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Akademický článek

Two Distinct Mechanisms Mediate the Involvement of Bone Marrow Cells in Islet Remodeling: Neogenesis of Insulin-Producing Cells and Support of Islet Recovery

Autor: Svetlana Iskovich, Nitza Goldenberg-Cohen, Tamila Sadikov, Isaac Yaniv, Jerry Stein, Nadir Askenasy M.D., Ph.D.

Publikováno v: Cell Transplantation, Vol 24 (2015)

We have recently reported that small-sized bone marrow cells (BMCs) isolated by counterflow centrifugal elutriation and depleted of lineage markers (Fr25lin - ) have the capacity to differentiate and contribute to regeneration of injured islets. In t

Externí odkaz: https://doaj.org/article/1dd9fc6a7ea64645bf4a1e79bcb55347

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Akademický článek

Critical early events in hematopoietic cell seeding and engraftment.

Autor: Jerry Stein, Isaac Yaniv, Nadir Askenasy

Publikováno v: Folia Histochemica et Cytobiologica, Vol 43, Iss 4, Pp 191-195 (2005)

Durable hematopoietic stem cell engraftment requires efficient homing to and seeding in the recipient bone marrow. Dissection of cellular and molecular mechanisms by retrospective analysis of functional engraftment studies imposes severe limitations

Externí odkaz: https://doaj.org/article/629487b7838a427d9cb66f9aca20d8a4

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Akademický článek

Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice.

Autor: Ayelet Kaminitz, Esma S Yolcu, Enosh M Askenasy, Jerry Stein, Isaac Yaniv, Haval Shirwan, Nadir Askenasy

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21630 (2011)

BACKGROUND: Disturbed peripheral negative regulation might contribute to evolution of autoimmune insulitis in type 1 diabetes. This study evaluates the sensitivity of naïve/effector (Teff) and regulatory T cells (Treg) to activation-induced cell dea

Externí odkaz: https://doaj.org/article/550adadd10774031a12a319ee3e25e7d

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Akademický článek

Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice.

Autor: Ayelet Kaminitz, Enosh M Askenasy, Isaac Yaniv, Jerry Stein, Nadir Askenasy

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15684 (2010)

BACKGROUND: Regulatory T cells (Treg) play a significant role in immune homeostasis and self-tolerance. Excessive sensitivity of isolated Treg to apoptosis has been demonstrated in NOD mice and humans suffering of type 1 diabetes, suggesting a possib

Externí odkaz: https://doaj.org/article/02c36c75efed4218850fbfc63f54256d

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