Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jesús Gómez-Escudero"'
Autor:
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/33e6176c6d6a4fc595fff02b19cc1f2f
Autor:
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown. We show tha
Externí odkaz:
https://doaj.org/article/327b0c1e155a4263840ab94acda7cb38
Autor:
Kairbaan Hodivala-Dilke, Pedro R. Cutillas, Cyrill Géraud, Ping-Pui Wong, Victoria Sanz-Moreno, Dieter Saur, Peter B. Vermeulen, Ya-Ming Meng, Christof Dormann, Céline Weller, Frances M. Richards, Jesús Gómez-Escudero, Rebecca J.G. Drake, Vinothini Rajeeve, Emma Newport, Laura Wisniewski, Oscar Maiques, Beatriz de Luxán-Delgado, Louise E. Reynolds, Marina Roy-Luzarraga
Supplementary Data from Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6fbefb5bd893c63c43ec853b8f0ac9
https://doi.org/10.1158/0008-5472.22430214.v1
https://doi.org/10.1158/0008-5472.22430214.v1
Autor:
Kairbaan Hodivala-Dilke, Pedro R. Cutillas, Cyrill Géraud, Ping-Pui Wong, Victoria Sanz-Moreno, Dieter Saur, Peter B. Vermeulen, Ya-Ming Meng, Christof Dormann, Céline Weller, Frances M. Richards, Jesús Gómez-Escudero, Rebecca J.G. Drake, Vinothini Rajeeve, Emma Newport, Laura Wisniewski, Oscar Maiques, Beatriz de Luxán-Delgado, Louise E. Reynolds, Marina Roy-Luzarraga
Despite substantial advances in the treatment of solid cancers, resistance to therapy remains a major obstacle to prolonged progression-free survival. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, with a high level of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dda4b98719c7b41db9c381a53b02befb
https://doi.org/10.1158/0008-5472.c.6513567.v1
https://doi.org/10.1158/0008-5472.c.6513567.v1
Autor:
Kairbaan Hodivala-Dilke, Pedro R. Cutillas, Cyrill Géraud, Ping-Pui Wong, Victoria Sanz-Moreno, Dieter Saur, Peter B. Vermeulen, Ya-Ming Meng, Christof Dormann, Céline Weller, Frances M. Richards, Jesús Gómez-Escudero, Rebecca J.G. Drake, Vinothini Rajeeve, Emma Newport, Laura Wisniewski, Oscar Maiques, Beatriz de Luxán-Delgado, Louise E. Reynolds, Marina Roy-Luzarraga
Supplementary Figure from Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175e0f6375823c8293a0ca1880258164
https://doi.org/10.1158/0008-5472.22430202.v1
https://doi.org/10.1158/0008-5472.22430202.v1
Autor:
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxán-Delgado, Oscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J.G. Drake, Jesús Gómez-Escudero, Frances M. Richards, Céline Weller, Christof Dormann, Ya-Ming Meng, Peter B. Vermeulen, Dieter Saur, Victoria Sanz-Moreno, Ping-Pui Wong, Cyrill Géraud, Pedro R. Cutillas, Kairbaan Hodivala-Dilke
Publikováno v:
Cancer Research. 82:1909-1925
Despite substantial advances in the treatment of solid cancers, resistance to therapy remains a major obstacle to prolonged progression-free survival. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, with a high level of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae75c56f3ed1498303615cd01969fa15
https://doi.org/10.1158/0008-5472.can-20-3807
https://doi.org/10.1158/0008-5472.can-20-3807
Autor:
Gabriela D'Amico, Isabelle Fernandez, Jesús Gómez-Escudero, Hyojin Kim, Eleni Maniati, Muhammad Syahmi Azman, Faraz K. Mardakheh, Bryan Serrels, Alan Serrels, Maddy Parsons, Anthony Squire, Graeme M. Birdsey, Anna M. Randi, Alfonso Bolado-Carrancio, Rathi Gangeswaran, Louise E. Reynolds, Natalia Bodrug, Yaohe Wang, Jun Wang, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
D'amico, G, Fernandez, I, Gómez-escudero, J, Kim, H, Maniati, E, Azman, M S, Mardakheh, F K, Serrels, B, Serrels, A, Parsons, M, Squire, A, Birdsey, G M, Randi, A M, Bolado-carrancio, A, Gangeswaran, R, Reynolds, L E, Bodrug, N, Wang, Y, Wang, J, Meier, P & Hodivala-dilke, K M 2022, ' ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning ', Development, vol. 149, no. 13, dev200528 . https://doi.org/10.1242/dev.200528
Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell (EC) dynamics and developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8d1df014fcaf9eb06716278dbabc54
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85134426448
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85134426448
Autor:
José Antonio Enríquez, Peter Carmeliet, Alicia G. Arroyo, Jaime Millán, Katie Bentley, Rebeca Acín-Pérez, Diego García-Weber, Jesús Gómez-Escudero, Cristina Clemente
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
18 p.-7 fig.
Angiogenesis, the formation of new blood vessels from pre-existing ones, occurs in pathophysiological contexts such as wound healing, cancer, and chronic inflammatory disease. During sprouting angiogenesis, endothelial tip and stalk
Angiogenesis, the formation of new blood vessels from pre-existing ones, occurs in pathophysiological contexts such as wound healing, cancer, and chronic inflammatory disease. During sprouting angiogenesis, endothelial tip and stalk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7855808e937c76f9a91e4116b65fe1d
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396701
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396701
Autor:
Enrique Calvo, Mara Martín-Alonso, Stephen J. Weiss, Fernando Martínez, Menno J. Oudhoff, Alicia G. Arroyo, Ángel Colmenar, M. Victoria Hernández-Riquer, Emilio Camafeita, Jesús Gómez-Escudero, Vanessa Moreno, Tamar Feinberg
Publikováno v:
Journal of Cell Science
Cadherin-based intercellular adhesions are essential players in epithelial homeostasis, but their dynamic regulation during tissue morphogenesis and remodeling remain largely undefined. Herein, we characterize an unexpected role for the membrane-anch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edd64b4fe6145442686835b3b3715d3
https://pubmed.ncbi.nlm.nih.gov/29061881
https://pubmed.ncbi.nlm.nih.gov/29061881
Autor:
Domagoj Vugic, Isaac Dumoulin, Charlotte Martin, Anna Minello, Lucia Alvaro-Aranda, Jesus Gomez-Escudero, Rady Chaaban, Rana Lebdy, Catharina von Nicolai, Virginie Boucherit, Cyril Ribeyre, Angelos Constantinou, Aura Carreira
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Here the authors demonstrate that the dsDNA binding function at the N-terminus of BRCA2 prevents nucleotide depletion-dependent replicative ssDNA gaps but not those induced by PARP inhibition. This function is impaired in breast-cancer variants affec
Externí odkaz:
https://doaj.org/article/da096cea1a02470f8a2851555746cfb7