Zobrazeno 1 - 10 of 49 pro vyhledávání: '"Jesús Lacal"'
1
Akademický článek
NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death
Autor: Francisco J. Martínez-Morcillo, Joaquín Cantón-Sandoval, Francisco J. Martínez-Navarro, Isabel Cabas, Idoya Martínez-Vicente, Joy Armistead, Julia Hatzold, Azucena López-Muñoz, Teresa Martínez-Menchón, Raúl Corbalán-Vélez, Jesús Lacal, Matthias Hammerschmidt, José C. García-Borrón, Alfonsa García-Ayala, María L. Cayuela, Ana B. Pérez-Oliva, Diana García-Moreno, Victoriano Mulero
Publikováno v: PLoS Biology, Vol 19, Iss 11 (2021)
Several studies have revealed a correlation between chronic inflammation and nicotinamide adenine dinucleotide (NAD+) metabolism, but the precise mechanism involved is unknown. Here, we report that the genetic and pharmacological inhibition of nicoti
Externí odkaz: https://doaj.org/article/7eee5ee7fb2a4382a2dfaadd0d7636f1
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2
Integrated in silico MS-based phosphoproteomics and network enrichment analysis of RASopathy proteins
Autor: Javier-Fernando Montero-Bullón, María Isidoro-García, Óscar González-Velasco, Jesús Lacal
Publikováno v: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-17 (2021)
Orphanet Journal of Rare Diseases
Background RASopathies are a group of syndromes showing clinical overlap caused by mutations in genes affecting the RAS-MAPK pathway. Consequent disruption on cellular signaling leads and is driven by phosphoproteome remodeling. However, we still lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cae85c81a2be0db50011edc0dfe0d66
https://doaj.org/article/c12e4fcf2bed471a8c101c44342df7bf
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3
Dictyostelium discoideum as a non‐mammalian biomedical model
Autor: Javier Martín-González, Javier-Fernando Montero-Bullón, Jesús Lacal
Publikováno v: Microbial Biotechnology
Microbial Biotechnology, Vol 14, Iss 1, Pp 111-125 (2021)
This MS opens a window to the general audience on the potential of Dictyostelium as a model microbe in biomedicine.
Summary Dictyostelium discoideum is one of eight non‐mammalian model organisms recognized by the National Institute of Health f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003a25746bf018f93538848f59d52fda
https://doi.org/10.1111/1751-7915.13692
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4
NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death
Autor: Julia Hatzold, Alfonsa García-Ayala, José C. García-Borrón, Azucena López-Muñoz, Matthias Hammerschmidt, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Navarro, Diana García-Moreno, Idoya Martínez-Vicente, Ana B. Pérez-Oliva, Joaquín Cantón-Sandoval, Jesús Lacal, Isabel Cabas, Joy Armistead, Raúl Corbalán-Vélez, María L. Cayuela, Teresa Martínez-Menchón, Victoriano Mulero
Publikováno v: PLoS Biology
PLoS Biology, Vol 19, Iss 11, p e3001455 (2021)
PLoS Biology, Vol 19, Iss 11 (2021)
Several studies have revealed a correlation between chronic inflammation and nicotinamide adenine dinucleotide (NAD+) metabolism, but the precise mechanism involved is unknown. Here, we report that the genetic and pharmacological inhibition of nicoti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3642e53c033ed80d94c149af338b03b2
https://pubmed.ncbi.nlm.nih.gov/34748530
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7
Phosphodiesterase PdeD, dynacortin, and a Kelch repeat-containing protein are direct GSK3 substrates inDictyosteliumthat contribute to chemotaxis towards cAMP
Autor: Kimberly Baumgardner, Richard A. Firtel, Jesús Lacal, Connie Lin
Publikováno v: Environmental Microbiology. 20:1888-1903
The migration of cells according to a diffusible chemical signal in their environment is called chemotaxis, and the slime mold Dictyostelium discoideum is widely used for the study of eukaryotic chemotaxis. Dictyostelium must sense chemicals, such as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5323131110ff28647e386a82b212f03b
https://doi.org/10.1111/1462-2920.14126
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8
Akademický článek
Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells
Autor: Sheila González-Salvatierra, Cristina García-Fontana, Jesus Lacal, Francisco Andújar-Vera, Luis Martínez-Heredia, Raquel Sanabria-de la Torre, María Ferrer-Millán, Enrique Moratalla-Aranda, Manuel Muñoz-Torres, Beatriz García-Fontana
Publikováno v: Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-20 (2023)
Abstract Background Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs). Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular di
Externí odkaz: https://doaj.org/article/89c488bf17db4b2f997788a443cc6bff
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9
Proteomic and Transcriptomic Profiling Identifies Early Developmentally Regulated Proteins in Dictyostelium Discoideum
Autor: Óscar González-Velasco, Jesús Lacal, Javier De Las Rivas
Publikováno v: Cells, Vol 8, Iss 10, p 1187 (2019)
Cells
Digital.CSIC. Repositorio Institucional del CSIC
instname
Volume 8
Issue 10
© 2019 by the authors.
Cyclic AMP acts as a secondary messenger involving different cellular functions in eukaryotes. Here, proteomic and transcriptomic profiling has been combined to identify novel early developmentally regulated proteins in e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b695c4ceb84b8bd507b9cde1c15fc02
https://www.mdpi.com/2073-4409/8/10/1187
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10
Akademický článek
Biomarker Landscape in RASopathies
Autor: Noemi Ferrito, Juan Báez-Flores, Mario Rodríguez-Martín, Julián Sastre-Rodríguez, Alessio Coppola, María Isidoro-García, Pablo Prieto-Matos, Jesus Lacal
Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 16, p 8563 (2024)
RASopathies are a group of related genetic disorders caused by mutations in genes within the RAS/MAPK signaling pathway. This pathway is crucial for cell division, growth, and differentiation, and its disruption can lead to a variety of developmental
Externí odkaz: https://doaj.org/article/77a15fd02540400c99f020faeb01582e
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