Výsledky vyhledávání - "Jesús Llenas"

Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile

Autor: Amadeu Gavaldà, Jesús Llenas, Jordi Gras, Jorge Beleta, Jordi Aubets, Josep Llupià

Publikováno v: Life Sciences. 90:301-305

Aclidinium bromide is a novel, long-acting, inhaled muscarinic antagonist currently in registration phase for the treatment of chronic obstructive pulmonary disease. Since urinary difficulty and retention have been reported for anticholinergic agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eda5f2676f1a0807759961b9b1db5d7
https://doi.org/10.1016/j.lfs.2011.12.002

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Safety Profile of Almotriptan, a New Antimigraine Agent

Autor: Jordi Gras, Jesús Llenas, José Palacios, Josep Llupià

Publikováno v: Arzneimittelforschung. 51:726-732

Almotriptan (3- [2- (dimethylamino) ethyl] -5- (Pyrrolidin-1 -ylsulfonylmethyl) -1H-indole, CAS 154323-57-6) is a new 5-HT 1B/1d agonist whose clinical efficacy has been demonstrated in Phase III clinical trials. This study aimed to evaluate the safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ab748349e33705b6e2ccef6445e059d
https://doi.org/10.1055/s-0031-1300106

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Almotriptan, a New Anti-Migraine Agent: A Review

Autor: Xavier Cabarrocas, Josep M. Jansat, José Palacios, José Jáuregui, Jesús Llenas, Jordi Gras

Publikováno v: CNS Drug Reviews. 8:217-234

Almotriptan is a new anti‐migraine agent with nanomolar affinity for human 5‐HT(1B), 5‐HT(1D), and 5‐HT(1F) receptors, weak affinity for 5‐HT(1A) and 5‐HT(7) receptors and no significant affinity for more than 20 other pharmacological rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3f803d4d8b5bfb2307e2d9da25292a
https://doi.org/10.1111/j.1527-3458.2002.tb00226.x

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Synthesis and pharmacological evaluationof 2,3-dihydro-3-oxo-4H-thieno[3,4-e][1,2,4]thiadiazine 1,1-dioxidesas voltage-dependent calcium channel blockers

Autor: Andrés Fernández, Esther Arranz, J. A. Diaz, Jesús Llenas, Ignasi Cardelús, Salvador Vega, Francisco Orallo, Manuel Campos-Toimil

Publikováno v: European Journal of Medicinal Chemistry. 35:751-759

The synthesis of a novel series of 2,3-dihydro-3-oxo-4 H -thieno[3,4- e ][1,2,4]thiadiazine 1,1-dioxides and their pharmacological evaluation as drugs with effects on the rat cardiovascular system are described. The compounds under study were synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8336739fca2648eddc769f6800888ee
https://doi.org/10.1016/s0223-5234(00)00188-4

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Cardiotoxicity of Histamine and the Possible Role of Histamine in the Arrhythmogenesis Produced by Certain Antihistamines

Autor: I. Cardelús, F. De Mora, Robert William Gristwood, A. Heredia, Jesús Llenas

Publikováno v: Scopus-Elsevier

Since 1990 it has repeatedly been reported that some histamine H1 receptor antagonists (e.g. terfenadine and astemizole) are able to produce ventricular arrhythmias (e.g. torsade de pointes) when they are given at dosages above the therapeutic range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54676e0e734658cfd0a84b5b5afe053
https://doi.org/10.2165/00002018-199921001-00005

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Synthesis of nonsymmetrically 3,4-disubstituted 1,2,5-thiadiazole dioxides

Autor: Ana I. Gómez de Castro, Vicente J. Arán, Jesús Llenas, Ignacio Cardelús, Ana Martínez, José Palacios

Publikováno v: Journal of Heterocyclic Chemistry. 35:297-300

A synthetic pathway for obtaining arylamino, alkylamino 3,4-disubstituted 1,2,5-thiadiazole dioxide derivatives has been developed. This methodology could be applied to obtain potential biologically active molecules.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06bff1b6919cf16c8f2e5e1a4ed394f5
https://doi.org/10.1002/jhet.5570350206

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ChemInform Abstract: Synthesis and Pharmacological Evaluation of 2,3-Dihydro-3-oxo-4H-thieno[3,4-e][1,2,4]thiadiazine 1,1-Dioxides as Voltage-Dependent Calcium Channel Blockers

Autor: Jesús Llenas, Francisco Orallo, Salvador Vega, Manuel Campos-Toimil, Esther Arranz, Andrés Fernández, Ignasi Cardelús, J. A. Diaz

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cea6d963c4c77f33f6e70230bf79bbe2
https://doi.org/10.1002/chin.200046175

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