Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jerry Styles"'
Autor:
Jin Li, John F. Thompson, Ayman A.A. Ewies, Ian N.H. White, Farook Al-Azzawi, Adrian G. Stanley, Mona El-Shafie, Jerry Styles
Publikováno v:
Molecular Human Reproduction. 14:127-135
Failure of ligamentous support of the genital tract to resist intra-abdominal pressure is a plausible underlying mechanism for the development of pelvic organ prolapse, but the nature of the molecular response of pelvic tissue support remains unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b93eda11d75e88968dadb278346aa3
https://doi.org/10.1093/molehr/gam090
https://doi.org/10.1093/molehr/gam090
Publikováno v:
Endocrine-Related Cancer. 14:337-350
In this study, the oestrogen agonist/antagonist action of 4-hydroxytamoxifen (OHT; 1 × 10−6 M) and 17β-oestradiol (E2; 1 × 10−8 M) were assessed on the oestrogen receptor (ER)-positive epithelial cell line (Ishikawa) with respect to cell proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34f52bf3f429bed174e5024bdf6da62
https://doi.org/10.1677/erc-06-0085
https://doi.org/10.1677/erc-06-0085
Autor:
Jerry Styles, Emma Horner-Glister, Suzanne M. Johnson, C J Guerin, Ian N.H. White, M Maleki-Dizaji
Publikováno v:
Journal of Molecular Endocrinology. 35:421-432
Tamoxifen acts as an oestrogen antagonist in the breast reducing cell proliferation, but in the uterus as an oestrogen agonist resulting in increased cell proliferation. Tamoxifen exerts its tissue-specific effects through the oestrogen receptors (ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a01b25e4187a816099a80a1a64463b3
https://doi.org/10.1677/jme.1.01784
https://doi.org/10.1677/jme.1.01784
Publikováno v:
Cancer Letters. 171:27-35
The anti-oestrogenic drug tamoxifen has been under investigation as a breast cancer chemopreventive agent for at least a decade. However, its use for this purpose is still debatable since it is able to induce liver tumours in rats via a mechanism inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a98a8b18d014e0efd7d06e36ecbb33b
https://doi.org/10.1016/s0304-3835(01)00564-x
https://doi.org/10.1016/s0304-3835(01)00564-x
Autor:
Reginald Davies, Karen Brown, Lewis L. Smith, Elizabeth A. Martin, John E. Brown, Philip Carthew, Ian N.H. White, Jerry Styles
Publikováno v:
Carcinogenesis. 22:553-557
It is now generally accepted that activation of tamoxifen occurs as a result of metabolism to alpha-hydroxytamoxifen. In this study, alpha-hydroxytamoxifen was given to female Wistar/Han rats (0.103 or 0.0103 mmol/kg, intraperitoneally, daily for 5 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdb8133357c13db7617ab6a6707291e
https://doi.org/10.1093/carcin/22.4.553
https://doi.org/10.1093/carcin/22.4.553
Autor:
Jerry Styles, Doron Lipson, Andrew G. Smith, Joan Riley, Nicola J. Turton, Reginald Davies, David J. Judah, Timothy W. Gant
Publikováno v:
Oncogene. 20:1300-1306
The multidrug resistance (MDR) phenotype is a major cause of cancer treatment failure. Here the expressions of 4224 genes were analysed for association with intrinsic or acquired doxorubicin (DOX) resistance. A cluster of overexpressed genes related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbc9910423cf6ce28ab29e9b73a8559
https://doi.org/10.1038/sj.onc.1204235
https://doi.org/10.1038/sj.onc.1204235
Autor:
Lesley A Stanley, Richard D. Verschoyle, Joan Riley, Ian N.H. White, Jerry Styles, Timothy W. Gant
Publikováno v:
Biochemical Pharmacology. 60:233-239
ATPase transporter proteins are commonly found in the hepatocyte canalicular membrane. Some of these, in particular the multidrug resistance ( mdr1b ) gene, have been previously demonstrated to be inducible genes. In this study, we found that tamoxif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ef2b8c426cd0a79d979efdbbee559e
https://doi.org/10.1016/s0006-2952(00)00326-9
https://doi.org/10.1016/s0006-2952(00)00326-9
Autor:
Jerry Styles, Lewis L. Smith, Victor I. C. Oreffo, Ian N.H. White, Kathryn S. Lilley, Stuart Bayliss, Reginald Davies, Phuong-Anh Dinh
Publikováno v:
Environmental and Molecular Mutagenesis. 28:430-433
Tamoxifen, an important drug in breast cancer treatment, causes liver cancer in rats. The standard range of in vitro tests have failed to show that it causes DNA damage, but 32P-postlabelling and DNA-binding studies have shown that tamoxifen forms DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b4b473a0dc36127a708927bb10b680
https://doi.org/10.1002/(sici)1098-2280(1996)28:4<430::aid-em19>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1996)28:4<430::aid-em19>3.0.co
Publikováno v:
Carcinogenesis. 16:1127-1133
Trichloroacetic acid (TCA) was tested for its ability to induce chromosomal damage in cultured human peripheral blood lymphocytes and in bone marrow cells of male and female C57BL/6J f BL10/Alpk mice. Two in vino cytogenetic assays were conducted wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f818f5787692536f34b22b023be9a85d
https://doi.org/10.1093/carcin/16.5.1127
https://doi.org/10.1093/carcin/16.5.1127
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 59(3-4)
The effects of subcutaneous dosing of neonatal CD-1 mice with tamoxifen on days 1–5 after birth at doses of 0, 5, 10, 25 or 50 μg/pup or with 4-hydroxyoestradiol at 2 μg/pup have been investigated. Animals were culled at 1.5, 3, 6, 12 and 18 mont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d2dc866fd01376043f7da246e876b5
https://pubmed.ncbi.nlm.nih.gov/17825543
https://pubmed.ncbi.nlm.nih.gov/17825543