Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jerzy Michal Dziekan"'
Autor:
Michal Kucharski, Grennady Wirjanata, Sourav Nayak, Josephine Boentoro, Jerzy Michal Dziekan, Christina Assisi, Rob W van der Pluijm, Olivo Miotto, Sachel Mok, Arjen M Dondorp, Zbynek Bozdech
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011118 (2023)
Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa. Although nonsynonymous SNPs in the pfk13 Kelch-repeat propeller (KREP) domai
Externí odkaz:
https://doaj.org/article/7b21338855864a43b06cef5c0fcdb7c0
Autor:
Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle Huon, Isabell Berneburg, Stefan Rahlfs, Jean-Christophe Barale, Sheldon I. Feinstein, Aron B. Fisher, Didier Ménard, Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110923- (2022)
Summary: The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate t
Externí odkaz:
https://doaj.org/article/19eda5da865f4a5c9cee9657e6e2cb8f
Autor:
Grennady Wirjanata, Jerzy Michal Dziekan, Jianqing Lin, El Sahili Abbas, Nur Elyza Binte Zulkifli, Josephine Boentoro, Roy Tham Jun Kai, Seth Tjia, Ka Diam Go, Han Yu, Anthony Partridge, David Olsen, Nayana Prabhu, Radoslaw M. Sobota, Pär Nordlund, Julien Lescar, Zbynek Bozdech
Publikováno v:
SSRN Electronic Journal.
Autor:
Radoslaw M. Sobota, Zbynek Bozdech, Anthony W. Partridge, Pär Nordlund, Nayana Prabhu, Ka Diam Go, Binte Zulkifli Ne, Hao Yu, Jerzy Michal Dziekan, Julien Lescar, Boentoro J, David B. Olsen, Abbas El Sahili, Grennady Wirjanata, Jianqing Lin
Despite their widespread use, our understanding of how many antiparasitic drugs work remains limited. We used mass-spectrometry based cellular thermal shift assay (MS-CETSA) to identify possible protein targets of several malaria drugs and drug candi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4993fa456ed9aa7a135fdc4c37d65ccf
https://doi.org/10.1101/2021.04.08.438947
https://doi.org/10.1101/2021.04.08.438947
Autor:
Jerzy Michal Dziekan, Pär Nordlund, Brenda Puspita, Zbynek Bozdech, Nayana Prabhu, Lingyun Dai, Radoslaw M. Sobota, Ka Diam Go, Liyan Chen, Yan Ting Lim, Han Yu, Loo Chien Wang, Grennady Wirjanata
Despite decades of research, little is known about the cellular targets and the mode of action of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal shift assay (CETSA) protocol in its two variants: the melt c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5f1eb08a66a3219620b0dad6c5a27b
https://hdl.handle.net/10356/155221
https://hdl.handle.net/10356/155221
Autor:
Jerzy Michal, Dziekan, Grennady, Wirjanata, Lingyun, Dai, Ka Diam, Go, Han, Yu, Yan Ting, Lim, Liyan, Chen, Loo Chien, Wang, Brenda, Puspita, Nayana, Prabhu, Radoslaw M, Sobota, Pär, Nordlund, Zbynek, Bozdech
Publikováno v:
Nature protocols. 15(6)
Despite decades of research, little is known about the cellular targets and the mode of action of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal shift assay (CETSA) protocol in its two variants: the melt c
Autor:
Aung Pyae Phyo, Nicholas J. White, François Nosten, Atthanee Jeeyapant, Marina Mc Dew White, Verena I. Carrara, Nicholas P. J. Day, Kamonchanok Konghahong, Charles J. Woodrow, Kanlaya Sriprawat, Tim J. Anderson, Clare L. Ling, Jerzy Michal Dziekan, Shalini Nair, Elizabeth A. Ashley, Mallika Imwong, Zbynek Bozdech, Khin Maung Lwin, Rose McGready, Stephane Proux
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
The pivotal factor leading to the declining efficacy of the artemisinin-based combination on the Thailand–Myanmar border (mefloquine–artesunate) to a clinically unacceptable level is the increasing local prevalence of K13 mutations superimposed o
Autor:
Pär Nordlund, Radoslaw M. Sobota, Grennady Wirjanata, Nayana Prabhu, Zbynek Bozdech, Andreas Larsson, Jerzy Michal Dziekan, Dan Chen, Han Yu, Lingyun Dai
Publikováno v:
Science translational medicine. 11(473)
Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use. Decreasing responsiveness to antimalarial treatments stresses the need for a better resolved understanding of their MoAs and associated resistance mechanisms.
Autor:
Jerzy Michal Dziekan
Mechanisms of action (MoA) have been elusive for most antimalarial drugs in clinical use. Decreasing responsiveness to antimalarial treatments stresses the need of a more resolved understanding of their MoA and associated resistance mechanisms. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce24a8a3ad0f52c0fd7c246d46cae990
http://hdl.handle.net/10220/47871
http://hdl.handle.net/10220/47871