Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jesús Ángel de la Fuente"'
Autor:
Sonia Moliner-Cubel, Jesús Ángel de la Fuente, Maria G. Gomez-Lorenzo, Noemí Bahamontes-Rosa, Jose Luis Lavandera, Ruben Gonzalez Del Rio, María Martínez-Hoyos, Alfonso Mendoza-Losana, Carolina Ródenas, Jose F. Garcia-Bustos, Ane Rodríguez-Alejandre
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 295-303 (2018)
International Journal for Parasitology: Drugs and Drug Resistance
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
International Journal for Parasitology: Drugs and Drug Resistance
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Phenotypic screening has produced most of the new chemical entities currently in clinical development for malaria, plus many lead compounds active against Plasmodium falciparum asexual stages. However, lack of knowledge about the mode of action of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fa76b73e95e10266a10422f53f7a89
http://www.sciencedirect.com/science/article/pii/S2211320717301203
http://www.sciencedirect.com/science/article/pii/S2211320717301203
Autor:
Francesc X. Ruiz, Michael Betz, Felix Terwesten, Jesús Ángel de la Fuente, Alberto Podjarny, Alexandra Cousido-Siah, Xavier Parés, Sonia Manzanaro, Sergio Porté, Gerhard Klebe, María Jesús Martín, Angel R. de Lera, Jaume Farrés, Andre Mitschler
Publikováno v:
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Aldo-keto reductases (AKRs) are mostly monomeric enzymes which fold into a highly conserved (α/β)8barrel, while their substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable exter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ff6d8cb5a0cec41a9c441acfd8e49a
https://doi.org/10.1107/s1399004713033452
https://doi.org/10.1107/s1399004713033452
Autor:
Stephen P. Watson, Adelheid Roth, Anna Sava, Greg J. Osborne, David John Nash, Paloma Perez, Ben Powney, Corrado Corti, Magalie Rocheville, Paul W. Smith, Clive Leslie Branch, Federica Bianchi, Pier D’Alessandro, Emma Koppe, Maite de los Frailes, Jesús Ángel de la Fuente, Annarosa Ugolini, Dino Montanari, Stephen L. Garland
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:759-762
The optimisation of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5af6d59aa839fa93266ba75cb6cf3fc
https://doi.org/10.1016/j.bmcl.2009.11.032
https://doi.org/10.1016/j.bmcl.2009.11.032
Autor:
Alberto Podjarny, Gerhard Klebe, C. Rechlin, Sergio Porté, Andre Mitschler, Xavier Parés, Alexandra Cousido-Siah, Jesús Ángel de la Fuente, Isidro Crespo, María Jesús Martín, Angel R. de Lera, Marta Domínguez, F.X. Ruiz, Jaume Farrés
Publikováno v:
ChemMedChem. 10(12)
The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2-(3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e330b9f8ce3603cb50fc0b2411b3f43
https://pubmed.ncbi.nlm.nih.gov/26549844
https://pubmed.ncbi.nlm.nih.gov/26549844
Autor:
Jesús Ángel de la Fuente, Sonia Manzanaro, Santos Luengo, Teresa García De Quesada, Isabel Reymundo, María Jesús Martín, Federico Gago
Publikováno v:
Journal of Medicinal Chemistry. 46:5208-5221
Aldose reductase (ALR2) has been implicated in the etiology of diabetic complications, including blindness. Because of the limited number of currently available drugs for the prevention of these long-term complications, the discovery of new ALR2 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e30529e57a6ecd9979d1d171061ef0
https://doi.org/10.1021/jm030957n
https://doi.org/10.1021/jm030957n
Autor:
David G. Tew, Alfonso Rivera-Sagredo, Paloma Perez, Cheryl A. Janson, Nestor O. Concha, Martin Gilpin, Juan A. Hueso-Rodríguez, Michael Rees, John H. Bateson, Jesús Ángel de la Fuente, Helen F. Boyd, Niconovich Nancy, Stewart C. Pearson, Christy Cheever, David J. Payne, E. Diez, Stephen Rittenhouse
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:1880-1886
Metallo-β-lactamases provide bacteria with an efficient and effective way of mediating resistance to β-lactam-based antibacterial agents. More significantly, they confer resistance to carbapenems. Therefore, if metallo-β-lactamases increase in pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aa937c16cee0ca888b0a557de1cdef
https://doi.org/10.1128/aac.46.6.1880-1886.2002
https://doi.org/10.1128/aac.46.6.1880-1886.2002
Autor:
Librada M. Cañedo, Jesús Ángel de la Fuente, Carlos Jiménez, Ricardo Riguera, María J. Ferreiro, Cristina Gesto
Publikováno v:
Tetrahedron Letters. 40:6841-6844
Agrochelin (1), a new cytotoxic thiazole alkaloid, has been isolated from the fermentation broth of a marine unicellular bacterium belonging to genus Agrobacterium. Its structure was determined from spectral data and chemical transformations. Agroche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb0440e45a5c7a065198ea5a60a16773
https://doi.org/10.1016/s0040-4039(99)01377-5
https://doi.org/10.1016/s0040-4039(99)01377-5
Autor:
Santiago Álvarez García, Alfonso Fernández Mateos, Jesús Ángel de la Fuente, Amador Menéndez, Sue S. Cross, Juan J. Marugan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1471-1474
Here we report a novel non-nucleoside compound, PM-92131(+), with in vitro anti-HIV-1 activity. This product was synthesized as a pure enantiomer via diastereomeric ester formation and selective crystallisation and its absolute stereochemistry was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20f80194c53c5e0926b866f092e2f460
https://doi.org/10.1016/0960-894x(95)00260-z
https://doi.org/10.1016/0960-894x(95)00260-z
Autor:
María J. Ferreiro, Jesús Ángel de la Fuente, Ricardo Riguera, Carlos Jiménez, Librada M. Cañedo, Cristina Gesto
Publikováno v:
ChemInform. 30
Agrochelin (1), a new cytotoxic thiazole alkaloid, has been isolated from the fermentation broth of a marine unicellular bacterium belonging to genus Agrobacterium. Its structure was determined from spectral data and chemical transformations. Agroche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d06d88531cf8cd57eaf08c7d0c4deb7
https://doi.org/10.1002/chin.199946206
https://doi.org/10.1002/chin.199946206
Autor:
Marta Domínguez, Jesús Ángel de la Fuente, Alberto Podjarny, Alexandra Cousido-Siah, María Jesús Martín, Angel R. de Lera, F.X. Ruiz, C. Rechlin, Jaume Farrés, Gerhard Klebe, Isidro Crespo, Andre Mitschler, Sergio Porté, Xavier Parés
Publikováno v:
ChemMedChem. 10:1941-1941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06125e60e7f2d57974c11212a79d71af
https://doi.org/10.1002/cmdc.201500528
https://doi.org/10.1002/cmdc.201500528