Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jerry W, Cubbage"'
Autor:
Sandra W. Curtiss, D. Joseph Rogier, Alan MacInnes, Brown David L, Mike B. Tollefson, Brian R. Bond, Yvette M. Fobian, Maddux Todd Michael, Dafydd R. Owen, Jeanne M. Rumsey, Brent V. Mischke, Jerry W. Cubbage, Alan G. Benson, Robert Hughes, Lena L Zhang, E. Jon Jacobsen, Steven E. Heasley, Joseph B. Moon, Ying Yu, John M. Molyneaux, Yi Zheng, Brad A. Acker, Blevis-Bal Radhika M, John N. Freskos, John K. Walker, Jennie L. Walgren
Publikováno v:
Journal of Medicinal Chemistry. 53:2656-2660
We recently described a novel series of aminopyridopyrazinones as PDE5 inhibitors. Efforts toward optimization of this series culminated in the identification of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892c7788c8aa398973abd4f8bb5a78a5
https://doi.org/10.1021/jm901781q
https://doi.org/10.1021/jm901781q
Autor:
Maddux Todd Michael, Yvette M. Fobian, Alan G. Benson, Dafydd R. Owen, Brian R. Bond, Christopher Phillips, Brad A. Acker, E. Jon Jacobsen, Michael John Palmer, D. Joseph Rogier, John M. Molyneaux, Brent V. Mischke, John N. Freskos, Tracy J. Ringer, Andrew Simon Bell, Blevis-Bal Radhika M, Robert Hughes, David G. Brown, Steve E. Heasley, Joseph B. Moon, John K. Walker, Brown David L, William C. Stallings, Michael B. Tollefson, Alan MacInnes, Jerry W. Cubbage, Yung Yu, Margarita Rodriquez-Lens, Fox David Nathan Abraham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4088-4091
A new class of potent and selective PDE5 inhibitors is disclosed. Guided by X-ray crystallographic data, optimization of an HTS lead led to the discovery of a series of 2-aryl, (N8)-alkyl substituted-6-aminosubstituted pyrido[3,2b]pyrazinones which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5005db6742e606fdadbf520ea66a63a9
https://doi.org/10.1016/j.bmcl.2009.06.012
https://doi.org/10.1016/j.bmcl.2009.06.012
Publikováno v:
Applied Catalysis B: Environmental. 54:105-114
The partial photocatalytic degradation of maleic acid has been investigated with the purpose of elucidating the mechanism of catalyst action for some of the early transformations. In particular, it is proposed that the photocatalytically induced cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e32786862a7634be2af221bb7ed00582
https://doi.org/10.1016/j.apcatb.2004.05.024
https://doi.org/10.1016/j.apcatb.2004.05.024
Publikováno v:
Journal of Physical Organic Chemistry. 15:71-77
The barriers to pyrolytic unimolecular elimination by ethyl methanesulfonate and ethyl methanesulfinate were calculated for both five-membered ring eliminations that yield acetaldehyde and six-membered ring eliminations that yield ethylene. The exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa877625e44c4c732cb927ed5fffa110
https://doi.org/10.1002/poc.464
https://doi.org/10.1002/poc.464
Publikováno v:
The Journal of Organic Chemistry. 66:8722-8736
Gas-phase activation data were obtained for model sulfoxide elimination reactions. The activation enthalpy for methyl 3-phenylpropyl sulfoxide is 32.9 +/- 0.9 kcal/mol. Elimination by methyl vinyl sulfoxide to form acetylene has an enthalpic barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de0da611b89ef2d8d8a51d013e59fc2
https://doi.org/10.1021/jo0160625
https://doi.org/10.1021/jo0160625
Autor:
William S. Jenks, Jerry W. Cubbage
Publikováno v:
The Journal of Physical Chemistry A. 105:10588-10595
A computational study on ground and excited states of dimethyl sulfoxide (DMSO) and the hypothetical molecule H2SO is reported. Full valence CASSCF/6-311+G(3df,2p) with a multireference perturbation theory correction was used for the latter, while DM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2f117ee73b79952869691bdb47ed4c
https://doi.org/10.1021/jp012351l
https://doi.org/10.1021/jp012351l
Publikováno v:
Journal of Photochemistry and Photobiology A: Chemistry. 143:69-85
The early degradation product distributions from TiO2-mediated photocatalytic degradations of a series of multiply hydroxylated benzenes and their methoxylated analogs is reported. The methoxylated compounds show a distinct trend away from ring-openi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7df0698820affa60c79c736de0e4953a
https://doi.org/10.1016/s1010-6030(01)00472-5
https://doi.org/10.1016/s1010-6030(01)00472-5
Publikováno v:
Journal of the American Chemical Society. 122:4968-4971
Thermolysis of methyl 3-phenylpropyl sulfone in the gas phase results in formation of allylbenzene. Activation parameters of ΔH⧧ = 53.5 ± 1.0 kcal/mol and ΔS⧧ = −0.7 ± 1.4 cal/(mol·K) were obtained over the range of 490−550 °C. Similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::845509a77b23e6825ac3735c5d6e22d7
https://doi.org/10.1021/ja994150p
https://doi.org/10.1021/ja994150p
Publikováno v:
The Journal of Organic Chemistry. 64:8509-8524
Complete mineralization of 4-chlorophenol in water can be achieved by photocatalytic degradation of oxygenated solutions containing suspended TiO2. The chemical pathways of this degradation are complex, and in this paper, that which begins with hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05985f8baa9062b561e333cb17f9d06d
https://doi.org/10.1021/jo990820y
https://doi.org/10.1021/jo990820y