Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jesús Hernández-Cascales"'
Autor:
Ramón Aranda-Domene, Esteban Orenes-Piñero, José María Arribas-Leal, Sergio Canovas-Lopez, Jesús Hernández-Cascales
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Glucagon is thought to increase heart rate and contractility by stimulating glucagon receptors and increasing 3′,5′-cyclic adenosine monophosphate (cAMP) production in the myocardium. This has been confirmed in animal studies
Externí odkaz:
https://doaj.org/article/0828f01fdbdd4845bce98e15da89ead2
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132884 (2015)
This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in t
Externí odkaz:
https://doaj.org/article/2a4cbefeef0f4fd0b742b1298afa5542
Autor:
Jesús Hernández-Cascales
Publikováno v:
Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-4 (2018)
Cardiovascular Diabetology
Cardiovascular Diabetology
Glucagon is considered to exert cardiostimulant effects, most notably the enhancement of heart rate and contractility, due to the stimulation of glucagon receptors associated with Gs protein stimulation which causes adenylyl cyclase activation and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd474a0ddb726d2560935c6728894f0
http://link.springer.com/article/10.1186/s12933-018-0791-z
http://link.springer.com/article/10.1186/s12933-018-0791-z
Publikováno v:
European Journal of Pharmacology. 765:429-436
Cyclic nucleotide phosphodiesterase (PDE)3 and PDE4 provide the major PDE activity in cardiac myocytes and shape β1-adrenoceptor-dependent cardiac cAMP signaling but their role in regulating β2-adrenoceptor-mediated responses is less well known. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f176a314ee6742037bfeaafe38037b9f
https://doi.org/10.1016/j.ejphar.2015.09.001
https://doi.org/10.1016/j.ejphar.2015.09.001
Autor:
Christoph Handschin, Jesús Hernández-Cascales, Francisco Fernandez-Belda, Joaquín Pérez-Schindler, Teodomiro Fuente, Fernando Soler
Publikováno v:
Experimental Biology and Medicine. 240:1205-1213
The important regulator of cardiac function, cAMP, is hydrolyzed by different cyclic nucleotide phosphodiesterases (PDEs), whose expression and activity are not uniform throughout the heart. Of these enzymes, PDE2 shapes β1 adrenoceptor-dependent ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add296233dc1653ab235281b172dbef1
https://doi.org/10.1177/1535370214560969
https://doi.org/10.1177/1535370214560969
Autor:
Jesús Hernández-Cascales
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 103:4478-4479
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b2a75e187ba2103d2fdfad9ab5ff9ec
https://doi.org/10.1210/jc.2018-01601
https://doi.org/10.1210/jc.2018-01601
Publikováno v:
European Journal of Pharmacology. 698:39-47
β-adrenoceptors are members of the G protein-coupled receptor superfamily which play a key role in the regulation of myocardial function. Their activation increases cardiac performance but can also induce deleterious effects such as cardiac arrhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bb5088d4af2a2afa4fcf6065c045f7
https://doi.org/10.1016/j.ejphar.2012.11.001
https://doi.org/10.1016/j.ejphar.2012.11.001
Autor:
Jesús Hernández-Cascales
Publikováno v:
PeerJ
PeerJ, Vol 5, p e3113 (2017)
PeerJ, Vol 5, p e3113 (2017)
BackgroundResveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity. Thus, it is possible that resveratrol increases the inotropic effect of sympathomimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36817914a5584600b0b4ac88f0d71be0
https://pubmed.ncbi.nlm.nih.gov/28382232
https://pubmed.ncbi.nlm.nih.gov/28382232
Publikováno v:
Life Sciences. 88:1095-1101
Aims While β 2 -adrenoceptor (AR) agonists are useful bronchodilators, they also produce cardiac arrhythmias. These agents are not fully selective and also activate β 1 -AR, but the involvement of β 1 -AR and β 2 -AR in the observed pro-arrhythmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34f6fd234739d3ad500f66e274eadb6
https://doi.org/10.1016/j.lfs.2011.04.015
https://doi.org/10.1016/j.lfs.2011.04.015
Publikováno v:
European Journal of Pharmacology. 607:151-155
The effects of salbutamol on contractility and cAMP levels were investigated in rat right ventricular myocardium. Salbutamol (1-300 microM), produced a concentration-dependent positive inotropic effect which was not affected by ICI 118551 (50 nM), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfa6e4e59124f03ece26b8fec4dd7b5
https://doi.org/10.1016/j.ejphar.2009.02.029
https://doi.org/10.1016/j.ejphar.2009.02.029