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Reaction of β-cyano esters with hydrazine hydrate. Unexpected formation of dipyrrolo[1,2-b:1′,2′-e][1,2,4,5]tetrazine, a novel ring system

Autor: Tadeusz Jagodzi Ski, Maja Sadowska, Aneta Wesołowska, K. Wejroch, Jerzy Lange, Janina Karolak-Wojciechowska

Publikováno v: Journal of Heterocyclic Chemistry. 42:919-924

Some intermediates and by-products of the title reaction, known to yield 6-hydrazinopyridazine-3-one derivatives, were isolated or detected when the amount of hydrazine hydrate used to react with two model β-cyano esters was reduced to less than two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d956edc5445395f55b0e90bfc7838e5
https://doi.org/10.1002/jhet.5570420525

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Bicyclic [b]-heteroannulated pyridazine derivatives. 9. cyclization reactions of 4,4-dimethyl- and 4-phenyltetrahydropyridazine-3,6-dione 3-hydrazones with esters of keto dicarboxylic acids

Autor: Tadeusz S. Jagodziński, Anna Kielak, Janina Karolak-Wojciechowska, K. Wejroch, Jerzy Lange, Jacek G. Sośnicki

Publikováno v: Journal of Heterocyclic Chemistry. 38:877-884

Bis(ethoxycarbonyl)alkylidene derivatives 4 and 5 of the respective title hydrazones were obtained in the reactions with diethyl oxomalonate, diethyl oxosuccinate, diethyl 2-oxoglutarate, and diethyl oxalo-propionate as mixtures of geometric isomers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86ea6533e5c5613377d07a077e154036
https://doi.org/10.1002/jhet.5570380411

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Structure–activity relationship investigations of the modulating effect of core substituents on the affinity of pyrazoloquinolinone congeners for the benzodiazepine receptor

Autor: Waldemar Ksiazek, Janina Karolak‐Wojciechowska, Małgorzata Gniewosz, Slawomir Rump, Jerzy Lange

Publikováno v: Il Farmaco. 53:579-585

A series of 6- and 7-substituted-2-arylpyrazolo[4,3-c]quinolin-3-ones was synthesized and tested in vitro for binding with the benzodiazepine receptor in competition with [3H]flunitrazepam. Electronic parameters (molecular electrostatic potential (ME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704086a03d36307bba4e67b45180ea96
https://doi.org/10.1016/s0014-827x(98)00072-x

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Bicyclic [b]-heteroannulated pyridazine derivatives.4. Cyclization reactions of 4-aryltetrahydropyridazine-3,6-dione 3-hydrazones with some keto esters

Autor: Plenkiewicz J, Elzbieta Pytlewska, Jerzy Lange, Tomasz Kulinski, Slawomir Rump, Janina Karolak-Wojciechowska

Publikováno v: Journal of Heterocyclic Chemistry. 34:389-396

Ethoxycarbonylalkylidene derivatives 2 and 6 of the title hydrazones were obtained in the reaction with ethyl pyruvate or ethyl aroylformate and ethyl acetoacetate, respectively, in methanol. Both compounds were mixtures of geometric isomers with hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ed6ec1ba0b5d8f61762a5a34dd35a9
https://doi.org/10.1002/jhet.5570340206

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Direct Pyridazine Ring Synthesis fromβ-Cyano Esters. A Facile Synthesis of the Derivatives of Tetrahydro-3,6-pyridazinedione 3-Hydrazone

Autor: Jerzy Lange, Wałgorzata Koberda, Małgorzata Gniewosz, Hanna Tondys

Publikováno v: Synthetic Communications. 23:1371-1377

4-Substituted tetrahydro-3,6-pyridazinedione 3-hydrazones (2) (or their 3-hydrazino tautomers 3), useful intermediates in the synthesis of bicyclic pyridazine derivatives, were prepared in satisfactory yields in the reaction of the corresponding alky

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9b8294bacbc0bcd22b3a0e794e03d40
https://doi.org/10.1080/00397919308011225

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ChemInform Abstract: Some Reductive Transformations in the Furazano(3,4-d)pyridazine System. Formation of 1,2-Dipyridazinyldiazene Derivatives

Autor: Hanna Tondys, Janina Karolak-Wojciechowska, Jerzy Lange

Publikováno v: ChemInform. 23

Hydrogenation of 4,7-diarylfurazano[3,4-d]pyridazine 1-oxides 1 on palladized carbon or platinum oxide yielded 4,5-diamino-3,6-diarylpyridazines 2 and trans-1,2-bis(5-amino-3,6-diaryl-pyridazin-4-yl)diazene 1-oxides 3, readily converted by stannous c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6e97815b79132276f9ec6e8de0a4d1d
https://doi.org/10.1002/chin.199241172

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