Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jerry W. Skiles"'
Autor:
David Farley, Leslie Wighton Mcquire, Karen Toscano, Noela Reel, Song Xue, James Fang, Elizabeth Quadros, Ronald L. Goldberg, J. R. Doughty, Siyuan Zhou, Robert Goldstein, Raviraj Kulathila, Joseph Somers, Gary Pastor, V. Blancuzzi, H. N. Singh, Stacey LaVoie, Robert A. Doti, Lauren G. Monovich, Kirk Clark, Tommasi Ruben A, Dennis M. Roland, John Fitt, Lijuan Zhu, Elizabeth O'Byrne, Vishwas Ganu, Jerry W. Skiles, Wen-Chung Shieh, David Thomas Parker, Theodore C. Pellas, Yumi Sakane, Andrew Wigg, Wendy D. Cornell, Richard Melton, William Macchia, Roger Aki Fujimoto
Publikováno v:
Journal of Medicinal Chemistry. 52:3523-3538
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would therefore be a novel disease modifying therapy for the treatment of a
Publikováno v:
Current Medicinal Chemistry. 11:2911-2977
Matrix metalloproteinases (MMPs) are a family of zinc-containing enzymes involved in the degradation and remodeling of extracellular matrix proteins. Under normal physiological conditions, the activities of these enzymes are well-regulated by endogen
Publikováno v:
Frontiers in Medicinal Chemistry - Online. 1:29-75
Publikováno v:
Tetrahedron: Asymmetry. 10:3263-3266
The rapid simultaneous determination of enantiomeric purity and erythro / threo relationship for a series of chiral 1,2-aminoalcohols is reported. Complexation with 1 equivalent ( R )-(+)- t -butylphenylphosphinothioic acid results in a preferred con
Autor:
Jerry W. Skiles, Arco Y. Jeng
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:869-895
The fibrous protein elastin, which comprises an appreciable percentage of all protein content in some tissues, such as arteries, some ligaments, and the lungs, can be hydrolysed or otherwise destroyed by a select group of enzymes classified as elasta
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:963-966
The asymmetric synthesis of cis-(−)-(2R4S)-4-(phosphononomethyl)-2-piperidinecarboxylic acid (1), a potent and specific NMDA receptor antagonist, via an olefin-iminium cyclization is described.
Autor:
Stephen Jacober, Philip W. Mui, Jerry W. Skiles, Sorcek Ronald J, Miao Clara K, Alan S. Rosenthal, Mcneil Daniel W
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:773-778
The synthesis of potential human leukocyte elastase (HLE) inhibitors containing conformationally restricted lactams as peptidomimetic replacements at P3-P2 and which contain a trifluoromethyl ketone of valine at P1 are described.
Autor:
Suresh R. Kapadia, Janice M. Klunder, W. W. Engel, John R. Proudfoot, Guenther Schmidt, S. C. Mauldin, Usha R. Patel, Janice M. Rose, Alan S. Rosenthal, Kollol Pal, K. D. Hargrave, T. D. Saboe, Scot J. Campbell, Jerry W. Skiles, Mark L. Behnke, Mark T. Skoog, Joe C. Wu, W. G. Eberlein, Jana Vitous, Julian Adams, Grace C. Chow, Ernest Cullen, Grozinger Karl G, Victor Fuchs, Mcneil Daniel W
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
The synthesis of imidazo[1,2-a]piperazines bearing a trifluoromethyl substituent, potential inhibitors of serine proteinases, is illustrated.
Autor:
Victor Fuchs, Janice M. Rose, Kollol Pal, Mark L. Behnke, Wolfhard W. Engel, Usha R. Patel, Scot J. Campbell, Suresh R. Kapadia, Julian Adams, Jerry W. Skiles, Joe C. Wu, Gunther Schmidt, Grozinger Karl G, Alan S. Rosenthal, Tracy D. Saboe, Wolfgang G. Eberlein, Jana Vitous, Janice M. Klunder, John R. Proudfoot, Ernest Cullen, Mark T. Skoog, Mcneil Daniel W, Scott C. Mauldin, Grace C. Chow, Karl D. Hargrave
Publikováno v:
Journal of Medicinal Chemistry. 34:2231-2241
Novel pyrido[2,3-b][1,4]benzodiazepinones (I), pyrido[2,3-b][1,5]benzodiazepinones (II), and dipyrido[3,2-b:2',3'-e][1,4]diazepinones (III) were found to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in vitro at concentrat