Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jerzy Pieczykolan"'
Autor:
Delfina Popiel, Aleksandra Stańczak, Monika Skupińska, Agata Mikołajczyk, Paulina Stańczak, Filip Mituła, Joanna Hucz-Kalitowska, Kinga Jastrzębska, Damian Smuga, Jakub Dominowski, Monika Delis, Krzysztof Mulewski, Wojciech Pietruś, Daria Zdżalik-Bielecka, Karolina Dzwonek, Monika Lamparska-Przybysz, Abdellah Yamani, Patrycja Olejkowska, Natalia Piórkowska, Krzysztof Dubiel, Maciej Wieczorek, Jerzy Pieczykolan
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Fibroblast Growth Factor Receptors (FGFRs) are a family of receptor tyrosine kinases expressed on a plethora of cell membranes. They play crucial roles in both embryonic development and adult tissue functions. There is an increasing amount of evidenc
Externí odkaz:
https://doaj.org/article/07e91621f37e47a8ab05a2c584ceb012
Autor:
Mikolaj Matloka, Sylwia Janowska, Piotr Pankiewicz, Sofiya Kokhanovska, Tomasz Kos, Małgorzata Hołuj, Izabela Rutkowska-Wlodarczyk, Krzysztof Abramski, Monika Janicka, Piotr Jakubowski, Maciej Świątkiewicz, Marlena Welniak-Kaminska, Joanna Hucz-Kalitowska, Paulina Dera, Lukasz Bojarski, Paweł Grieb, Piotr Popik, Maciej Wieczorek, Jerzy Pieczykolan
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Phosphodiesterase 10A (PDE10A) is expressed almost exclusively in the striatum and its inhibition is suggested to offer potential treatment in disorders associated with basal ganglia. We evaluated the selectivity, cytotoxicity, genotoxici
Externí odkaz:
https://doaj.org/article/d453e3c4687c448496b544e69c14dfd4
Autor:
Mariola Stypik, Stanisław Michałek, Nina Orłowska, Marcin Zagozda, Maciej Dziachan, Martyna Banach, Paweł Turowski, Paweł Gunerka, Daria Zdżalik-Bielecka, Aleksandra Stańczak, Urszula Kędzierska, Krzysztof Mulewski, Damian Smuga, Wioleta Maruszak, Lidia Gurba-Bryśkiewicz, Arkadiusz Leniak, Wojciech Pietruś, Zbigniew Ochal, Mateusz Mach, Beata Zygmunt, Jerzy Pieczykolan, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 927 (2022)
Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these proteins in many human cells and the
Externí odkaz:
https://doaj.org/article/a571ed7c657c4ae3a404d1e13d1d6daf
Autor:
Agata Mikolajczyk, Filip Mitula, Delfina Popiel, Bozena Kaminska, Maciej Wieczorek, Jerzy Pieczykolan
Publikováno v:
Cancers, Vol 14, Iss 10, p 2488 (2022)
Receptor tyrosine kinases (RTKs) are transmembrane receptors that bind growth factors and cytokines and contain a regulated kinase activity within their cytoplasmic domain. RTKs play an important role in signal transduction in both normal and maligna
Externí odkaz:
https://doaj.org/article/9bd099b2edf2496b92a694245675911a
Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey.
Autor:
Katarzyna Bazydlo-Guzenda, Pawel Buda, Mateusz Mach, Jerzy Pieczykolan, Izabela Kozlowska, Michal Janiszewski, Ewa Drzazga, Jakub Dominowski, Hubert Ziolkowski, Maciej Wieczorek, Shayne Cox Gad
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257477 (2021)
GPR40 (FFAR1) is a promising target for the managing type 2 diabetes (T2D). The most advanced GPR40 agonist TAK-875 exhibited satisfactory glucose-lowering effects in phase II and III studies. However, the phase III studies of TAK-875 revealed drug-i
Externí odkaz:
https://doaj.org/article/0bb5f2026cea4ecb8832d48ef5bc4190
Autor:
Paweł Gunerka, Kamila Gala, Martyna Banach, Jakub Dominowski, Joanna Hucz-Kalitowska, Krzysztof Mulewski, Agnes Hajnal, Endre G Mikus, Damian Smuga, Marcin Zagozda, Krzysztof Dubiel, Jerzy Pieczykolan, Beata M Zygmunt, Maciej Wieczorek
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236159 (2020)
Asthma is a common chronic inflammatory disease. Although effective asthma therapies are available, part of asthmatic population do not respond to these treatment options. In this work we present the result of development of CPL302-253 molecule, a se
Externí odkaz:
https://doaj.org/article/b8f73c74126948ec925662c8c74b036c
Autor:
Piotr Pankiewicz, Marcin Szybiński, Katarzyna Kisielewska, Filip Gołębiowski, Patryk Krzemiński, Izabela Rutkowska-Włodarczyk, Rafał Moszczyński-Pętkowski, Lidia Gurba-Bryśkiewicz, Monika Delis, Krzysztof Mulewski, Damian Smuga, Jakub Dominowski, Artur Janusz, Michał Górka, Krzysztof Abramski, Agnieszka Napiórkowska, Marcin Nowotny, Krzysztof Dubiel, Katarzyna Kalita, Maciej Wieczorek, Jerzy Pieczykolan, Mikołaj Matłoka
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 704 (2021)
TrkB is a tyrosine kinase receptor that is activated upon binding to brain-derived neurotrophic factor (BDNF). To date, the search for low-molecular-weight molecules mimicking BDNF’s action has been unsuccessful. Several molecules exerting antidepr
Externí odkaz:
https://doaj.org/article/9bb1dda14c4f450caccc553dfbb7d53e
Autor:
Anna M. Serwotka-Suszczak, Alicja M. Sochaj-Gregorczyk, Jerzy Pieczykolan, Daniel Krowarsch, Filip Jelen, Jacek Otlewski
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3676 (2018)
It has been brought to our attention that the affiliation of Dr. Jerzy Pieczykolan at the time when he was responsible for the work described in the paper [...]
Externí odkaz:
https://doaj.org/article/2b4a8f89d7434019bed4658f08a6670b
Autor:
Anna M. Serwotka-Suszczak, Alicja M. Sochaj-Gregorczyk, Jerzy Pieczykolan, Daniel Krowarsch, Filip Jelen, Jacek Otlewski
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 2, p 401 (2017)
Antibody-drug conjugates (ADCs) have recently emerged as efficient and selective cancer treatment therapeutics. Currently, alternative forms of drug carriers that can replace monoclonal antibodies are under intensive investigation. Here, a cytotoxic
Externí odkaz:
https://doaj.org/article/e7b9cb2b66fb4878aa17ff75daddcbc2
Autor:
Anna Bujak, Jerzy Pieczykolan, Maciej Wieczorek, Maria Dulak-Lis, Joanna Hucz-Kalitowska, Krzysztof Szymczak, Martyna Banach, Joanna Miszkiel, Kamila Gala, Bartosz Stypik, Michal Mroczkiewicz, Krzysztof Dubiel, Pawel Gunerka, Beata M. Zygmunt, Urszula Kędzierska
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 4, Pp 340-348 (2021)
Systemic lupus erythematosus is a chronic inflammatory disease, in which treatment is still limited due to suboptimal efficacy and toxicities associated with the available therapies. JAK kinases are well known to play an important role in systemic lu