Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jerry Z. Yang"'
Publikováno v:
Communications in Mathematical Sciences. 20:359-375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66d8c87833a645b8879e03395370c3a4
https://doi.org/10.4310/cms.2022.v20.n2.a3
https://doi.org/10.4310/cms.2022.v20.n2.a3
Autor:
Li Xing, Devadas Balekudru, Jerry Z. Yang, Michael Mao, Elizabeth G. Webb, Joseph B. Monahan, Gary D. Anderson, Brian Samas, Dean Messing, Huey S. Shieh, John K. Walker, Rajesh V. Devraj, Shaun R. Selness
Publikováno v:
ChemMedChem. 7:273-280
PH-797804 ((aS)-3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamde) is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase derived from a racemic mixture as the more potent atropisomer (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5687de363aa7e63f5520098e7c45c8b
https://doi.org/10.1002/cmdc.201100439
https://doi.org/10.1002/cmdc.201100439
Autor:
Barbara A. Schweitzer, Atli Thorarensen, Michael S. Davies, Steve R. Turner, Matthew James Pelc, James R. Kiefer, Brenda L. Case, Christie L. Funckes-Shippy, Jacqueline E. Day, Fengmei Hua, Dice Tom, William M. Abraham, Bradley E. Neal, John I. Trujillo, Joseph B. Moon, Blake Tanisha Danielle Rowe, Wei Huang, Craig D. Wegner, Dean Welsch, Chris P. Carron, Anup Zutshi, Bruce C. Hamper, Chad J. Warren, Rhonda S. Woerndle, Christine M. Kornmeier, Vickie M. Dilworth, Melanie L. Williams, Martin E. Dowty, Olson Kirk Lang, Melissa R. Radabaugh, Becky L. Hood, Jerry Z. Yang, Douglas C. Rohrer, Gina M. Jerome, Christine P. Bono
Publikováno v:
ACS Medicinal Chemistry Letters. 1:59-63
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6559b7ee90a239bc2255e65f4dd700
https://doi.org/10.1021/ml900025z
https://doi.org/10.1021/ml900025z
Publikováno v:
Journal of Pharmaceutical Sciences. 93:1185-1194
The bidirectional permeation characteristics of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein (P-gp), across monolayers of MDCK cells transfected with the human MDR1 gene (MDCK–MDR1) were investigated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8b6c16a56936dc3eba81e380378ea8
https://doi.org/10.1002/jps.20046
https://doi.org/10.1002/jps.20046
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:840-848
In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs (acyloxyalkoxy-based cyclic prodrug of DADLE, coumarinic acid-based cyclic prodrug of DADLE, and oxymethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17ba856c1df53f3755c1504adc5f72c
https://doi.org/10.1124/jpet.102.037135
https://doi.org/10.1124/jpet.102.037135
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:849-857
The permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs [acyloxyalkoxy-based cyclic prodrug of DADLE (AOA-DADLE), coumarinic acid-based cyclic prodrug of DADLE (CA-DALE), and oxymethyl-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b765e669f29a051f83bd26567f044b
https://doi.org/10.1124/jpet.102.037143
https://doi.org/10.1124/jpet.102.037143
Publikováno v:
Journal of Chromatography B. 780:269-281
Two analytical methods were developed for quantitative determination of DADLE (H(2)N-Tyr-D-Ala-Gly-Phe-D-Leu-COOH) and its two cyclic prodrugs in rat plasma. For high-performance liquid chromatography with fluorescence detection (LC-FLU), precolumn d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa3eab259a42ffa3ecccb515684bb47
https://doi.org/10.1016/s1570-0232(02)00536-6
https://doi.org/10.1016/s1570-0232(02)00536-6
Autor:
Rajesh V. Devraj, Heather M. Madsen, Heidi M. Morgan, Laura D. Marrufo, Gary D. Anderson, Shaun R. Selness, Dean Messing, Elizabeth G. Webb, Joseph B. Monahan, Jian Zhang, Devadas Balekudru, Jerry Z. Yang, Huey S. Shieh, Li Xing
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(13)
A novel series of highly potent and selective p38 MAP kinase inhibitors was developed originating from a substituted N-aryl-6-pyrimidinone scaffold. SAR studies coupled with in vivo evaluations in rat arthritis model culminated in the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c50bfd334c3732636cf4d80aaa2300c
https://pubmed.ncbi.nlm.nih.gov/21620699
https://pubmed.ncbi.nlm.nih.gov/21620699
Publikováno v:
Journal of pharmaceutical sciences. 97(11)
This manuscript describes the preparation, characterization, and pharmacokinetic studies for fluticasone and budesonide nanosuspensions in pulmonary delivery. A wet-milling method with glass beads was evaluated for formulation preparation. Based on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0b3391ea4e60e469509467fef9857b
https://pubmed.ncbi.nlm.nih.gov/18351635
https://pubmed.ncbi.nlm.nih.gov/18351635
Autor:
Jerry Z. Yang
Publikováno v:
MRS Proceedings. 978
The accuracy of the quasicontinuum method is studied by reformulating the summation rules in terms of reconstruction schemes for the local atomic environment of the representative atoms. The necessary and sufficient condition for uniform first order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62fa161f39963f6846eda8b0a32ace06
https://doi.org/10.1557/proc-978-0978-gg01-02
https://doi.org/10.1557/proc-978-0978-gg01-02