Výsledky vyhledávání - "Jesús, Ogando"

Akademický článek

PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes

Autor: Jesús Ogando, María Eugenia Sáez, Javier Santos, Cristina Nuevo-Tapioles, Marta Gut, Anna Esteve-Codina, Simon Heath, Antonio González-Pérez, José M. Cuezva, Rosa Ana Lacalle, Santos Mañes

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)

Abstract Background Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer treatment, yet the inhib

Externí odkaz: https://doaj.org/article/bf07bf307d7e439992d5b6c5761a4ede

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A flow cytometry-based method to screen for modulators of tumor-specific T cell cytotoxicity

Autor: Javier, Santos, Jesús, Ogando, Rosa Ana, Lacalle, Santos, Mañes

Publikováno v: Methods in enzymology. 631

Cancer immunotherapy relies on the ability of immune cells to kill malignant cells. The cytotoxic T lymphocyte (CTL) response is perhaps the functional measure that best reflects cell-mediated immunity against cancer. Straightforward methods that fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e33eab4f4c89749fccf2ae3f41332d4c
https://pubmed.ncbi.nlm.nih.gov/31948564

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A flow cytometry-based method to screen for modulators of tumor-specific T cell cytotoxicity

Autor: Javier Santos, Rosa Ana Lacalle, Jesús Ogando, Santos Mañes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f6fe3b2a6b3e93f6221ca63ebfe5c91
https://doi.org/10.1016/bs.mie.2019.02.040

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PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8

Autor: Jesús, Ogando, María Eugenia, Sáez, Javier, Santos, Cristina, Nuevo-Tapioles, Marta, Gut, Anna, Esteve-Codina, Simon, Heath, Antonio, González-Pérez, José M, Cuezva, Rosa Ana, Lacalle, Santos, Mañes

Publikováno v: Journal for Immunotherapy of Cancer

Background Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer treatment, yet the inhibitory sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e6625e9a9a5804d8652cf5aa564f589e
https://pubmed.ncbi.nlm.nih.gov/31196176

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Diacylglycerol kinase α inactivation is an integral component of the costimulatory pathway that amplifies TCR signals

Autor: Jesús Ogando, Javier Arranz-Nicolás, Santos Mañes, Raquel Arcos-Pérez, Daniel Meraviglia-Crivelli, Denise Soutar, Antonia Ávila-Flores, Isabel Mérida

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The arsenal of cancer therapies has evolved to target T lymphocytes and restore their capacity to destroy tumor cells. T cells rely on diacylglycerol (DAG) to carry out their functions. DAG availability and signaling are regulated by the enzymes diac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2973a1df850896a7cf9895d10f9b950
https://pubmed.ncbi.nlm.nih.gov/29572701

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Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients

Autor: María Carmen Bellver Moreno, Jesús Ogando, Sara Escudero, Ildefonso Cases, Manuel Tardaguila, Juan D. Cañete, María J. García-León, Dannys Jorge Martinez-Herrera, María L. Toribio, Lorena de la Fuente, Santos Mañes, Alberto Pascual-Montano, Alicia Usategui, Andrea Díaz-Alderete, José L. Pablos, Vanessa Miranda-Ramos

Publikováno v: Scientific Reports
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Digital.CSIC. Repositorio Institucional del CSIC
instname
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)

Evidence links aryl hydrocarbon receptor (AHR) activation to rheumatoid arthritis (RA) pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory cytokine expression in macrophages, pivotal cells in RA aetiopathogenesis, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd598d2a5133dcff092c485ca9e66a5

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Involvement of lipid droplets in hepatic responses to lipopolysaccharide treatment in mice

Autor: Maitane Nuñez-Garcia, Jesús Ogando, Begoña Ochoa, Patricia Aspichueta, Olatz Fresnedo, Yuri Rueda, Lino Arisqueta, Itsaso Garcia-Arcos

Publikováno v: Biochimica et biophysica acta. 1831(8)

Infection and inflammation induce important changes in lipid metabolism, which result in increased free fatty acids and triacylglycerol in plasma and altered high density lipoprotein (HDL) metabolism. Our aim was to elucidate whether hepatic lipid dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae679c06c45f28bd01811cfcdf97fdd
https://pubmed.ncbi.nlm.nih.gov/23665317

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