Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jerzy Trojnar"'
Autor:
Jerzy Ciarkowski, Magdalena J. Ślusarz, Rafał Ślusarz, Robert Meadows, Artur Giełdoń, Jerzy Trojnar
Publikováno v:
QSAR & Combinatorial Science. 24:603-610
The nonapeptide hormone oxytocin CYIQNCPLG-NH 2 (OT) controls birth, lactation and other physiological functions in the mammals via stimulation of its receptor (OTR), a member of Class A G protein-coupled receptors (GPCRs). OT is structurally akin to
Publikováno v:
QSAR & Combinatorial Science. 23:536-545
The aim of our research was to get insight into the molecular mechanism of binding atosiban, a strong selective oxytocin (OT) antagonist by OT receptor (OTR) versus vasopressin V1a and V2 receptors (VlaR and V2R, respectively). The docking of ligand
Autor:
Jerzy Trojnar, Josephine Lai, Todd W. Vanderah, Pierre Riviere, Jean Louis Junien, Claudio D. Schteingart
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:326-333
The side effects typically associated with the clinical profiles of opioid mu-receptor agonists have driven continuing efforts to identify novel efficacious analgesics, including agonists acting at opioid kappa receptors. Unfortunately, the therapeut
Autor:
Magdalena J, Slusarz, Rafał, Slusarz, Rajmund, Kaźmierkiewicz, Jerzy, Trojnar, Kazimierz, Wisniewski, Jerzy, Ciarkowski
Publikováno v:
Protein & Peptide Letters. 10:295-302
The neurohypophyseal nonapeptide hormone oxytocin (OT) is the strongest uterotonic substance known and is responsible for the initiation of labor. Conversely, oxytocin antagonists blocking uterine OT receptor can suppress uterus contraction. In this
Publikováno v:
Synthetic Communications. 30:2245-2252
Subsequent treatment of N-crotoyl-(1S,2R)-bornane-10,2-sultam with EtMgCl, recrystallization of the product and saponification, afforded R-(-)-3-methylpenthanoic acid which was used for acylation of (1R,2S)-bornane-10,2-sultam. The product was conver
Autor:
Hiroe Taki, Regent Laporte, Sudar Alagarsamy, Pierre Riviere, Jerzy Trojnar, Marcel Miampamba, Claudio D. Schteingart, Glenn Croston, Kazimierz Wisniewski, Robert Galyean
Publikováno v:
Understanding Biology Using Peptides ISBN: 9780387265698
Introduction Terlipressin (H-Gly3-LVP, GLYPRESSIN ® [1]), 1, is a peptide drug approved in some European and Asian countries for the treatment of bleeding esophageal varices and in France for hepatorenal syndrome. It presumably acts on the vasopress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fa67b94a5c4eafcc229cb728f10a42b
https://doi.org/10.1007/978-0-387-26575-9_210
https://doi.org/10.1007/978-0-387-26575-9_210
Autor:
Kazimierz Wisniewski, Doreen M. Ashworth, Anders Nilsson, Robert Haigh, Per Melin, Chris Yea, Pierre Riviere, Jerzy Trojnar
Publikováno v:
ChemInform. 31
Publikováno v:
Peptides. 13:1233-1237
In connection with our discovery of a strong immunosuppressive activity of cyclolinopeptide A (CLA), we investigated immunosuppressive properties of antamanide and a number of its analogues, including symmetrical antamanide, and compared them with th
Publikováno v:
Collection of Czechoslovak Chemical Communications. 57:1345-1351
N‘-Glycyl, diglycyl and triglycyl [2-~ and [2-~-p-ethyIphenylalanine]oxytocin analogs were synthesized by the solid phase technology utilizing racemic p-ethylphenylalanine. Analogs containing this amino acid of D-configuration were shown to be weak
Autor:
Jerzy Trojnar, Tomislav Barth, Zdenko Procházka, Alena Stierandova, Jiřina Slaninová, Michal Lebl, Per Melin
Publikováno v:
Collection of Czechoslovak Chemical Communications. 57:1335-1344
Solid phase methodology on polyamide-kieselguhr resin was used for the synthesis of six analogs of deamino carba-1 or carba-6 oxytocin with non-coded amino acids in position 2, threonine in position 4, ornithine in position 8 and without glycine in p