Výsledky vyhledávání - "Jerzy Vetulani"

Fear memory-induced alterations in the mRNA expression of G proteins in the mouse brain and the impact of immediate posttraining treatment with morphine

Autor: Irena Nalepa, Katarzyna Rafa-Zabłocka, Agnieszka Zelek-Molik, Jerzy Vetulani, Adam Roman, Clelia Rossi-Arnaud, Marco Costanzi, Vincenzo Cestari, Grzegorz Kreiner

Publikováno v: Progress in neuro-psychopharmacologybiological psychiatry. 93

Disturbances in fear-evoked signal transduction in the hippocampus (HP), the nuclei of the amygdala (AMY), and the prefrontal cortex (PFC) underlie anxiety-related disorders. However, the molecular mechanisms underlying these effects remain elusive.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd22f894b599da667ff3625a74ea0248
https://pubmed.ncbi.nlm.nih.gov/30953677

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Early maternal separation: a rodent model of depression and a prevailing human condition

Autor: Jerzy Vetulani

Publikováno v: Pharmacological Reports. 65:1451-1461

The early life of most mammals is spent in close contact with the mother, and for the neonate, early maternal separation is a traumatic event that, depending on various conditions, may shape its behavioral and neurochemical phenotype in adulthood. St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad93b2295064cb417ab283eb7c8dab92
https://doi.org/10.1016/s1734-1140(13)71505-6

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3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity

Autor: Jerzy Vetulani, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk, Krystyna Ossowska

Publikováno v: European Journal of Pharmacology. 599:32-35

3-Methoxytyramine (3-MT), an extraneuronal metabolite of dopamine, present in the synaptic cleft at a very low amount (low nanomolar range), comparable to dopamine concentration, is generally regarded as a biologically inactive compound. We have show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b754b1adcfd8b7fbc24db5fb80d88d52
https://doi.org/10.1016/j.ejphar.2008.09.033

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An endogenous neuroprotectant substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), prevents the behavioral and neurochemical effects of cocaine reinstatement in drug-dependent rats

Autor: Jerzy Vetulani, Małgorzata Filip, Edmund Przegaliński, Lucyna Antkiewicz-Michaluk, Irena Romańska, Jerzy Michaluk

Publikováno v: Journal of Neural Transmission. 114:307-317

Drug abuse disorder is induced by a variety of substances and results from their interaction with the brain reward system. It is characterized by a high frequency of relapse, usually associated with to craving. In this study we investigated the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9e32ce3917abe22cf2730c3381c988
https://doi.org/10.1007/s00702-006-0546-y

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The mechanism of 1,2,3,4-tetrahydroisoquinolines neuroprotection: the importance of free radicals scavenging properties and inhibition of glutamate-induced excitotoxicity

Autor: Elzbieta Salinska, Elzbieta Zieminska, Jerzy Vetulani, Jerzy W. Lazarewicz, Krystyna Gołembiowska, Małgorzata Kajta, Antoni Patsenka, A. Wasik, Lucyna Antkiewicz-Michaluk

Publikováno v: Journal of Neurochemistry. 97:846-856

1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), unlike several other tetrahydroisoquinolines, displays neuroprotective properties. To elucidate this action we compared the effects of 1MeTIQ with 1,2,3,4-tetrahydroisoquinoline (TIQ), a compound shar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48ccd912ca272493f49a0406ef719e01
https://doi.org/10.1111/j.1471-4159.2006.03756.x

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Carane derivative stereoisomers of different local anaesthetic and antiplatelet activity similarly potentiate forskolin-stimulated cyclic AMP response and bind to β-adrenoceptors in the rat brain cortex

Autor: Jerzy Vetulani, Tadeusz Librowski, Irena Nalepa

Publikováno v: Journal of Pharmacy and Pharmacology. 56:1429-1434

A carane derivative, KP-23 [RS](–)-4-(2-hydroxy-3)N-isopropylamino)-propoxyimino)-cis-carane, was earlier described as a potential local anaesthetic and antiplatelet agent, and the following studies revealed that its R and S stereoisomers, KP-23R a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5120caf68e9338db790959c31873352
https://doi.org/10.1211/0022357044742

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Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone

Autor: Jadwiga Wardas, Jerzy Vetulani, Lucyna Antkiewicz-Michaluk, Andrzej J. Bojarski, Jerzy Michaluk, Irena Romańska

Publikováno v: The International Journal of Neuropsychopharmacology. 7:155-163

The aim of this paper was to investigate whether rotenone, a pesticide causing experimental parkinsonism, causes direct damage to dopaminergic structure when injected intracerebrally and whether this action may be prevented by peripheral administrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923b32aac5eff8838db4a6d296b88e48
https://doi.org/10.1017/s1461145703004036

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1-Methyl-1,2,3,4-tetrahydroisoquinoline protects against rotenone-induced mortality and biochemical changes in rat brain

Autor: Jerzy Michaluk, Irena Romańska, Jerzy Vetulani, Lucyna Antkiewicz-Michaluk, Andrzej J. Bojarski, Beata Karolewicz

Publikováno v: European Journal of Pharmacology. 466:263-269

The effect of single and multiple administration of the neurotoxic pesticide, rotenone, and the potentially neuroprotective compound, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), on the concentration of dopamine and its metabolites (homovanillic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a56d5c7eb925de412ecf7800fc9ee17
https://doi.org/10.1016/s0014-2999(03)01565-6

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A possible physiological role for cerebral tetrahydroisoquinolines

Autor: Irena Nalepa, Mario Sansone, Lucyna Antkiewicz-Michaluk, Jerzy Vetulani

Publikováno v: Neurotoxicity Research. 5:147-155

Tetrahydroisoquinolines present in the mammalian brain, 1,2,3,4-tetrahydroisoquinoline (TIQ) and salsolinol, suspected to cause neurodegeneration leading to Parkinson's disease, were investigated to find their possible physiological role. To this aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da86af2de5afbd1c8164111327a972b
https://doi.org/10.1007/bf03033379

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Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties

Autor: Shigeru Ohta, Jerzy Vetulani, Lucyna Antkiewicz-Michaluk, Jerzy Michaluk, Irena Romańska, Elbieta Lorenc-Koci, Maria J. Mokrosz

Publikováno v: Journal of Neurochemistry. 78:100-108

The effect of single and multiple 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) and 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) administration on concentrations of dopamine and its metabolites: homovanillic acid (HVA) and 3,4-dihydroxyphenyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58c0b290944d0fcecb06277c6b6f74db
https://doi.org/10.1046/j.1471-4159.2001.00391.x

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