Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jesús García-Castillo"'
Autor:
Elena Martínez-Balsalobre, Jesús García-Castillo, Diana García-Moreno, Elena Naranjo-Sánchez, Miriam Fernández-Lajarín, María A. Blasco, Francisca Alcaraz-Pérez, Victoriano Mulero, María L. Cayuela
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Telomerase RNA (TERC) has a noncanonical function in myelopoiesis binding to a consensus DNA binding sequence and attracting RNA polymerase II (RNA Pol II), thus facilitating myeloid gene expression. The CR4/CR5 domain of TERC is known to pl
Externí odkaz:
https://doaj.org/article/b9be5c1113344b78b8c5918c5e096611
Autor:
Manuel Bernabé‐García, Elena Martínez‐Balsalobre, Diana García‐Moreno, Jesús García‐Castillo, Beatriz Revilla‐Nuin, Elena Blanco‐Alcaina, Victoriano Mulero, Francisca Alcaraz‐Pérez, María L. Cayuela
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1818-1834 (2021)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described. In this study, we report that
Externí odkaz:
https://doaj.org/article/310687909ba642c2bc2405940c482ed2
Autor:
Santiago Nahuel Villegas, Rita Gombos, Lucia García-López, Irene Gutiérrez-Pérez, Jesús García-Castillo, Diana Marcela Vallejo, Vanina Gabriela Da Ros, Esther Ballesta-Illán, József Mihály, Maria Dominguez
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2541-2549 (2018)
Summary: The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of aggressive cancers. Elucidating how the PI3K/Akt pathway facilitates tumorigenesis by other oncogenes may offer opportunities to develop drugs with fewe
Externí odkaz:
https://doaj.org/article/e30be5c228aa4cf4934cb3c6273cb520
Autor:
Jesús García-Castillo, Victoriano Mulero, Francisca Alcaraz-Pérez, Elena Martínez-Balsalobre, David Hernández-Silva, Monique Anchelin-Flageul, Maria Caterina Mione, María L. Cayuela
Telomeres are essential for chromosome protection and genomic stability, and telomerase function is critical to organ homeostasis. Zebrafish has become a useful vertebrate model for understanding the cellular and molecular mechanisms of regeneration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df202dc6c7dc85ad390764347f4feeae
https://doi.org/10.1101/2021.11.15.468592
https://doi.org/10.1101/2021.11.15.468592
Autor:
Virginia C Rodriguez-Cortez, Francisca Alcaraz-Pérez, Leonard I. Zon, Isaac Adatto, Miriam Fernandez-Lajarín, Diana García-Moreno, Victoriano Mulero, María L. Cayuela, Suneet Agarwal, Clara Bueno, Manuel Bernabé-García, Elena Martínez-Balsalobre, Marlies P. Rossmann, Ana B. Pérez-Oliva, Pablo Menendez, Jesús García-Castillo
Publikováno v:
Proc Natl Acad Sci U S A
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition syndrome caused by mutations in telomerase or telomeric proteins. Here, we report that zebrafish telomerase RNA (terc) binds to specific DNA sequences of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a1cfeed783a66cdec2bd5950a55f25
https://doi.org/10.1073/pnas.2015528118
https://doi.org/10.1073/pnas.2015528118
Autor:
Francisca Alcaraz-Pérez, Victoriano Mulero, Elena Blanco-Alcaina, Jesús García-Castillo, Manuel Bernabé-García, Elena Martínez-Balsalobre, Beatriz Revilla-Nuin, Diana García-Moreno, María L. Cayuela
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 7, Pp 1818-1834 (2021)
Molecular Oncology, Vol 15, Iss 7, Pp 1818-1834 (2021)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described. In this study, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb69f40644c2c6c170f6fd286a61eb1
https://doi.org/10.1002/1878-0261.12943
https://doi.org/10.1002/1878-0261.12943
Autor:
Manuel Bernabé-García, Elena Martínez-Balsalobre, Beatriz Revilla-Nuin, Victoriano Mulero, Francisca Alcaraz-Pérez, Elena Blanco-Alcaina, María L. Cayuela, Diana García-Moreno, Jesús García-Castillo
The classical activity of telomerase (TERT) is to maintain telomere homeostasis, ensuring chromosome stability and cellular proliferation. However, increasing evidences of telomere-independent human TERT functions have been lastly obtained. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28787b3b458f314e7c5771a81254df37
Autor:
Jesús García-Castillo, Vanina Gabriela Da Ros, Santiago Nahuel Villegas, Diana M. Vallejo, Esther Ballesta-Illan, József Mihály, Maria Dominguez, Lucia García-López, Rita Gombos, Irene Gutierrez-Perez
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell Reports, Vol 22, Iss 10, Pp 2541-2549 (2018)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell Reports, Vol 22, Iss 10, Pp 2541-2549 (2018)
The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of aggressive cancers. Elucidating how the PI3K/Akt pathway facilitates tumorigenesis by other oncogenes may offer opportunities to develop drugs with fewer side ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0b145281983eb48c56791f8bf30f39
http://linkinghub.elsevier.com/retrieve/pii/S2211124718302304
http://linkinghub.elsevier.com/retrieve/pii/S2211124718302304
Autor:
Kim Pedersen, Nuria Colomé, Joan Josep Bech-Serra, Pier-Davide Angelini, Jesús García-Castillo, Joaquín Arribas, Francesc Canals, Josep Lluís Parra-Palau, Matthew Paul Cunningham, José Baselga
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
A group of breast cancer patients with a higher probability of developing metastasis expresses a series of carboxyl-terminal fragments (CTFs) of the tyrosine kinase receptor HER2. One of these fragments, 611-CTF, is a hyperactive form of HER2 that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9578194282990a8dfdbcd05910229987
https://doi.org/10.1074/jbc.m109.001982
https://doi.org/10.1074/jbc.m109.001982
Publikováno v:
Immunogenetics. 54:200-207
The tumor necrosis factor α (TNF α) gene from the marine fish, gilthead seabream (Sparus aurata L.), has been isolated by RT-PCR using degenerate primers designed against vertebrate TNF α conserved motifs and subsequent rapid amplification of cDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813a5ee26f755b0aefd21c836091123d
https://doi.org/10.1007/s00251-002-0451-y
https://doi.org/10.1007/s00251-002-0451-y