Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Jerson L, Silva"'
Autor:
Elaine C. Petronilho, Guilherme C. de Andrade, Gileno dos S. de Sousa, Fernando P. Almeida, Michelle F. Mota, Ana Vitória dos S. Gomes, Carlos Henrique S. Pinheiro, Mylena C. da Silva, Hiam R. S. Arruda, Mayra A. Marques, Tuane C. R. G. Vieira, Guilherme A. P. de Oliveira, Jerson L. Silva
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract P53 Phase separation is crucial towards amyloid aggregation and p63 and p73 have enhanced expression in tumors. This study examines the phase behaviors of p53, p63, and p73. Here we show that unlike the DNA-binding domain of p53 (p53C), the
Externí odkaz:
https://doaj.org/article/00b9e9a826c54afface84a0c4a7613a7
Autor:
Mariana M. Paz, Giulia D. S. Ferretti, Mafalda M. C. Martins-Dinis, Beatriz I. S. Ferreira, Amanda Faier-Pereira, Thibaut Barnoud, Otacilio C. Moreira, Jerson L. Silva, Yraima Cordeiro, Luciana P. Rangel
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Although many therapeutic options are available, several factors, including the presence of p53 mutations, impact tumor development and therapeutic resistan
Externí odkaz:
https://doaj.org/article/a63a21b730f141c89ca914e08c92a1d4
Autor:
Fabricia L. Fontes-Dantas, Gabriel G. Fernandes, Elisa G. Gutman, Emanuelle V. De Lima, Leticia S. Antonio, Mariana B. Hammerle, Hannah P. Mota-Araujo, Lilian C. Colodeti, Suzana M.B. Araújo, Gabrielle M. Froz, Talita N. da Silva, Larissa A. Duarte, Andreza L. Salvio, Karina L. Pires, Luciane A.A. Leon, Claudia Cristina F. Vasconcelos, Luciana Romão, Luiz Eduardo B. Savio, Jerson L. Silva, Robson da Costa, Julia R. Clarke, Andrea T. Da Poian, Soniza V. Alves-Leon, Giselle F. Passos, Claudia P. Figueiredo
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112189- (2023)
Summary: Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood. Evidence suggests that severe acute respiratory syndrome coronavirus 2 (
Externí odkaz:
https://doaj.org/article/fe134363e486421c960c5fd3b4c479bc
Autor:
Hiam R.S. Arruda, Tulio M. Lima, Renata G.F. Alvim, Fernanda B.A. Victorio, Daniel P.B. Abreu, Federico F. Marsili, Karen D. Cruz, Mayra A. Marques, Patricia Sosa-Acosta, Mauricio Quinones-Vega, Jéssica de S. Guedes, Fábio C.S. Nogueira, Jerson L. Silva, Leda R. Castilho, Guilherme A.P. de Oliveira
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105696- (2023)
Summary: The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19. Here, we present compar
Externí odkaz:
https://doaj.org/article/082a714a76334ef283c20689581f07d8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The p53 protein is a pleiotropic regulator working as a tumor suppressor and as an oncogene. Depending on the cellular insult and the mutational status, p53 may trigger opposing activities such as cell death or survival, senescence and cell cycle arr
Externí odkaz:
https://doaj.org/article/159cc2e9f3654f5da6710a51168d4e18
Autor:
Luis Eduardo R. Cunha, Adilson A. Stolet, Marcelo A. Strauch, Victor A.R. Pereira, Carlos H. Dumard, Andre M.O. Gomes, Fábio L. Monteiro, Luiza M. Higa, Patrícia N.C. Souza, Juliana G. Fonseca, Francisco E. Pontes, Leonardo G.R. Meirelles, José W.M. Albuquerque, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Tulio M. Lima, Renata G.F. Alvim, Federico F. Marsili, Marcella Moreira Caldeira, Russolina B. Zingali, Guilherme A.P. de Oliveira, Thiago M.L. Souza, Alexandre S. Silva, Rodrigo Muller, Daniela del Rosário Flores Rodrigues, Luciana Jesus da Costa, Arthur Daniel R. Alves, Marcelo Alves Pinto, Andréa C. Oliveira, Herbert L.M. Guedes, Amilcar Tanuri, Leda R. Castilho, Jerson L. Silva
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103315- (2021)
Summary: We used the recombinant trimeric spike (S) glycoprotein in the prefusion conformation to immunize horses for the production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by ELISA were above 1:106, and the neutra
Externí odkaz:
https://doaj.org/article/fd393a9b9edf40629a376603a387320c
Autor:
Ana C. Vicente Santos, Francisca H. Guedes-da-Silva, Carlos H. Dumard, Vivian N. S. Ferreira, Igor P. S. da Costa, Ruana A. Machado, Fernanda G. Q. Barros-Aragão, Rômulo L. S. Neris, Júlio S. dos-Santos, Iranaia Assunção-Miranda, Claudia P. Figueiredo, André A. Dias, Andre M. O. Gomes, Herbert L. de Matos Guedes, Andrea C. Oliveira, Jerson L. Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
Zika virus (ZIKV) emerged as an important infectious disease agent in Brazil in 2016. Infection usually leads to mild symptoms, but severe congenital neurological disorders and Guillain-Barré syndrome have been reported following ZIKV exposure. Crea
Externí odkaz:
https://doaj.org/article/cfd630acb424434ca57acb58b694898d
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11023 (2022)
p53 is a tumor suppressor protein that is mutated in more than 50% of cancer cases. When mutated, it frequently results in p53 oncogenic gain of function (GOF), resulting in a greater tendency to aggregate in the phase separation and phase transition
Externí odkaz:
https://doaj.org/article/0e51046bd038434d8614389de40b34f3
Autor:
Juliana N. Angelli, Yulli M. Passos, Julyana M. A. Brito, Jerson L. Silva, Yraima Cordeiro, Tuane C. R. G. Vieira
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Prion diseases have been described in humans and other mammals, including sheep, goats, cattle, and deer. Since mice, hamsters, and cats are susceptible to prion infection, they are often used to study the mechanisms of prion infection and conversion
Externí odkaz:
https://doaj.org/article/2e745eb959274478866147910581671a
Publikováno v:
Essays in Biochemistry. 66:1023-1033
In 1972, the Weber statement, “The multiplicity of interactions and the variety of effects that follow from them show that multimer proteins are unlikely to be limited to a minimal number of allowed conformations,” first addressed the dynamic nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b743806c65728486e258bf25eb971d
https://doi.org/10.1042/ebc20220064
https://doi.org/10.1042/ebc20220064