Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Jesús F. Aparicio"'
Autor:
Cláudia M. Vicente, Tamara D. Payero, Antonio Rodríguez-García, Eva G. Barreales, Antonio de Pedro, Fernando Santos-Beneit, Jesús F. Aparicio
Publikováno v:
Antibiotics, Vol 11, Iss 8, p 994 (2022)
PAS-LuxR transcriptional regulators are conserved proteins governing polyene antifungal biosynthesis. PteF is the regulator of filipin biosynthesis from Streptomyces avermitilis. Its mutation drastically abates filipin, but also oligomycin production
Externí odkaz:
https://doaj.org/article/573086844cdd4df2bcd46469bf478950
Autor:
Álvaro Mourenza, Blanca Lorente-Torres, Elena Durante, Jesús Llano-Verdeja, Jesús F. Aparicio, Arsenio Fernández-López, José A. Gil, Luis M. Mateos, Michal Letek
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 356 (2022)
The development of RNA-based anti-infectives has gained interest with the successful application of mRNA-based vaccines. Small RNAs are molecules of RNA of
Externí odkaz:
https://doaj.org/article/ed9d1741fa8848028250b0a558dfae2f
Autor:
Yolanda Martínez-Burgo, Javier Santos-Aberturas, Antonio Rodríguez-García, Eva G. Barreales, José Rubén Tormo, Andrew W. Truman, Fernando Reyes, Jesús F. Aparicio, Paloma Liras
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Expression of non-native transcriptional activators may be a powerful general method to activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose archetype is PimM, activate the biosynthesis of polyene macrolide antifungals and
Externí odkaz:
https://doaj.org/article/d6b30479f65e4da7b83c3debf9d3b47b
Autor:
Eva G. Barreales, Ángel Rumbero, Tamara D. Payero, Antonio de Pedro, Ester Jambrina, Jesús F. Aparicio
Publikováno v:
Antibiotics, Vol 9, Iss 7, p 413 (2020)
The rise in the number of immunocompromised patients has led to an increased incidence of fungal infections, with high rates of morbidity and mortality. Furthermore, misuse of antifungals has boosted the number of resistant strains to these agents; t
Externí odkaz:
https://doaj.org/article/e38ccab5e36940499a947c50e0d393fb
Autor:
Cláudia M. Vicente, Tamara D. Payero, Antonio Rodríguez-García, Eva G. Barreales, Antonio de Pedro, Fernando Santos-Beneit, Jesús F. Aparicio
PAS-LuxR transcriptional regulators are highly conserved enzymes governing polyene macrolide antifungal biosynthesis. PteF is one of such regulators, situated in the polyene macrolide filipin gene cluster from Streptomyces avermitilis. Its mutation l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8e7238d261c07869ddad835f8ba068c
https://doi.org/10.1101/2022.06.10.495441
https://doi.org/10.1101/2022.06.10.495441
Autor:
Jesús F. Aparicio, Eva G. Barreales
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613573
Polyene antibiotics are macrolide antifungal compounds obtained by fermentation of producer Streptomyces strains. Here we describe commonly used methods for polyene production, detection, and their subsequent extraction and purification. While bioass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89370e9a95964a7beaac078a5be925bd
https://doi.org/10.1007/978-1-0716-1358-0_19
https://doi.org/10.1007/978-1-0716-1358-0_19
Publikováno v:
Applied and Environmental Microbiology
Streptomyces GBLs are important signaling molecules that trigger antibiotic production in a quorum sensing-dependent manner. We have characterized the GBL system from S. filipinensis, finding that two key players of this system, the GBL receptor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c3de2909aadf8070666ab6d622057
https://doi.org/10.1128/aem.00443-20
https://doi.org/10.1128/aem.00443-20
Autor:
Ester Jambrina, Angel Rumbero, Antonio de Pedro, Eva G. Barreales, Jesús F. Aparicio, Tamara D. Payero
Publikováno v:
Antibiotics, Vol 9, Iss 413, p 413 (2020)
Antibiotics
Volume 9
Issue 7
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Antibiotics
Volume 9
Issue 7
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
The rise in the number of immunocompromised patients has led to an increased incidence of fungal infections, with high rates of morbidity and mortality. Furthermore, misuse of antifungals has boosted the number of resistant strains to these agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05b4b5ed44442226e05e0000675289c
https://www.mdpi.com/2079-6382/9/7/413
https://www.mdpi.com/2079-6382/9/7/413
Autor:
Yolanda, Martínez-Burgo, Javier, Santos-Aberturas, Antonio, Rodríguez-García, Eva G, Barreales, José Rubén, Tormo, Andrew W, Truman, Fernando, Reyes, Jesús F, Aparicio, Paloma, Liras
Publikováno v:
Frontiers in Microbiology
Expression of non-native transcriptional activators may be a powerful general method to activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose archetype is PimM, activate the biosynthesis of polyene macrolide antifungals and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c92ff08a491a8c5e9e852966ede83a3
https://pubmed.ncbi.nlm.nih.gov/30984130
https://pubmed.ncbi.nlm.nih.gov/30984130
Autor:
Javier Santos-Aberturas, Jesús F. Aparicio, Antonio de Pedro, Cláudia M. Vicente, Eva G. Barreales
Publikováno v:
Applied and Environmental Microbiology
Applied and Environmental Microbiology, American Society for Microbiology, 2018, 84 (10), ⟨10.1128/AEM.00246-18⟩
Applied and Environmental Microbiology, American Society for Microbiology, 2018, 84 (10), ⟨10.1128/AEM.00246-18⟩
The biosynthesis of small-size polyene macrolides is ultimately controlled by a couple of transcriptional regulators that act in a hierarchical way. A Streptomyces antibiotic regulatory protein–large ATP-binding regulator of the LuxR family (SARP-L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e47194deedb74db902a4f3c34976f6
https://pubmed.ncbi.nlm.nih.gov/29500267
https://pubmed.ncbi.nlm.nih.gov/29500267