Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jesús Garcia‐Foncillas"'
Autor:
Aiora Cenigaonandia‐Campillo, Ana Garcia‐Bautista, Anxo Rio‐Vilariño, Arancha Cebrian, Laura delPuerto, José Antonio Pellicer, José Antonio Gabaldón, Horacio Pérez‐Sánchez, Miguel Carmena‐Bargueño, Carolina Meroño, Javier Traba, María Jesús Fernandez‐Aceñero, Natalia Baños‐Herraiz, Lorena Mozas‐Vivar, Estrella Núñez‐Delicado, Jesús Garcia‐Foncillas, Óscar Aguilera
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2212-2233 (2024)
In pancreatic ductal adenocarcinoma (PDAC), metabolic rewiring and resistance to standard therapy are closely associated. PDAC cells show enormous requirements for glucose‐derived citrate, the first rate‐limiting metabolite in the synthesis of ne
Externí odkaz:
https://doaj.org/article/15680545600940349d1f3088fd3a5d0b
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 1, Pp 840-865 (2012)
Recent advances in the field of RNA research have provided compelling evidence implicating microRNA (miRNA) and long non-coding RNA molecules in many diverse and substantial biological processes, including transcriptional and post-transcriptional reg
Externí odkaz:
https://doaj.org/article/7b0ed8f37da84b478bccefe4bc1725b7
Akademický článek
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Autor:
Laura del Puerto-Nevado, María J. Fernández-Aceñero, Arancha Cebrián, Yuliia Fatych, Luis I. Díez-Valladares, Elia Pérez-Aguirre, Sofía de la Serna, Alejandra García-Botella, Javier Martínez-Useros, Jesús García-Foncillas, Pedro A. Mateos-Gómez
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDNA polymerase theta (POLQ) is a translesion synthesis polymerase essential for the repair of double strand breaks by the error-prone TMEJ (Theta Mediated End Joining) pathway. Although POLQ participates in maintaining genome stability, sev
Externí odkaz:
https://doaj.org/article/0b3c55f609be443fb31ae697dcffea83
Autor:
Shaomin Zou, Yizhi Huang, Ziqing Yang, Jieping Zhang, Manqi Meng, Yijing Zhang, Junyan Feng, Rui Sun, Weiyao Li, Wencong Wang, Jesús García‐Foncillas López, Lekun Fang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Background NOP2/Sun domain 2 (NSUN2) is one of the important RNA methyltransferases catalyzing 5‐methylcytosine (m5C) formation and participates in many critical bioprocesses. However, the roles and underlying molecular mechanisms of NSUN2
Externí odkaz:
https://doaj.org/article/26e23d0b2dc04d99b082fbce6001a3e9
Autor:
Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more c
Externí odkaz:
https://doaj.org/article/0c66d90901d244e6922dd1f9ea0a3f1f
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The immune system of people living with HIV (PLWH) is persistently exposed to antigens leading to systemic inflammation despite combination antiretroviral treatment (cART). This inflammatory milieu promotes T-cell activation and exhaustion. Furthermo
Externí odkaz:
https://doaj.org/article/a7b307119186420eac3802d288dc0ce9
Autor:
Carlos Lacalle-Gonzalez, Maria Florez-Cespedes, Lara Sanz-Criado, Michael Ochieng’ Otieno, Edurne Ramos-Muñoz, Maria Jesus Fernandez-Aceñero, Luis Ortega-Medina, Jesus Garcia-Foncillas, Javier Martinez-Useros
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2812 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm with very poor patient survival outcomes despite available treatments. There is an urgent need for new potential treatment options and novel biomarkers for these patients. Delta-like c
Externí odkaz:
https://doaj.org/article/2d55f38ea8944f848534712b13302ea6
Autor:
Carlos Lopez-Blazquez, Carlos Lacalle-Gonzalez, Lara Sanz-Criado, Michael Ochieng’ Otieno, Jesus Garcia-Foncillas, Javier Martinez-Useros
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14979 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating tumor type where a very high proportion of people diagnosed end up dying from cancer. Surgical resection is an option for only about 20% of patients, where the 5-year survival increase ranges f
Externí odkaz:
https://doaj.org/article/363884063a8f454183ce6248b045bae2
Autor:
Juan Manuel Corral, Laura del Puerto-Nevado, Mabel Cedeño, Anxo Río-Vilariño, Ignacio Mahillo-Fernández, Carlos Galeano, Natalia Baños, Jesús García-Foncillas, Manuel Dómine, Arancha Cebrián
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113987- (2022)
Introduction: small-cell lung cancer (SCLC) is one of the most lethal malignancies. Its management is complex due to the lack of biomarkers and limited therapies. Galectin-1 (Gal-1) plays a major role in cancer development and progression. The aim of
Externí odkaz:
https://doaj.org/article/3881d83dc0a745b8889a15884f4ca2fc