Zobrazeno 1 - 10 of 102 pro vyhledávání: '"Jesús Joglar"'
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Akademický článek
Treatment with a novel oleic-acid–dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats
Autor: Juan M. Decara, Francisco Javier Pavón, Juan Suárez, Miguel Romero-Cuevas, Elena Baixeras, Mariam Vázquez, Patricia Rivera, Ana L. Gavito, Bruno Almeida, Jesús Joglar, Rafael de la Torre, Fernando Rodríguez de Fonseca, Antonia Serrano
Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1213-1225 (2015)
Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized the in vivo effects of
Externí odkaz: https://doaj.org/article/ebb5fca10a7f4afe894c0f7ce9aec7f1
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2
A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
Autor: Jofre Font-Mateu, Pol Sanllehí, Jesús Sot, Beatriz Abad, Nicolas Mateos, Juan Andres Torreno-Pina, Roberto Ferrari, Roni H.G. Wright, Maria Garcia-Parajo, Jesús Joglar, Félix M. Goñi, Miguel Beato
In hormone-responsive breast cancer cells, progesterone (P4) has been shown to act via its nuclear receptor (PR), a ligand-activated transcription factor. A small fraction of PR is palmitoylated and anchored to the cell membrane (mbPR) forming a comp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54486e29560bf0432222f0c80734f68e
https://doi.org/10.1101/2023.05.14.540708
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3
Biocatalytic Synthesis of Homochiral 2-Hydroxy-4-butyrolactone Derivatives by Tandem Aldol Addition and Carbonyl Reduction
Autor: Carlos J. Moreno, Karel Hernández, Samantha Gittings, Michael Bolte, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés
Chiral 2-hydroxy acids and 2-hydroxy-4-butyrolactone derivatives are structural motifs often found in fine and commodity chemicals. Here, we report a tandem biocatalytic stereodivergent route for the preparation of these compounds using three stereos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f15b30a567f54530a31b8b6d5f2619
https://api.elsevier.com/content/abstract/scopus_id/85152201605
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4
Trapping of Cyclopropenyl Radicals by 5,5-Dimethyl-1-pyrroline
Autor: Montserrat, Cano, Jordi, Quintana, Luís, Juliá, Francisco, Camps, Jesús, Joglar
Publikováno v: The Journal of organic chemistry. 64(14)
The possible generation of cyclopropenyl radicals by ultraviolet irradiation of different cyclopropenyl derivatives in fluid solution and in the presence of 5,5-dimethyl-1-pyrroline
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::834a65ac4be94158207ff46bec8707ae
https://pubmed.ncbi.nlm.nih.gov/34237837
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5
Chemoenzymatic Production of Enantiocomplementary 2‐Substituted 3‐Hydroxycarboxylic Acids from l‐α‐Amino Acids
Autor: Mathias Pickl, Jordi Bujons, Roser Marín-Valls, Pere Clapés, Jesús Joglar
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Advanced synthesis & catalysis
A two‐enzyme cascade reaction plus in situ oxidative decarboxylation for the transformation of readily available canonical and non‐canonical l‐α‐amino acids into 2‐substituted 3‐hydroxycarboxylic acid derivatives is described. The biocat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580e1b3a87a96df10b67023bf33e30d8
http://hdl.handle.net/10261/236599
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6
Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition–Transamination Reactions
Autor: Samantha Gittings, Jesús Joglar, Pere Clapés, Jordi Bujons, Simon J. Charnok, Karel Hernández, Carlos J. Moreno, Teodor Parella, Michael Bolte
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ACS Catalysis
Three enzymatic routes toward γ-hydroxy-α-amino acids by tandem aldol addition–transamination one-pot two-step reactions are reported. The approaches feature an enantioselective aldol addition of pyruvate to various nonaromatic aldehydes catalyze
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb91843675455edb97c93cc67f511ae
http://hdl.handle.net/10261/236791
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7
Biocatalytic Construction of Quaternary Centers by Aldol Addition of 3,3-Disubstituted 2-Oxoacid Derivatives to Aldehydes
Autor: Karel Hernández, Pere Clapés, Teodor Parella, Jordi Bujons, Roser Marín-Valls, Michael Bolte, Jesús Joglar
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
The congested nature of quaternary carbons hinders their preparation, most notably when stereocontrol is required. Here we report a biocatalytic method for the creation of quaternary carbon centers with broad substrate scope, leading to different com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36e159ccb8c7e9bd71747bff124e060
http://hdl.handle.net/10261/222563
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8
Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes
Autor: Jesús Joglar, Christine Guérard-Hélaine, Marielle Lemaire, Israel Sánchez-Moreno, Virgil Hélaine, Wolf-Dieter Fessner, Pere Clapés, Raquel Roldan, Karel Hernández, Jordi Bujons, Teodor Parella
Publikováno v: ACS Catalysis
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ACS Catalysis, American Chemical Society, 2018, 8 (9), pp.8804-8809. ⟨10.1021/acscatal.8b02486⟩
ACS Catalysis, 2018, 8 (9), pp.8804-8809. ⟨10.1021/acscatal.8b02486⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Asymmetric aldol addition of simple aldehydes and ketones to electrophiles is a cornerstone reaction for the synthesis of unusual sugars and chiral building blocks. We investigated D-fructose-6-phosphate aldolase from E. coli (FSA) D6X variants as ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed139a1723dac8151b6694d55cdaa04
http://europepmc.org/articles/PMC6135579
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9
2-Keto-3-Deoxy-l-Rhamnonate Aldolase (YfaU) as Catalyst in Aldol Additions of Pyruvate to Amino Aldehyde Derivatives
Autor: Karel Hernández, Teodor Parella, Jesús Joglar, Ariadna Gómez, Pere Clapés, Jordi Bujons
Publikováno v: Advanced Synthesis & Catalysis
Digital.CSIC. Repositorio Institucional del CSIC
instname
4-Hydroxy-2-ketoacid derivatives are versatile building blocks for the synthesis of amino acids, hydroxy carboxylic acids and chiral aldehydes. Pyruvate aldolases are privileged catalysts for a straightforward access to this class of ketoacid compoun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5663911cb58931a23ffcd080260a343
https://doi.org/10.1002/adsc.201700360
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10
Intramolecular Benzoin Reaction Catalyzed by Benzaldehyde Lyase from Pseudomonas Fluorescens Biovar I
Autor: Giovanna Petrillo, Jordi Bujons, Karel Hernández, Teodor Parella, Jesús Joglar, Pere Clapés, Claudia M. Wandtke, Isabel Usón
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Intramolecular benzoin reactions catalyzed by benzaldehyde lyase from Pseudomonas fluorescens biovar I (BAL) are reported. The structure of the substrates envisaged for this reaction consists of two benzaldehyde derivatives linked by an alkyl chain.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2588f60ab9b5c03b1891bf4bcb1b75df
https://doi.org/10.1002/anie.201702278
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