ad843c67f232
https://saludmadrid.ibai.com/handle/20.500.12530/35782
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10
A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke
Autor: Adam Denes, Nancy J. Rothwell, Philip M.W. Bath, Denis Vivien, Hiramani Dhungana, Jari Koistinaho, Markus Schwaninger, Mahbubur Rahman, Tarja Malm, Marina Rubio, Raymond C.B. Wong, Samaneh Maysami, Cyrille Orset, Stuart M. Allan, Jesús M. Pradillo
Publikováno v: Journal of Cerebral Blood Flow & Metabolism
Maysami, S, Wong, R, Pradillo, J M, Denes, A, Dhungana, H, Malm, T, Koistinaho, J, Orset, C, Rahman, M, Rubio, M, Schwaninger, M, Vivien, D, Bath, P M, Rothwell, N J & Allan, S M 2015, ' A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. ', Journal of Cerebral Blood Flow and Metabolism, vol. 36, no. 3, pp. 596-605 . https://doi.org/10.1177/0271678X15606714
Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695b1e04dcadfcbd1db80a84d997cc83
http://europepmc.org/articles/PMC4776311
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