Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jerzy E. Kulpa"'
Autor:
Kathryn L. Gilliland, Hans Hofland, David W.C. Hunt, Jerzy E. Kulpa, Diane Thiboutot, Geoffrey C. Winters, Roger W. Brownsey
Publikováno v:
The Journal of investigative dermatology. 137(7)
Olumacostat glasaretil (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first rate-limiting step in fatty acid biosynthesis. Inhibition of ACC activity in the sebaceous glands is designed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a8997b56e7dfe6d863b0b08f9f44fa
https://pubmed.ncbi.nlm.nih.gov/28647025
https://pubmed.ncbi.nlm.nih.gov/28647025
Autor:
Donald McAfee, James D. Johnson, Leonard J. Foster, S. R. Wayne Chen, Edwin D.W. Moore, Parisa Asghari, Nichollas E. Scott, Rich Wambolt, Michael F. Allard, Razvan F. Albu, Jerzy E. Kulpa, Thibault Mayor, Lubos Bohunek, Haoning Cen, Michael J. Bround, Christoph H. Borchers, Jun Han, Marc Pourrier, Roger W. Brownsey, David Fedida
Publikováno v:
The Journal of biological chemistry. 291(45)
Cardiac ryanodine receptor (Ryr2) Ca2+ release channels and cellular metabolism are both disrupted in heart disease. Recently, we demonstrated that total loss of Ryr2 leads to cardiomyocyte contractile dysfunction, arrhythmia, and reduced heart rate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887e34396318750f5977c7d4d9e61d5e
https://pubmed.ncbi.nlm.nih.gov/27621312
https://pubmed.ncbi.nlm.nih.gov/27621312
Publikováno v:
Journal of Biological Chemistry. 285:32606-32615
Elevated extracellular lipids, such as the free fatty acid palmitate, can induce pancreatic beta cell endoplasmic reticulum (ER) stress and apoptosis, thereby contributing to the initiation and progression of type 2 diabetes. ATP-citrate lyase (ACLY)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76dc4443f79ac7ca6519afaed811375
https://doi.org/10.1074/jbc.m110.157172
https://doi.org/10.1074/jbc.m110.157172
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 135:499-513
Cardiac hypertrophy, induced by chronic pressure or volume overload, is associated with abnormalities in energy metabolism as well as characteristic increases in muscle mass and alterations in the structure of the heart. Hypertrophied hearts display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53393923382dbd5221e1b86300c0f90a
https://doi.org/10.1016/s1095-6433(03)00007-2
https://doi.org/10.1016/s1095-6433(03)00007-2
Publikováno v:
Journal of Biological Chemistry. 275:10819-10825
Acetyl-CoA carboxylase (ACC) catalyzes the formation of malonyl-CoA, an essential substrate for fatty acid biosynthesis and a potent inhibitor of fatty acid oxidation. Here, we provide evidence that glutamate may be a physiologically relevant activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb240b652840afdb52b53bc29f571f64
https://doi.org/10.1074/jbc.275.15.10819
https://doi.org/10.1074/jbc.275.15.10819
Autor:
C.H. Borchers, Jerzy E. Kulpa, L. Bohunek, Michael F. Allard, Marc Pourrier, Roger W. Brownsey, Richard B. Wambolt, J.D. Johnson, D. McAfee, M.J. Bround, J. Han, David Fedida
Publikováno v:
Canadian Journal of Cardiology. 30:S206-S207
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73fb2680abc7913295bb3a3a7c0aad21
https://doi.org/10.1016/j.cjca.2014.07.339
https://doi.org/10.1016/j.cjca.2014.07.339
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f337e5cb6170b087593313b08e4fa8f5
https://doi.org/10.1096/fasebj.22.1_supplement.620.4
https://doi.org/10.1096/fasebj.22.1_supplement.620.4
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d1f37e0aa1a9279fc86dd397bdd7b68
https://doi.org/10.1096/fasebj.22.1_supplement.1162.3
https://doi.org/10.1096/fasebj.22.1_supplement.1162.3
Autor:
Dan S. Luciani, Lubos Bohunek, Farnaz Taghizadeh, James D. Johnson, Jerzy E. Kulpa, Edwin D.W. Moore, Michael J. Bround, Brian Rodrigues, Parisa Asghari, Rich Wambolt, Michael F. Allard, Kenneth R. Boheler, Roger W. Brownsey
Publikováno v:
Canadian Journal of Diabetes. 36:S52
s / Can J Diabetes 36 (2012) S24eS76 S52 (NCS) protocols and lack of predictive biomarkers. We aimed to determine the performance of single and simple combinations of NCS parameters for identification and future prediction of DSP. Methods: 406 partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a283b7349c1749d74b3f54e4f6f3cc
https://doi.org/10.1016/j.jcjd.2012.07.379
https://doi.org/10.1016/j.jcjd.2012.07.379
Autor:
C. Smits, E.D. Moore, M.J. Bround, Michael F. Allard, D.S. Luciani, E.G. Lakatta, P. Asghari, Richard B. Wambolt, Roger W. Brownsey, J.D. Johnson, K.R. Boheler, Brian Rodrigues, Jerzy E. Kulpa, L. Bohunek, F. Taghizadeh
Publikováno v:
Canadian Journal of Cardiology. 28:S270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97efc81dcd2b549215d849faf2254f21
https://doi.org/10.1016/j.cjca.2012.07.426
https://doi.org/10.1016/j.cjca.2012.07.426