Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Jerzy Ciarkowski"'
Publikováno v:
TASK Quarterly, Vol 2, Iss 4 (2021)
G protein-coupled receptors (GPCRs) are the most frequent targets for many drugs. They form the largest superfamily of integral membrane proteins, of which more than 1000 members have the following common features: (i) All GPCRs form 7 hydrophobic a-
Externí odkaz:
https://doaj.org/article/5c99a9f63efc406788559fd055fa5e5f
Autor:
Artur Gieldon, Dorota Zurawa-Janicka, Miroslaw Jarzab, Tomasz Wenta, Przemyslaw Golik, Grzegorz Dubin, Barbara Lipinska, Jerzy Ciarkowski
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161526 (2016)
HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain
Externí odkaz:
https://doaj.org/article/0cede49dcda843cd9eae55c536739ae6
Autor:
PIOTR ARŁUKOWICZ, EWA BIERNAT, JERZY CIARKOWSKI, CEZARY CZAPLEWSKI, MAŁGORZATA GROTH, RAJMUND KAŹMIERKIEWICZ, ADAM LIWO, KATARZYNA MAKSIMIAK, MAŁGORZATA NOWACKA, STANISŁAW OŁDZIEJ, SYLWIA RODZIEWICZ, EDYTA WOŹNIAK
Publikováno v:
TASK Quarterly, Vol 1, Iss 1 (1997)
In this article, we present the work carried out in our group on various fields of theoretical biochemistry. Our main fields of research are as follows: i) design of an algorithm fordc novo prediction of protein structure from amino-acid sequence usi
Externí odkaz:
https://doaj.org/article/3e21ba25314545ffbbcf3602b2bb1e89
Autor:
Dorota Zurawa-Janicka, Barbara Lipinska, Tomasz Wenta, Joanna Skorko-Glonek, Przemyslaw Glaza, Artur Giełdoń, Miroslaw Jarzab, Jerzy Ciarkowski
Publikováno v:
Archives of Biochemistry and Biophysics. 621:6-23
Human HtrA1-4 proteins belong to the HtrA family of evolutionarily conserved serine proteases and function as important modulators of many physiological processes, including maintenance of mitochondrial homeostasis, cell signaling and apoptosis. Dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a8dc941620b93b6aa2e0934d5e9368
https://doi.org/10.1016/j.abb.2017.04.004
https://doi.org/10.1016/j.abb.2017.04.004
Autor:
Dariusz Sobolewski, Jerzy Ciarkowski, Emilia A. Lubecka, Jiřina Slaninová, Adam Prahl, Emilia Sikorska
Publikováno v:
Biopolymers. 106:245-259
Deamination of vasopressin (AVP) enhances its antidiuretic activity. Moreover, introduction of D-Arg8 instead of its L enantiomer in deamino-vasopressin (dAVP) results in an extremely potent and selective antidiuretic agonist - desmopressin (dDAVP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::697488616702ae6400ec85461351146f
https://doi.org/10.1002/bip.22825
https://doi.org/10.1002/bip.22825
Autor:
Barbara Lipinska, Tomasz Wenta, Przemyslaw Glaza, Miroslaw Jarzab, Agnieszka Polit, Magdalena Wysocka, Jerzy Ciarkowski, Joanna Skorko-Glonek, Adam Lesner, Dorota Zurawa-Janicka, Artur Giełdoń
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1864:283-296
HtrA2(Omi) protease is involved in the maintenance of mitochondrial homeostasis and stimulation of apoptosis as well as in development of cancer and neurodegenerative disorders. The protein is a homotrimer whose subunits comprise serine protease doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e18356d75c84a7c24e303a6ec20e07
https://doi.org/10.1016/j.bbapap.2015.12.002
https://doi.org/10.1016/j.bbapap.2015.12.002
Autor:
Aleksandra S. Kołodziejczyk, Martyna Maszota, Jerzy Ciarkowski, Paulina Czaplewska, Sylwia Rodziewicz-Motowidło, Natalia Karska, Marta Spodzieja
Publikováno v:
Journal of Molecular Recognition. 28:413-426
Serum amyloid A (SAA) is a multifunctional acute-phase protein whose concentration in serum increases markedly following a number of chronic inflammatory and neoplastic diseases. Prolonged high SAA level may give rise to reactive systemic amyloid A (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967836ec3b3a67b6eb204bab5636014e
https://doi.org/10.1002/jmr.2457
https://doi.org/10.1002/jmr.2457
Autor:
Tomasz Koper, Jerzy Ciarkowski, Agnieszka Polit, Anna Sobiecka-Szkatula, Artur Giełdoń, Joanna Skorko-Glonek, Bogdan Banecki, Barbara Lipinska, Adam Lesner, Milena Denkiewicz, Donata Figaj
Publikováno v:
Journal of Biological Chemistry. 289:15880-15893
Bacterial HtrAs are serine proteases engaged in extracytoplasmic protein quality control and are required for the virulence of several pathogenic species. The proteolytic activity of HtrA (DegP) from Escherichia coli, a model prokaryotic HtrA, is sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f6c21b0bed6cbf458ea934ec4b46dfd
https://doi.org/10.1074/jbc.m113.532895
https://doi.org/10.1074/jbc.m113.532895
Publikováno v:
Journal of Peptide Science. 20:406-414
Two glycosylated peptides have been studied using NMR spectroscopy supported by molecular modeling. Peptide I is an oxytocin (OT) analogue in which glutamine 4 was replaced by serine with attached α-d-mannose through the oxygen β atom, whereas pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0400b14b36416fe7e21576750fae6da5
https://doi.org/10.1002/psc.2628
https://doi.org/10.1002/psc.2628
Publikováno v:
Chemical Biology & Drug Design. 79:1033-1042
In this paper, we investigated the structure-activity relationship of two vasopressin analogues, [Cpa(1),(L-1-Nal)(2) ]AVP (I) and [Cpa(1),(D-Nal)(2) ]AVP (II) by NMR spectroscopy and molecular modeling. Both peptides exhibit antioxytocic and antipre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55f74a07c941f1e2892f6503c9e037b4
https://doi.org/10.1111/j.1747-0285.2012.01358.x
https://doi.org/10.1111/j.1747-0285.2012.01358.x