IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

Autor: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado, José L. Pablos

Publikováno v: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-12 (2020)

Abstract Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target

Externí odkaz: https://doaj.org/article/d966f2637fe742f6aedba0c75a9ebd6b

Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice

Autor: Elena Vega-Martín, Marta Gil-Ortega, Raquel González-Blázquez, Sara Benedito, Jesús Fernández-Felipe, Mariano Ruiz-Gayo, Nuria del Olmo, Julie A. Chowen, Laura M. Frago, Beatriz Somoza, María S. Fernández-Alfonso

Publikováno v: Nutrients, Vol 13, Iss 3, p 1003 (2021)

Vegetable oils such as palm oil (enriched in saturated fatty acids, SFA) and high-oleic-acid sunflower oil (HOSO, containing mainly monounsaturated fatty acids, MUFA) have emerged as the most common replacements for trans-fats in the food industry. T

Externí odkaz: https://doaj.org/article/7d07827153ee48ad83f4fce9c6e86bed

Regional specific effect of saturated vs unsaturated fat on leptin receptor signalling in mice brain areas regulating feeding

Autor: Jesús Fernández-Felipe, Lucía L. López, Victoria Cano, Enrique Sánchez-Hita, A. Belén Sanz, Julie A. Chowen, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merino

Publikováno v: Neuroscience letters. 793

Leptin receptors (LepR) are expressed in brain areas controlling food intake homeostasis, such as the hypothalamus, the hippocampus and the prefrontal cortex. In a previous study we reported that long-term intake of saturated and monounsaturated fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce1576ad2266165faa56cf37935dfbb
https://pubmed.ncbi.nlm.nih.gov/36481371

Butyric Acid Precursor Tributyrin Modulates Hippocampal Synaptic Plasticity and Prevents Spatial Memory Deficits: Role of PPARγ and AMPK

Autor: Ana Belén Sanz-Martos, Jesús Fernández-Felipe, Beatriz Merino, Victoria Cano, Mariano Ruiz-Gayo, Nuria Del Olmo

Publikováno v: The international journal of neuropsychopharmacology. 25(6)

Background Short chain fatty acids (SCFA), such as butyric acid (BA), derived from the intestinal fermentation of dietary fiber and contained in dairy products, are gaining interest in relation to their possible beneficial effects on neuropsychologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe27ce3ad3eac47033abc3f846ceee8f
https://pubmed.ncbi.nlm.nih.gov/35152284

Il6/Sil6R Regulates Tnfα-Inflammatory Response In Synovial Fibroblasts Through Modulation of Transcriptional and Post-Transcriptional Mechanisms

Autor: Marina Romero, Yolanda Ruano, José L. Pablos, Francisco J. Blanco, Alicia Usategui, Cristina Municio, Alvaro Valin, Gabriel Criado, Jesús Fernández-Felipe, Juan D. Cañete, Manuel J. Del Rey

Publikováno v: BMC Molecular and Cell Biology
RUC. Repositorio da Universidade da Coruña
instname
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-12 (2020)
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)

Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ff462129737279ed2447ac4a13bdce
https://doi.org/10.21203/rs.3.rs-32228/v1