Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jerzy Jaskiewicz"'
Autor:
Anna Gawędzka, Jerzy Jaskiewicz, Joanna Gdula-Argasińska, Małgorzata Knapik-Czajka, Jagoda Drag
Publikováno v:
Biochemistry (Moscow). 86:525-532
Fatty acids (FAs) present in the adipose tissue (AT) can be modified by elongases and desaturases. These enzymes are regulated by different factors including nutrients. The aim of the study was to evaluate the impact of high-sucrose diet (HSD; 68% su
Autor:
Jerzy Jaskiewicz, Anna Gozdzialska, Anna Wojas-Pelc, Maciej Pastuszczak, Bogdan Jakiela, Aleksander Obtulowicz
Objectives Approximately 15% of adequately treated patients with early syphilis remain serofast. Pathogenesis and clinical significance of this phenomenon is unclear. The objective of this study was to determine whether there is any association betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2addac7ce214a8c6fab537232414ef83
https://ruj.uj.edu.pl/xmlui/handle/item/95121
https://ruj.uj.edu.pl/xmlui/handle/item/95121
Publikováno v:
Toxicology. 266:1-5
Branched-chain alpha-ketoacid dehydrogense complex (BCKDH) is a regulatory enzyme of valine, isoleucine and leucine catabolism. Its activity is mainly regulated by covalent modification achieved by a specific BCKDH kinase (BDK) and phosphatase (BDP).
Autor:
Mandar Joshi, Jerzy Jaskiewicz, Cheryl B. Bock, Robert A. Harris, Pengfei Wu, Anna A. DePaoli-Roach, Nam Ho Jeoung
Publikováno v:
Biochemical Journal. 397:417-425
The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis. The role of PDHK4 (pyruvate dehydrogenase kinase isoenzyme 4) in regulation of PDC by this mechanism was i
Publikováno v:
Archives of Biochemistry and Biophysics. 381:1-7
Covalent modification of the pyruvate dehydrogenase complex provides an important regulatory mechanism for controlling the disposal of glucose and other compounds metabolized to pyruvate. Regulation of the complex by this mechanism is achieved in par
Publikováno v:
Biochemical Journal. 329:197-201
This study investigated whether conditions known to alter the activity and phosphorylation state of the pyruvate dehydrogenase complex have specific effects on the levels of isoenzymes of pyruvate dehydrogenase kinase (PDK) in rat heart. Immunoblot a
Autor:
Juichi Sato, Yu Zhao, Kirill M. Popov, Jerzy Jaskiewicz, Robert A. Harris, Yoshiharu Shimomura, Thomas D. Hurley, John W. Hawes
Publikováno v:
Europe PubMed Central
Five mitochondrial protein kinases, all members of a new family of protein kinases, have now been identified, cloned, expressed as recombinant proteins, and partially characterized with respect to catalytic and regulatory properties. Four members of
Autor:
Yoshiharu Shimomura, Gary W. Goodwin, J. Irwin, Robert A. Harris, Jerzy Jaskiewicz, Kirill M. Popov, Yu Zhao, Natalia Y. Kedishvili
Publikováno v:
Archives of Biochemistry and Biophysics. 316:148-154
The branched-chain α-ketoacid dehydrogenase complex, catalyst for the rate-limiting step of branched-chain amino acid catabolism, is controlled by a highly specific protein kinase (branched-chain α-ketoacid dehydrogenase kinase) that associates tig
Publikováno v:
Archives of Biochemistry and Biophysics. 315:317-322
3T3-L1 fibroblasts have limited enzymatic capacity to oxidize valine. Enzymes expressed in these cells allow efficient oxidation of only the first carbon of this branched chain amino acid. The pathway is effectively truncated at the level of 3-hydrox
Autor:
Kirill M. Popov, John W. Hawes, Yoshiharu Shimomura, Yu Zhao, David W. Crabb, Robert A. Harris, Jerzy Jaskiewicz
Publikováno v:
Journal of Biological Chemistry. 269:18583-18587
Regulation of the branched chain alpha-ketoacid dehydrogenase complex, the rate-limiting enzyme of branched chain amino acid catabolism, involves phosphorylation of 2 amino acid residues (site 1, serine 293; site 2, serine 303). To directly assess th